Proteasoma
Gli inibitori del proteasoma sono composti che inibiscono il proteasoma, un grande complesso proteico responsabile della degradazione delle proteine non desiderate o danneggiate all'interno della cellula. L'inibizione del proteasoma porta all'accumulo di proteine, che può indurre l'arresto del ciclo cellulare e l'apoptosi, in particolare nelle cellule che si dividono rapidamente, come le cellule tumorali. Gli inibitori del proteasoma sono fondamentali nella ricerca e nella terapia del cancro, specialmente nel trattamento del mieloma multiplo e di altre neoplasie ematologiche. Presso CymitQuimica, offriamo inibitori del proteasoma per supportare la tua ricerca in oncologia, biologia cellulare e sviluppo di farmaci.
Trovati 95 prodotti di "Proteasoma"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Trelagliptin
CAS:Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.Formula:C18H20FN5O2Purezza:98.88%Colore e forma:SolidPeso molecolare:357.38Gabexate mesylate
CAS:Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Formula:C17H27N3O7SPurezza:99.2% - 99.64%Colore e forma:White CrystalPeso molecolare:417.48Saxagliptin hydrate
CAS:Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).Formula:C18H25N3O2·H2OPurezza:99.52%Colore e forma:SolidPeso molecolare:333.43Arimoclomol maleate
CAS:<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Formula:C18H24ClN3O7Purezza:99.44% - 99.98%Colore e forma:SolidPeso molecolare:429.85UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormula:C15H12F4N4O2Purezza:98.12%Colore e forma:SolidPeso molecolare:356.27Sitagliptin
CAS:Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.Formula:C16H15F6N5OPurezza:99.33% - 99.83%Colore e forma:Yellow GreasePeso molecolare:407.31RAMB4
CAS:RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Formula:C19H13Cl4NOPurezza:98.89% - 99.38%Colore e forma:SolidPeso molecolare:413.12Gly-Pro-pNA hydrochloride
CAS:<p>Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase</p>Formula:C13H17ClN4O4Purezza:99.84%Colore e forma:SolidPeso molecolare:328.75ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Formula:C17H24BF3N2O4Purezza:97.06%Colore e forma:SolidPeso molecolare:388.19Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formula:C34H63N5O9Purezza:96.74% - 99.94%Colore e forma:SolidPeso molecolare:685.89DBPR108
CAS:<p>DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.</p>Formula:C16H25FN4O2Purezza:99.68%Colore e forma:SolidPeso molecolare:324.39RA190
CAS:<p>RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.</p>Formula:C28H23Cl5N2O2Purezza:97.7%Colore e forma:SolidPeso molecolare:596.76Phepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Formula:C38H60N6O6Colore e forma:SolidPeso molecolare:696.92Procizumab
Procizumab is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). It shows potential for investigating sepsis. For the isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidDazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purezza:99.11%Colore e forma:SolidPeso molecolare:395.38Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formula:C48H56N6O10SColore e forma:SolidPeso molecolare:909.06Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formula:C142H230N36O44SPeso molecolare:3175.65874VAMP
<p>VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.</p>Formula:C18H32N4O5SColore e forma:SolidPeso molecolare:416.535Acetyl-Calpastatin(184-210)(human)
CAS:Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Formula:C142H230N36O44SPurezza:98%Colore e forma:SolidPeso molecolare:3177.65Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidPhepropeptin B
CAS:Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.Formula:C40H56N6O6Colore e forma:SolidPeso molecolare:716.91LXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Formula:C27H22FN7O6Purezza:99.89%Colore e forma:SoildPeso molecolare:559.51PROTAC 20S proteasome subunit β5 degrader 2
<p>PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.</p>Colore e forma:Odour Solidβ5i-IN-1
β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM.Purezza:98%Colore e forma:Odour SolidPhepropeptin D
CAS:Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.Formula:C41H58N6O6Colore e forma:SolidPeso molecolare:730.94Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Colore e forma:Odour SolidDPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Formula:C33H27N7O3Colore e forma:SolidPeso molecolare:569.613DPP8/9-IN-1
<p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>Colore e forma:Odour SolidPhepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Formula:C37H58N6O6Colore e forma:SolidPeso molecolare:682.89Cerpegin
CAS:Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.Formula:C10H11NO3Colore e forma:SolidPeso molecolare:193.2Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Formula:C144H231F3N36O46SColore e forma:SolidPeso molecolare:3291.65LMP7/LMP2-IN-1
