Cellule staminali e Derivati
Gli inibitori delle cellule staminali sono composti che bersagliano specificamente le vie di segnalazione e le proteine coinvolte nel mantenimento, nella differenziazione e nella proliferazione delle cellule staminali. Questi inibitori sono cruciali per comprendere la biologia delle cellule staminali e per sviluppare strategie per manipolare le cellule staminali a fini terapeutici, come la medicina rigenerativa e il trattamento del cancro. Controllando il destino delle cellule staminali, questi inibitori possono aiutare a guidare la differenziazione delle cellule staminali in tipi cellulari specifici o a prevenire una crescita cellulare indesiderata. Presso CymitQuimica, offriamo una selezione di inibitori delle cellule staminali di alta qualità per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e medicina rigenerativa.
Sottocategorie di "Cellule staminali e Derivati"
- Gamma-secretasi(59 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Via di segnalazione Hippo(6 prodotti)
- JAK(245 prodotti)
- Proteina Porcupine(9 prodotti)
- ROCK(70 prodotti)
- STAT(98 prodotti)
- Cellule staminali(486 prodotti)
- TGF-beta/Smad(58 prodotti)
- Wnt/beta-catenina(66 prodotti)
Mostrare 2 più sottocategorie
Trovati 695 prodotti di "Cellule staminali e Derivati"
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Afuresertib hydrochloride
CAS:<p>Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)</p>Formula:C18H18Cl3FN4OSPurezza:99.96%Colore e forma:SolidPeso molecolare:463.8Ruxolitinib phosphate
CAS:<p>Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.</p>Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36WAY 316606
CAS:<p>WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.</p>Formula:C18H19F3N2O4S2Purezza:99.65%Colore e forma:SolidPeso molecolare:448.48KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formula:C17H11Cl2N3O2Purezza:98.06%Colore e forma:SolidPeso molecolare:360.19GLPG0634 analog
CAS:<p>GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.</p>Formula:C23H18N6O2Purezza:99.52% - >99.99%Colore e forma:SolidPeso molecolare:410.43AR-A014418
CAS:<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Formula:C12H12N4O4SPurezza:>99.99% - ≥95%Colore e forma:SolidPeso molecolare:308.31MYF-01-37
CAS:<p>MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.</p>Formula:C15H17F3N2OPurezza:99.46% - 99.5%Colore e forma:SolidPeso molecolare:298.3BP-1-102
CAS:<p>BP-1-102 is an orally active, effective and specific STAT3 inhibitor.</p>Formula:C29H27F5N2O6SPurezza:99.25% - 99.44%Colore e forma:SolidPeso molecolare:626.59Cardiogenol C hydrochloride
CAS:<p>Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).</p>Formula:C13H17ClN4O2Purezza:99.89% - 99.94%Colore e forma:SolidPeso molecolare:296.75Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formula:C16H11N3O2Purezza:98.34%Colore e forma:SolidPeso molecolare:277.28IHR-1
CAS:<p>IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.</p>Formula:C20H12Cl4N2O2Purezza:97.02%Colore e forma:SolidPeso molecolare:454.13iCRT 14
CAS:<p>iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).</p>Formula:C21H17N3O2SPurezza:99.8% - 99.97%Colore e forma:SolidPeso molecolare:375.44LGK974
CAS:<p>LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.</p>Formula:C23H20N6OPurezza:98.8% - >99.99%Colore e forma:SolidPeso molecolare:396.44(E/Z)-GO289
CAS:<p>(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.</p>Formula:C17H15BrN4O2SPurezza:98.1%Colore e forma:SolidPeso molecolare:419.3CMD178 TFA
<p>CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.</p>Formula:C48H60F3N9O9Purezza:>99.99%Colore e forma:SolidPeso molecolare:964.05URMC-099
CAS:<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Formula:C27H27N5Purezza:99.32% - 99.98%Colore e forma:SolidPeso molecolare:421.54Lats-IN-1
CAS:<p>Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.</p>Formula:C18H14N4OSPurezza:97.54% - 99.79%Colore e forma:SolidPeso molecolare:334.39WHI-P154
CAS:<p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>Formula:C16H14BrN3O3Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:376.2(Z)-LFM-A13
