Proteasi/Proteasoma
Gli inibitori delle proteasi e del proteasoma sono composti che bloccano l'attività delle proteasi e del proteasoma, che sono coinvolti nella degradazione e nel turnover delle proteine. Questi inibitori sono fondamentali per studiare la regolazione dell'omeostasi proteica, il controllo del ciclo cellulare e l'apoptosi. Gli inibitori delle proteasi e del proteasoma vengono anche utilizzati nel trattamento di malattie come il cancro, dove la degradazione anomala delle proteine svolge un ruolo nella progressione della malattia. Inibendo le proteasi o il proteasoma, questi composti possono indurre la morte cellulare nelle cellule tumorali e sono strumenti critici sia per la ricerca di base che per lo sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle proteasi e del proteasoma di alta qualità per supportare la tua ricerca in biochimica, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Proteasi/Proteasoma"
- Acetil-CoA carbossilasi(36 prodotti)
- Cisteina proteasi(110 prodotti)
- DPP-4(20 prodotti)
- Glutaminasi(45 prodotti)
- Proteasi HIV(506 prodotti)
- PAI-1(26 prodotti)
- Inibitori della proteasi(50 prodotti)
- Ricettore attivato dalla proteasi(54 prodotti)
- Proteasoma(95 prodotti)
- Proteasi serina(55 prodotti)
- p97(15 prodotti)
Mostrare 3 più sottocategorie
Trovati 1095 prodotti di "Proteasi/Proteasoma"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
DCLK1-IN-2
CAS:DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cellFormula:C26H32N8O3SColore e forma:SolidPeso molecolare:536.65AZD-7295
CAS:AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.Formula:C32H35F3N4O5SColore e forma:SolidPeso molecolare:644.7ND-378
CAS:ND-378 is a potent and selective inhibitor of MMP-2 with no inhibition on MMP-9 and MMP-14.Formula:C18H19NO4S2Purezza:98%Colore e forma:SolidPeso molecolare:377.48ONO 4817
CAS:ONO-4817 suppresses MMPs, limiting plaque progression and aortic hyperplasia in hyperlipidemic rabbits.Formula:C22H28N2O6Colore e forma:SolidPeso molecolare:416.47GS-6620
CAS:GS-6620 is a HCV nonstructural protein 5B (NS5B) inhibitor.Formula:C29H37N6O9PColore e forma:SolidPeso molecolare:644.61Ro 32-7315
CAS:Ro 32-7315 is a selective inhibitor of ADAM17.Formula:C22H35N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:453.6Berotralstat HCl
CAS:Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.Formula:C30H28Cl2F4N6OColore e forma:SolidPeso molecolare:635.4886Kallikrein-IN-2
CAS:Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formula:C28H25F3N4O4Colore e forma:SolidPeso molecolare:538.52Proteasome-IN-4
Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.Formula:C44H58N6O5Colore e forma:SolidPeso molecolare:750.97Cathepsin Inhibitor 2
CAS:Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).Formula:C19H21F6N3OPurezza:98%Colore e forma:SolidPeso molecolare:421.38PNU-103017
CAS:PNU-103017 is an inhibitor of HIV protease.Formula:C28H28N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:504.6Cathepsin K inhibitor 3
CAS:Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.Formula:C30H31FN4O4SColore e forma:SolidPeso molecolare:562.65MMP-9 Inhibitor I
CAS:MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).Formula:C27H33N3O5SColore e forma:SolidPeso molecolare:511.63Ravidasvir HCl
CAS:Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.Formula:C42H52Cl2N8O6Colore e forma:SolidPeso molecolare:835.828MMP-7-IN-2
CAS:MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.Formula:C28H40ClF3N6O9SPurezza:97.82%Colore e forma:SolidPeso molecolare:729.17Atecegatran metoxil
CAS:Atecegatran Metoxil (AZD0837), an oral thrombin inhibitor in development for stroke prevention in atrial fibrillation, is well-tolerated with favorable PK.Formula:C22H23ClF2N4O5Colore e forma:SolidPeso molecolare:496.89Cyclotheonellazole A
CAS:Cyclotheonellazole A inhibits elastase (IC50=0.034nM) & chymotrypsin (IC50=0.62nM), a natural macrocyclic peptide.Formula:C44H54N9NaO14S2Colore e forma:SolidPeso molecolare:1020.07Inogatran
CAS:Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.Formula:C21H38N6O4Purezza:98%Colore e forma:SolidPeso molecolare:438.56I-XW-053
CAS:I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-Formula:C22H16N2O2Purezza:99.05%Colore e forma:SolidPeso molecolare:340.37LY52
CAS:LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.Formula:C22H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:440.45KCC009
CAS:KCC009 is a potent and selective Transglutaminase 2 Inhibitor.Formula:C21H22BrN3O5Colore e forma:SolidPeso molecolare:476.32JTK-853
CAS:JTK-853: novel non-nucleoside HCV polymerase inhibitor with strong antiviral activity (EC50: 0.38 μM genotype 1a, 0.035 μM 1b).Formula:C28H23F7N6O4S2Purezza:98%Colore e forma:SolidPeso molecolare:704.64PTC725
CAS:PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.Formula:C23H18F4N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:518.49MK-3281
