Proteasi/Proteasoma
Gli inibitori delle proteasi e del proteasoma sono composti che bloccano l'attività delle proteasi e del proteasoma, che sono coinvolti nella degradazione e nel turnover delle proteine. Questi inibitori sono fondamentali per studiare la regolazione dell'omeostasi proteica, il controllo del ciclo cellulare e l'apoptosi. Gli inibitori delle proteasi e del proteasoma vengono anche utilizzati nel trattamento di malattie come il cancro, dove la degradazione anomala delle proteine svolge un ruolo nella progressione della malattia. Inibendo le proteasi o il proteasoma, questi composti possono indurre la morte cellulare nelle cellule tumorali e sono strumenti critici sia per la ricerca di base che per lo sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle proteasi e del proteasoma di alta qualità per supportare la tua ricerca in biochimica, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Proteasi/Proteasoma"
- Acetil-CoA carbossilasi(36 prodotti)
- Cisteina proteasi(110 prodotti)
- DPP-4(24 prodotti)
- Glutaminasi(44 prodotti)
- Proteasi HIV(496 prodotti)
- PAI-1(26 prodotti)
- Inibitori della proteasi(50 prodotti)
- Ricettore attivato dalla proteasi(54 prodotti)
- Proteasoma(87 prodotti)
- Proteasi serina(51 prodotti)
- p97(15 prodotti)
Mostrare 3 più sottocategorie
Trovati 990 prodotti di "Proteasi/Proteasoma"
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Adamtsostatin 18
CAS:Adamtsostatin 18, an anti-angiogenic peptide derived from proteins with type I thrombospondin motifs, suppresses cell migration and proliferation [1].Formula:C89H141N29O29S2Colore e forma:SolidPeso molecolare:2145.38RXP470
CAS:RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).Formula:C35H35BrClN4O10PColore e forma:SolidPeso molecolare:818FXIIa-IN-1
CAS:XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 97.8 nM, utilized in the study of thrombosis [1].Formula:C21H16N2O6Colore e forma:SoildPeso molecolare:392.36Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effectFormula:C47H64N14O10Colore e forma:SolidPeso molecolare:985.1Rivulariapeptolides 1155
Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).Formula:C59H81N9O15Colore e forma:SolidPeso molecolare:1156.33Nitidanin
Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.Formula:C21H24O8Colore e forma:SolidPeso molecolare:404.415Pseudostellarin G
CAS:Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.Formula:C42H56N8O9Colore e forma:SolidPeso molecolare:816.94RJS308
RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)Formula:C63H75N13O11SColore e forma:SolidPeso molecolare:1222.42Lonodelestat TFA
Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.Formula:C73H112F3N15O21Colore e forma:SolidPeso molecolare:1592.75Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Colore e forma:Odour SolidElastase (high purity)
Elastase (high purity) is a serine protease that hydrolyzes proteins and peptides.Colore e forma:Odour SolidKnob A peptide GPRPFPAC
CAS:Knob A peptide GPRPFPAC is a fibrin knob peptide. The PEGylated form of Knob A peptide GPRPFPAC exhibits enhanced anticoagulant activity.Formula:C38H57N11O9SColore e forma:SolidPeso molecolare:843.99Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Colore e forma:Odour SolidL 659286
CAS:L 659286 is one kind of cephalosporin derivative.Formula:C17H21N5O7S2Colore e forma:SolidPeso molecolare:471.51JC-10
CAS:JC-10 is a potent inhibitor of metalloproteinases and is often used as a probe.Formula:C25H29Cl2IN4Purezza:95%Colore e forma:SolidPeso molecolare:583.34GSK2818713
CAS:GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.Formula:C46H56N8O8Colore e forma:SolidPeso molecolare:849.002Ellipyrone A
Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).Formula:C25H34O8Colore e forma:SolidPeso molecolare:462.53Leptosin D
CAS:Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)Formula:C25H24N4O3S2Colore e forma:SolidPeso molecolare:492.61Ecallantide TFA
Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention ofColore e forma:Odour SolidSofosbuvir impurity H
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir.Formula:C29H33FN3O10PPurezza:98%Colore e forma:SolidPeso molecolare:633.56Plasma kallikrein-IN-1
CAS:Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.Formula:C23H25F2N7OColore e forma:SolidPeso molecolare:453.498Histatin 5 TFA
Histatin 5 TFA effectively inhibits host matrix metalloproteinases (MMP-2) and (MMP-9), demonstrating inhibition concentrations (IC 50s) of 0.57 μM and 0.25 μMFormula:C135H196N51F3O35Colore e forma:SolidPeso molecolare:3150.31ZG36