CAS:<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Formula:C11H8Br2N2O2Purezza:99.88%Colore e forma:SolidPeso molecolare:360NVP-BSK805 trihydrochloride
CAS:<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Formula:C27H31Cl3F2N6OColore e forma:SolidPeso molecolare:599.93BMS-911543
CAS:<p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>Formula:C23H28N8OPurezza:97.69% - 99.98%Colore e forma:SolidPeso molecolare:432.52VP3.15 dihydrobromide
CAS:<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Formula:C20H24Br2N4OSPurezza:99.67% - ≥95%Colore e forma:SolidPeso molecolare:528.3PF-670462
CAS:<p>PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.</p>Formula:C19H22Cl2FN5Purezza:99.42% - 99.72%Colore e forma:SolidPeso molecolare:410.323,5-Bis(4-nitrophenoxy)benzoic acid
CAS:<p>3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It decreases the released levels of Aβ42 and notch-1 Aβ-like peptide 25.</p>Formula:C19H12N2O8Purezza:99.14%Colore e forma:SolidPeso molecolare:396.31SAR407899 hydrochloride
CAS:<p>SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and</p>Formula:C14H17ClN2O2Purezza:99.15%Colore e forma:SolidPeso molecolare:280.75XMU-MP-1
CAS:<p>XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!</p>Formula:C17H16N6O3S2Purezza:99.68% - 99.79%Colore e forma:SolidPeso molecolare:416.48Cardiogenol C
CAS:<p>Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.</p>Formula:C13H16N4O2Purezza:98.46%Colore e forma:SolidPeso molecolare:260.29Momelotinib
CAS:<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Formula:C23H22N6O2Purezza:97.47% - 99.56%Colore e forma:SolidPeso molecolare:414.46Teplinovivint
CAS:<p>Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy</p>Formula:C25H26N6O2Purezza:97.21%Colore e forma:SolidPeso molecolare:442.51AZD1080
CAS:<p>AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.</p>Formula:C19H18N4O2Purezza:97.72% - 99.75%Colore e forma:SolidPeso molecolare:334.37IMR-1A
CAS:<p>IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formula:C13H11NO5S2Purezza:97.1% - 99.76%Colore e forma:SolidPeso molecolare:325.36LY3200882
CAS:<p>LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).</p>Formula:C24H29N5O3Purezza:99.46% - 99.63%Colore e forma:SolidPeso molecolare:435.52Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Formula:C30H42O7Purezza:96.69% - 99.8%Colore e forma:SolidPeso molecolare:514.65β-catenin-IN-2
CAS:<p>β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.</p>Formula:C15H14FN3Purezza:99.93%Colore e forma:SolidPeso molecolare:255.29I3MT-3
CAS:<p>I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.</p>Formula:C17H14N2O2SPurezza:99.76%Colore e forma:SolidPeso molecolare:310.37ML116
CAS:<p>ML116 is a potent and selective STAT3 inhibitor.</p>Formula:C18H19N3SPurezza:99.49%Colore e forma:SolidPeso molecolare:309.43TTP 22
CAS:<p>TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.</p>Formula:C16H14N2O2S2Purezza:97.08% - 97.78%Colore e forma:SolidPeso molecolare:330.42Momelotinib HCl
CAS:<p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>Formula:C23H24Cl2N6O2Colore e forma:SolidPeso molecolare:487.38SH-4-54
CAS:<p>SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.</p>Formula:C29H27F5N2O5SPurezza:98% - 99.12%Colore e forma:SolidPeso molecolare:610.59TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formula:C10H10N2O2SPurezza:97.13% - 99.61%Colore e forma:White SolidPeso molecolare:222.26JI130
CAS:<p>JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.</p>Formula:C23H24N2O3Purezza:99.61%Colore e forma:SolidPeso molecolare:376.45GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formula:C16H11N5O2SPurezza:98.86%Colore e forma:SolidPeso molecolare:337.36Deucravacitinib
CAS:<p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>Formula:C20H19D3N8O3Purezza:98.52% - >99.99%Colore e forma:SolidPeso molecolare:425.46SKL2001
CAS:<p>SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.</p>Formula:C14H14N4O3Purezza:97.46% - 99.5%Colore e forma:SolidPeso molecolare:286.29ZINC00881524
CAS:<p>ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.</p>Formula:C21H20N2O3SPurezza:99.48%Colore e forma:SolidPeso molecolare:380.46Tegatrabetan