CAS:MK-3281: Oral, potent HCV NS5B inhibitor with promising properties and efficacy in replication trials, suitable for clinical use.Formula:C29H37N3O3Colore e forma:SolidPeso molecolare:475.62Cipemastat
CAS:Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).Formula:C22H36N4O5Purezza:98%Colore e forma:SolidPeso molecolare:436.55Petesicatib
CAS:Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.Formula:C25H23F6N5O4SPurezza:99.76%Colore e forma:SolidPeso molecolare:603.54Ref: TM-T16474
1mg105,00€5mg250,00€10mg393,00€25mg777,00€50mg1.198,00€100mg1.549,00€200mg2.080,00€1mL*10mM (DMSO)331,00€MMP13-IN-3
CAS:MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.Formula:C24H22N4O5Purezza:99.76%Colore e forma:SolidPeso molecolare:446.46Ref: TM-T16124
1mg87,00€5mg216,00€10mg354,00€25mg620,00€50mg847,00€100mg1.169,00€1mL*10mM (DMSO)240,00€FK706
CAS:FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.Formula:C26H33F3N4NaO7Colore e forma:SolidPeso molecolare:593.556XL-784
CAS:XL-784 is a selective MMP inhibitor with low IC50s for MMP-1,2,3,8,9,13, modulating extracellular matrix remodeling, tumor invasion, and metastasis in cancer.Formula:C42H42Cl2F4MgN6O16S2Purezza:98%Colore e forma:SolidPeso molecolare:1122.15Collagen proline hydroxylase inhibitor
CAS:<p>Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.</p>Formula:C18H18N4O4Purezza:98%Colore e forma:SolidPeso molecolare:354.36NK3201
CAS:NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters.Formula:C31H29N5O6Purezza:98%Colore e forma:SolidPeso molecolare:567.59Z-PDLDA-NHOH
CAS:Z-PDLDA-NHOH is a potent, specific vertebrate collagenase inhibitor [1].Formula:C22H32N4O6Colore e forma:SolidPeso molecolare:448.51GSK-2485852
CAS:GSK-2485852, a NS5B inhibitor, is used potentially for treatment of HCV infection.Formula:C27H25BF2N2O6SColore e forma:SolidPeso molecolare:554.37Reverse transcriptase-IN-1
CAS:Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7Formula:C25H17N7O2Purezza:99.61%Colore e forma:SolidPeso molecolare:447.45Ref: TM-T12715
1mg64,00€5mg131,00€10mg183,00€25mg311,00€50mg449,00€100mg615,00€200mg833,00€1mL*10mM (DMSO)143,00€XL-784 free base
CAS:XL-784 free base selectively inhibits MMPs with IC50: MMP-1 (1.9µM), MMP-2 (0.81nM), MMP-3 (120nM), MMP-8 (10.8nM), MMP-9 (18nM), MMP-13 (0.56nM).Formula:C21H22ClF2N3O8SPurezza:98%Colore e forma:SolidPeso molecolare:549.93MDL-101146, (R)-
CAS:MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.Formula:C29H37F5N4O6Purezza:98%Colore e forma:SolidPeso molecolare:632.62DS-1040 Tosylate
CAS:DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFI) inhibitor and a fibrinolysis enhancer, used for researching thromboembolic diseases.Formula:C23H35N3O5SColore e forma:SolidPeso molecolare:465.61SSR 69071
CAS:SSR69071: selective neutrophil elastase inhibitor, stronger for humans (Ki=0.0168 nM), may treat COPD, asthma, and reduce heart injury.Formula:C27H32N4O7SColore e forma:SolidPeso molecolare:556.63Phe-Pro-Ala-pNA
CAS:Phe-Pro-Ala-pNA is a chromogenic substrate utilized for assessing tripeptidyl peptidase activity.Formula:C23H27N5O5Colore e forma:SolidPeso molecolare:453.49MDL 27324
CAS:MDL 27324 is an inhibitor of human neutrophil elastase.Formula:C29H38F3N5O6SPurezza:98%Colore e forma:SolidPeso molecolare:641.7BAY-678
CAS:BAY-678: Oral selective human neutrophil elastase inhibitor; IC50: 20 nM; SGC-approved chemical probe.Formula:C20H15F3N4O2Purezza:99.36%Colore e forma:SolidPeso molecolare:400.35Ref: TM-T10473
5mg39,00€10mg64,00€25mg126,00€50mg183,00€100mg279,00€200mg395,00€1mL*10mM (DMSO)44,00€Z-FG-NHO-BzOME
CAS:Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,Formula:C27H27N3O7Colore e forma:SolidPeso molecolare:505.52KB-R7785
CAS:KB-R7785 is a novel ADAM12/MMP inhibitor improving heart function and insulin sensitivity by blocking HB-EGF and TNF-alpha.Formula:C18H27N3O4Colore e forma:SolidPeso molecolare:349.42MDL 101146
CAS:MDL 101146 is an orally active neutrophil elastase inhibitor.Formula:C29H37F5N4O6Purezza:98%Colore e forma:SolidPeso molecolare:632.62O-Benzoylhydroxylamine
CAS:O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].Formula:C7H7NO2Colore e forma:SolidPeso molecolare:137.14Neurodegenerative Disorder-Targeting Compound 1
CAS:Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].Formula:C28H28N4O4Purezza:98%Colore e forma:SolidPeso molecolare:484.55MMP-7-IN-3
CAS:MMP-7-IN-3 (compound 15) is a potent and selective MMP-7 inhibitor, inhibiting renal fibrosis in a unilateral ureteral obstruction mouse model.Formula:C34H43ClF3N7O9SPurezza:99.915%Colore e forma:SolidPeso molecolare:818.26MMP-145
CAS:MMP-145 is used as a protease inhibitor.Formula:C20H20N2O7SPurezza:98%Colore e forma:SolidPeso molecolare:432.45BMS-189664
CAS:BMS-189664 is an inhibitor of thrombin.Formula:C22H34N6O4SPurezza:98%Colore e forma:SolidPeso molecolare:478.61MMP-3 Inhibitor VIII
CAS:Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.Formula:C20H26N2O5SColore e forma:SolidPeso molecolare:406.5