CAS:LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Formula:C16H27BN4O3Colore e forma:SoildPeso molecolare:334.22H-Pro-Lys-OH TFA
H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.Formula:C13H22F3N3O5Colore e forma:SolidPeso molecolare:357.335-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Formula:C9H8N2OPurezza:99.69%Colore e forma:SolidPeso molecolare:160.17Alogliptin (13CD3)
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Formula:C18H21N5O2Purezza:98%Colore e forma:SolidPeso molecolare:343.4Teneligliptin D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Formula:C22H30N6OSPurezza:98%Colore e forma:SolidPeso molecolare:434.63VR23
CAS:<p>VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.</p>Formula:C19H16ClN5O6SPurezza:98.99% - 99.22%Colore e forma:SolidPeso molecolare:477.8818α-Glycyrrhetinic acid
CAS:18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Formula:C30H46O4Purezza:98.54% - 99.68%Colore e forma:SolidPeso molecolare:470.68TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Formula:C39H37N3O3Purezza:98.2% - 98.75%Colore e forma:SolidPeso molecolare:595.73Ixazomib citrate
CAS:Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).Formula:C20H23BCl2N2O9Purezza:98.37% - >99.99%Colore e forma:SolidPeso molecolare:517.12MG-132
CAS:<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Formula:C26H41N3O5Purezza:95% - 99.99%Colore e forma:White To Off-White PowderPeso molecolare:475.62Alloxan monohydrate
CAS:<p>Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.</p>Formula:C4H4N2O5Purezza:99.01% - 99.42%Colore e forma:Off-White To Beige-Yellowish Crystalline PowderPeso molecolare:160.09ARV-471
CAS:<p>ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.</p>Formula:C45H49N5O4Purezza:97.15% - >99.99%Colore e forma:SolidPeso molecolare:723.9Omarigliptin
CAS:Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. Cost-effective and quality-assured.Formula:C17H20F2N4O3SPurezza:99.68% - 99.77%Colore e forma:SolidPeso molecolare:398.43Calpeptin
CAS:Calpeptin is a potent, cell-permeable calpain inhibitor.Formula:C20H30N2O4Purezza:97.06% - 98.33%Colore e forma:White To Off-White PowderPeso molecolare:362.46Talabostat mesylate
CAS:<p>Talabostat mesylate (PT100): Oral DPP4 inhibitor, IC50 0.18 nM, targets tumor-linked proteins, boosts hematopoiesis.</p>Formula:C10H23BN2O6SPurezza:98% - 99.91%Colore e forma:SolidPeso molecolare:310.18PI-1840
CAS:<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Formula:C22H26N4O3Purezza:98.82%Colore e forma:SolidPeso molecolare:394.474'-Hydroxychalcone
CAS:<p>4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity</p>Formula:C15H12O2Purezza:99.86% - 99.87%Colore e forma:Yellow-Cream PowderPeso molecolare:224.25ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Formula:C31H40N4O7Purezza:98.24% - 99.31%Colore e forma:SolidPeso molecolare:580.67Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purezza:97.79% - >99.99%Colore e forma:Yellow SolidPeso molecolare:384.24Epoxomicin
CAS:<p>Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.</p>Formula:C28H50N4O7Purezza:98.65% - 98.86%Colore e forma:White To Off-White SolidPeso molecolare:554.72Carfilzomib
CAS:Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.Formula:C40H57N5O7Purezza:99.6% - 99.84%Colore e forma:SolidPeso molecolare:719.91MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formula:C22H26N2O4Purezza:95.06%Colore e forma:SolidPeso molecolare:382.45ISOGINKGETIN
CAS:<p>ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.</p>Formula:C32H22O10Purezza:98% - 99.72%Colore e forma:SolidPeso molecolare:566.51Oprozomib
CAS:Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.Formula:C25H32N4O7SPurezza:98% - 99.87%Colore e forma:SolidPeso molecolare:532.61UAMC00039 dihydrochloride
CAS:UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.Formula:C16H26Cl3N3OPurezza:>99.99%Colore e forma:SolidPeso molecolare:382.76MUN57694
CAS:MUN57694 is an inhibitor of 26S proteasome.Formula:C23H25N3O4Purezza:99%Colore e forma:SolidPeso molecolare:407.46Saxagliptin
CAS:<p>Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.</p>Formula:C18H25N3O2Purezza:99.17% - 99.95%Colore e forma:SolidPeso molecolare:315.41Tomatine
CAS:<p>Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.</p>Formula:C50H83NO21Purezza:98.42% - 99.94%Colore e forma:White To Light YellowPeso molecolare:1034.19MG-101
CAS:MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.Formula:C20H37N3O4Purezza:98% - ≥98%Colore e forma:SolidPeso molecolare:383.53Bortezomib-pinanediol
CAS:Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.Formula:C29H39BN4O4Purezza:97.5%Colore e forma:Yellow SolidPeso molecolare:518.46DD1