CAS:<p>Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.</p>Formula:C28H36N4O6S2Purezza:98.01% - 99.18%Colore e forma:SolidPeso molecolare:588.74Baricitinib
CAS:<p>Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.</p>Formula:C16H17N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:371.42AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Formula:C20H20ClN5O2Purezza:98.27% - 98.7%Colore e forma:SolidPeso molecolare:397.86Porcn-IN-1
CAS:<p>Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).</p>Formula:C25H19FN4OPurezza:99.15%Colore e forma:SolidPeso molecolare:410.44Thiazovivin
CAS:<p>Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.</p>Formula:C15H13N5OSPurezza:98.00%Colore e forma:SolidPeso molecolare:311.36Hydroxyfasudil
CAS:<p>Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).</p>Formula:C14H17N3O3SPurezza:98.13%Colore e forma:SolidPeso molecolare:307.37GDC-0214
CAS:<p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>Formula:C28H28ClF2N9O3Purezza:99.75%Colore e forma:SolidPeso molecolare:612.03IWP-O1
CAS:<p>IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.</p>Formula:C26H20N6OPurezza:99.12%Colore e forma:SolidPeso molecolare:432.48S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Formula:C16H15NO7SPurezza:97.83%Colore e forma:SolidPeso molecolare:365.36BDP5290
CAS:<p>BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)</p>Formula:C17H18ClN7OPurezza:97.22%Colore e forma:SolidPeso molecolare:371.82BIO-013077-01
CAS:<p>BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.</p>Formula:C17H13N5Purezza:99.87%Colore e forma:SolidPeso molecolare:287.32CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Formula:C19H15N3O2Purezza:96.14% - 99.16%Colore e forma:SolidPeso molecolare:317.34Filgotinib
CAS:<p>Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.</p>Formula:C21H23N5O3SPurezza:98.03% - ≥95%Colore e forma:SolidPeso molecolare:425.5KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formula:C16H11BrN2OPurezza:97.14% - 98.99%Colore e forma:Tan SolidPeso molecolare:327.18SAR-20347
CAS:<p>SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).</p>Formula:C21H18ClFN4O4Purezza:98.99% - 99.77%Colore e forma:SolidPeso molecolare:444.84ROCK-IN-2
CAS:<p>ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.</p>Formula:C18H13ClF2N6OPurezza:97.29%Colore e forma:SolidPeso molecolare:402.79IWP-2
CAS:<p>IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.</p>Formula:C22H18N4O2S3Purezza:96.1% - 99.49%Colore e forma:SolidPeso molecolare:466.6Abrocitinib
CAS:<p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>Formula:C14H21N5O2SPurezza:99.09% - 99.91%Colore e forma:SolidPeso molecolare:323.41Peficitinib
CAS:<p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>Formula:C18H22N4O2Purezza:98.67% - 99.4%Colore e forma:SolidPeso molecolare:326.39(E)-SIS3
CAS:<p>(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!</p>Formula:C28H27N3O3·HClPurezza:95.64% - 98%Colore e forma:SolidPeso molecolare:489.99LY900009
CAS:<p>LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.</p>Formula:C23H27N3O4Purezza:97.07%Colore e forma:SolidPeso molecolare:409.48Crenigacestat
CAS:<p>Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested.</p>Formula:C22H23F3N4O4Purezza:97.27% - 98.99%Colore e forma:SolidPeso molecolare:464.44CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Formula:C11H14Cl3N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:358.67Wnt-C59
CAS:<p>Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.</p>Formula:C25H21N3OPurezza:99.56% - 99.95%Colore e forma:SolidPeso molecolare:379.45Indirubin-3'-monoxime
CAS:<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Formula:C16H11N3O2Purezza:99.55%Colore e forma:Dark Red SolidPeso molecolare:277.28AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Formula:C17H16ClN3OPurezza:98.04% - ≥95%Colore e forma:SolidPeso molecolare:313.78CEP-33779
CAS:<p>CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.</p>Formula:C24H26N6O2SPurezza:98.24% - ≥95%Colore e forma:SolidPeso molecolare:462.57SRI-011381 hydrochloride