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrialColore e forma:Odour SolidAnticancer agent 114
Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.Formula:C28H33BF6N2O7Colore e forma:SolidPeso molecolare:634.37Peptide 74
CAS:Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.Formula:C62H107N23O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1558.79CRA-2059 hydrochloride
CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].Colore e forma:SolidSulodexide
CAS:Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.Colore e forma:SolidNostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).Formula:C25H33N5O6Colore e forma:SolidPeso molecolare:499.56Sofosbuvir impurity A
CAS:Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.Formula:C22H29FN3O9PPurezza:98%Colore e forma:SolidPeso molecolare:529.45MeOSuc-AAPF-CMK
CAS:MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH2Cl) is a potent inhibitor of the enzyme proteinase K [1].Formula:C26H35ClN4O7Colore e forma:SolidPeso molecolare:551.03α 1 Antichymotrypsin, Human Plasma
CAS:Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.Colore e forma:SolidAc-Phe-Gly-pNA
CAS:Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .Formula:C19H20N4O5Colore e forma:SolidPeso molecolare:384.39DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Colore e forma:Odour SolidStevia Powder
Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.Colore e forma:Odour SolidHistatin 5
CAS:Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.Formula:C133H195N51O33Purezza:98%Colore e forma:SolidPeso molecolare:3036.29N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formula:C35H37F3N6O8Purezza:99.88%Colore e forma:SolidPeso molecolare:726.7PSI-7409
CAS:PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).
Formula:C10H16FN2O14P3Purezza:98%Colore e forma:SolidPeso molecolare:500.16PPACK II
CAS:PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor [1] .Formula:C25H33ClN6O3Colore e forma:SolidPeso molecolare:501.02Platelet aggregation-IN-1
Platelet aggregation-IN-1 (Compound 10e) acts as an inhibitor of platelet aggregation and can achieve complete (100%) inhibition of thrombin-induced platelet aggregation at a concentration of 50 μM.Formula:C18H13N3O4Peso molecolare:335.09061MMP Inhibitor 4
MMP Inhibitor4 (compound 4 B) is an effective MMP inhibitor with anti-proliferative properties. It induces cell cycle arrest at the subG1 phase and reduces the mRNA expression of MMP2, MMP9, and VEGFA.Formula:C16H18BrClN2O5Colore e forma:SolidPeso molecolare:433.68MK-6169
CAS:MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.Formula:C54H62FN9O8SPurezza:98%Colore e forma:SolidPeso molecolare:1016.2SL44
SL44 is an agonist of human caseinolytic protease P (HsClpP) with an EC50 of 1.30 μM. It inhibits LM3 proliferation with an IC50 of 3.1 μM and induces apoptosis in liver cancer cells by degrading respiratory chain complex subunits. In mouse models, SL44 demonstrates antitumor activity without significant toxicity (LD50=400 mg/kg) and exhibits favorable pharmacokinetic properties in rat models.Formula:C22H20ClFN4OPeso molecolare:410.13097Tyrosinase/elastase-IN-1
Tyrosinase/elastase-IN-1, a triterpenoid extracted from the leaves of Rubus fraxinifolius, exhibits inhibitory activities against both tyrosinase and elastaseFormula:C33H52O5Colore e forma:SolidPeso molecolare:528.76N-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formula:C33H36N6O6Purezza:98%Colore e forma:White To Off-White PowderPeso molecolare:612.68Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formula:C4H10AsNO4Peso molecolare:210.98258Cathepsin Inhibitor 4
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.
Formula:C24H35N3O5Peso molecolare:445.25767Phaeosphaone D
CAS:Phaeosphaone D, a thiodiketopiperazine from Phaeosphaeria fuckelii fungus, inhibits mushroom tyrosinase (IC50 = 33.2 μM).Formula:C20H27N3O3S2Colore e forma:SolidPeso molecolare:421.58FiVe1
CAS:FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.
Formula:C18H16Cl2N4Purezza:99.67%Colore e forma:SolidPeso molecolare:359.25Elastatinal
CAS:Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.Formula:C21H36N8O7Colore e forma:Yellowish SolidPeso molecolare:512.56Fibrinogen-Binding Peptide
CAS:Fibrinogen-binding peptide mimics vitronectin site and activates platelets; thrombin turns it to fibrin.Formula:C25H39N7O8Purezza:98%Colore e forma:SolidPeso molecolare:565.62
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