CAS:<p>DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.</p>Formula:C16H14N2O3Purezza:99.57%Colore e forma:SolidPeso molecolare:282.29Tripterin
CAS:Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.Formula:C29H38O4Purezza:98.56% - 99.8%Colore e forma:Red Crystalline PowderPeso molecolare:450.61Cilastatin
CAS:Cilastatin (MK0791): protects imipenem from renal breakdown; inhibits leukotriene D4 metabolism.Formula:C16H26N2O5SPurezza:97.76% - 99.71%Colore e forma:SolidPeso molecolare:358.45Proteasome inhibitor IX
CAS:Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).Formula:C20H21B2NO5Purezza:99.77%Colore e forma:SolidPeso molecolare:377.01Brensocatib
CAS:<p>Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).</p>Formula:C23H24N4O4Purezza:97.55%Colore e forma:SolidPeso molecolare:420.46Anagliptin
CAS:Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.Formula:C19H25N7O2Purezza:97.59% - 99.98%Colore e forma:SolidPeso molecolare:383.45Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Formula:C14H19BCl2N2O4Purezza:98% - 98.92%Colore e forma:SolidPeso molecolare:361.03Trelagliptin succinate
CAS:Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (Formula:C22H26FN5O6Purezza:99.27% - 99.92%Colore e forma:SolidPeso molecolare:475.47(R)-MG-132
CAS:(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.Formula:C26H41N3O5Purezza:99.90%Colore e forma:SolidPeso molecolare:475.62Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Formula:C21H28BN3O5Purezza:95.52% - 99.46%Colore e forma:SolidPeso molecolare:413.28Sitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.Formula:C16H15F6N5O·H3PO4·H2OPurezza:99.85% - 99.98%Colore e forma:White Or Almost White Crystalline PowderPeso molecolare:523.33KZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Formula:C21H23N3O6Colore e forma:SolidPeso molecolare:413.42Proteasome-IN-1
CAS:<p>Proteasome-IN-1 is an inhibitor of proteasome.</p>Formula:C42H35N5O3Purezza:98%Colore e forma:SolidPeso molecolare:657.76Gemigliptin Tartrate(911637-19-9 free base)
CAS:<p>Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).</p>Formula:C22H25F8N5O8Purezza:>99.99%Colore e forma:SolidPeso molecolare:639.45Diprotin B
CAS:Diprotin B is a dipeptidyl peptidase IV inhibitor.Formula:C16H29N3O4Purezza:98%Colore e forma:White Lyophilized PowderPeso molecolare:327.42Z-LLF-CHO
CAS:<p>Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.</p>Formula:C29H39N3O5Purezza:98%Colore e forma:SolidPeso molecolare:509.64BC-23
CAS:BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.Formula:C21H14ClN3O4SPurezza:98%Colore e forma:SolidPeso molecolare:439.87Gemigliptin
CAS:Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)Formula:C18H19F8N5O2Purezza:99.72%Colore e forma:SolidPeso molecolare:489.3620S Proteasome activator 1
CAS:20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.Formula:C27H19ClF2N2OSPurezza:99.82%Colore e forma:SolidPeso molecolare:492.97Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Formula:C14H20ClN3O3Purezza:99.15%Colore e forma:SolidPeso molecolare:313.78LU-002i
CAS:<p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>Formula:C35H52N4O7Purezza:98%Colore e forma:SolidPeso molecolare:640.81Proteasome-IN-5
CAS:<p>Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].</p>Formula:C20H30BN5O7Purezza:98%Colore e forma:SolidPeso molecolare:463.29Proteasome β2c/i-IN-1
CAS:<p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>Formula:C32H48N4O7Purezza:98%Colore e forma:SolidPeso molecolare:600.75BI-1942
CAS:<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Formula:C24H26N4O4Colore e forma:SolidPeso molecolare:434.488ZINC09518833
CAS:ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).Formula:C24H25N3O5Colore e forma:SolidPeso molecolare:435.47RBx-0597
CAS:<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Formula:C19H20F2N4O2Colore e forma:SolidPeso molecolare:374.384(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Formula:C22H30N6OSColore e forma:SolidPeso molecolare:426.578DPP-4-IN-15
CAS:DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Formula:C17H14F3N3O2SColore e forma:SolidPeso molecolare:381.372Marizomib
CAS:Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Formula:C15H20ClNO4Purezza:98.03% - 99.41%Colore e forma:SolidPeso molecolare:313.78Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formula:C22H27F8N5O9Colore e forma:SolidPeso molecolare:657.47Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Formula:C24H23N3O3Colore e forma:SolidPeso molecolare:401.46PB01
CAS:<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Formula:C18H21N5O3Colore e forma:SolidPeso molecolare:355.391TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Formula:C19H14BrClN4O2SColore e forma:SolidPeso molecolare:477.762Davelizomib
CAS:<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formula:C21H26BF2N3O7Purezza:98%Colore e forma:SolidPeso molecolare:481.25