CAS:<p>SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formula:C20H32ClN3OPurezza:99.32% - 99.41%Colore e forma:SolidPeso molecolare:365.94FLLL32
CAS:<p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).</p>Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.55Gusacitinib HCl
CAS:<p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>Formula:C24H29ClN8O2Colore e forma:SolidPeso molecolare:497SR-3029
CAS:<p>SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.</p>Formula:C23H19F3N8OPurezza:99.64%Colore e forma:SolidPeso molecolare:480.45Fosciclopirox
CAS:<p>Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire</p>Formula:C13H20NO6PPurezza:99.83%Colore e forma:SolidPeso molecolare:317.27RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Formula:C17H14Cl2N6OPurezza:97.94%Colore e forma:SolidPeso molecolare:389.24(E/Z)-Zotiraciclib
CAS:<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>Formula:C23H24N4OPurezza:97.75% - 99.92%Colore e forma:SolidPeso molecolare:372.46Y-27632 dihydrochloride
CAS:<p>View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.</p>Formula:C14H21N3O·2HClPurezza:97.96% - 99.98%Colore e forma:SolidPeso molecolare:320.26Pyrvinium pamoate
CAS:<p>Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug</p>Formula:C26H28N3C23H14O6Purezza:99.76% - >99.99%Colore e forma:SolidPeso molecolare:575.71Baricitinib phosphate
CAS:<p>Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.</p>Formula:C16H20N7O6PSPurezza:99.4% - 99.82%Colore e forma:SolidPeso molecolare:469.41Fz7-21
CAS:<p>Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.</p>Formula:C83H114N18O23S2Purezza:99.8%Colore e forma:SolidPeso molecolare:1796.03G5-7
CAS:<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39Decernotinib
CAS:<p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>Formula:C18H19F3N6OPurezza:99.28% - >99.99%Colore e forma:SolidPeso molecolare:392.38JANEX-1
CAS:<p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>Formula:C16H15N3O3Purezza:98% - 99.81%Colore e forma:SolidPeso molecolare:297.31γ-secretase modulator 1 hydrochloride
CAS:<p>gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].</p>Formula:C24H25ClN4OSPurezza:98%Colore e forma:SolidPeso molecolare:453Gandotinib
CAS:<p>LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).</p>Formula:C23H25ClFN7OPurezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:469.94Ritlecitinib tosylate
CAS:<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formula:C22H27N5O4SColore e forma:SolidPeso molecolare:457.549AMG-47a
CAS:<p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>Formula:C29H28F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:535.56RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63IWR-1
CAS:<p>IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).</p>Formula:C25H19N3O3Purezza:99.19% - 99.82%Colore e forma:SolidPeso molecolare:409.44DMAT
CAS:<p>DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).</p>Formula:C9H7Br4N3Purezza:99.48%Colore e forma:SolidPeso molecolare:476.79IQ 1
CAS:<p>IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.</p>Formula:C21H22N4O2Purezza:98.57% - ≥95%Colore e forma:SolidPeso molecolare:362.42PF-06651600 malonate
CAS:<p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>Formula:C18H23N5O5Colore e forma:SolidPeso molecolare:389.41JAK3-IN-6
CAS:<p>JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM</p>Formula:C19H18N4O3Purezza:99.94% - 99.94%Colore e forma:SolidPeso molecolare:350.37ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formula:C23H25NO·HClPurezza:98.05%Colore e forma:SolidPeso molecolare:367.91AS-252424
CAS:<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Formula:C14H8FNO4SPurezza:99.06% - 99.09%Colore e forma:SolidPeso molecolare:305.28Ruxolitinib (S enantiomer)
CAS:<p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>Formula:C17H18N6Purezza:99.37% - 99.79%Colore e forma:SolidPeso molecolare:306.36Fedratinib hydrochloride hydrate
CAS:<p>Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.</p>Formula:C27H40Cl2N6O4SPurezza:98.96% - 99.87%Colore e forma:SolidPeso molecolare:615.61
