Cellule staminali e Derivati
Gli inibitori delle cellule staminali sono composti che bersagliano specificamente le vie di segnalazione e le proteine coinvolte nel mantenimento, nella differenziazione e nella proliferazione delle cellule staminali. Questi inibitori sono cruciali per comprendere la biologia delle cellule staminali e per sviluppare strategie per manipolare le cellule staminali a fini terapeutici, come la medicina rigenerativa e il trattamento del cancro. Controllando il destino delle cellule staminali, questi inibitori possono aiutare a guidare la differenziazione delle cellule staminali in tipi cellulari specifici o a prevenire una crescita cellulare indesiderata. Presso CymitQuimica, offriamo una selezione di inibitori delle cellule staminali di alta qualità per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e medicina rigenerativa.
Sottocategorie di "Cellule staminali e Derivati"
- Gamma-secretasi(59 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Via di segnalazione Hippo(6 prodotti)
- JAK(245 prodotti)
- Proteina Porcupine(9 prodotti)
- ROCK(70 prodotti)
- STAT(98 prodotti)
- Cellule staminali(486 prodotti)
- TGF-beta/Smad(58 prodotti)
- Wnt/beta-catenina(66 prodotti)
Mostrare 2 più sottocategorie
Trovati 695 prodotti di "Cellule staminali e Derivati"
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BRD0209
CAS:<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formula:C22H25N3OPurezza:99.92%Colore e forma:SolidPeso molecolare:347.45JI051
CAS:<p>JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.</p>Formula:C22H24N2O3Purezza:≥98% - ≥98.0%Colore e forma:SolidPeso molecolare:364.44SB-772077B dihydrochloride
CAS:<p>SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).</p>Formula:C15H20Cl2N8O2Purezza:98%Colore e forma:SolidPeso molecolare:415.28Jaspamycin
CAS:<p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>Formula:C12H12N4O5Colore e forma:SolidPeso molecolare:292.25(Rac)-SIS3 free base
CAS:<p>SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.</p>Formula:C28H27N3O3Purezza:98%Colore e forma:SolidPeso molecolare:453.53GSK-3β inhibitor 12
CAS:<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Formula:C14H13N3OSPurezza:98.58%Colore e forma:SolidPeso molecolare:271.34AF-2112
<p>AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.</p>Formula:C21H18FNO3Purezza:98%Colore e forma:SolidPeso molecolare:351.37SD-1029
CAS:<p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>Formula:C25H32Br2Cl2N2O3Colore e forma:SolidPeso molecolare:639.25FzM1.8
CAS:<p>FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.</p>Formula:C18H14N2O4Purezza:99.89%Colore e forma:SolidPeso molecolare:322.31LEQ506
CAS:<p>LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.</p>Formula:C25H32N6OPurezza:99.76%Colore e forma:SolidPeso molecolare:432.56JAK1-IN-8
CAS:<p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).</p>Formula:C22H23FN4O3SPurezza:98.4%Colore e forma:SolidPeso molecolare:442.51SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Formula:C14H14ClFN2O2Purezza:99.94%Colore e forma:SolidPeso molecolare:296.72IHMT-MST1-58
CAS:<p>IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.</p>Formula:C21H22N6O3SPurezza:98.31% - 99.92%Colore e forma:SolidPeso molecolare:438.5Rho-Kinase-IN-1
CAS:<p>Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.</p>Formula:C20H24N4SPurezza:99.8%Colore e forma:SolidPeso molecolare:352.5Butyzamide
CAS:<p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>Formula:C29H32Cl2N2O5SPurezza:99.51% - 99.83%Colore e forma:SoildPeso molecolare:591.55PI-828
CAS:<p>PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.</p>Formula:C19H18N2O3Purezza:99.95%Colore e forma:SolidPeso molecolare:322.36CRT0066854 hydrochloride
CAS:<p>CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.</p>Formula:C24H27Cl2N5SPurezza:99.63%Colore e forma:SolidPeso molecolare:488.48DIF-3
CAS:<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Formula:C13H17ClO4Purezza:99.57%Colore e forma:SolidPeso molecolare:272.72CID-5056270
CAS:<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Formula:C17H13N3O3SPurezza:99.6%Colore e forma:SolidPeso molecolare:339.37EHT 1610
CAS:<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Formula:C18H14FN5O2SPurezza:98.59%Colore e forma:SolidPeso molecolare:383.4BIP-135
CAS:<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Formula:C21H13BrN2O3Purezza:99.93%Colore e forma:SolidPeso molecolare:421.24JAK-STAT-IN-1
CAS:<p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>Formula:C21H21N5O2Purezza:99.59%Colore e forma:SolidPeso molecolare:375.42GSK-3β inhibitor 11
CAS:<p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>Formula:C20H15N3O4SPurezza:97.33%Colore e forma:SolidPeso molecolare:393.42Miclxin
CAS:<p>Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent</p>Formula:C26H27N5O2Purezza:99.17% - 99.99%Colore e forma:SolidPeso molecolare:441.52Wnt/β-catenin agonist 4
CAS:<p>Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.</p>Formula:C16H15FN4O2Purezza:99.61%Colore e forma:SolidPeso molecolare:314.31LM-41
CAS:<p>LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.</p>Formula:C19H14FNO2Purezza:99.73%Colore e forma:SolidPeso molecolare:307.32Casein kinase 1δ-IN-1
CAS:<p>Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.</p>Formula:C11H7N3OSPurezza:99.46%Colore e forma:SolidPeso molecolare:229.26GSK-3 Inhibitor XIII
CAS:<p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>Formula:C18H15N5Purezza:99.85% - 99.86%Colore e forma:SolidPeso molecolare:301.35ARN25068
CAS:<p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>Formula:C19H18N6SPurezza:99.75%Colore e forma:SolidPeso molecolare:362.45GSK-3β inhibitor 2
CAS:<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Formula:C14H14N4O3SPurezza:99.08%Colore e forma:SolidPeso molecolare:318.35Rhodblock 6
CAS:<p>Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.</p>Formula:C12H13N3OPurezza:98.27%Colore e forma:SolidPeso molecolare:215.25XL413 xHCl
CAS:<p>BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215</p>Formula:C14H12ClN3O2·xHClPurezza:99.37% - 99.67%Colore e forma:SolidPeso molecolare:326.18STS-E412
CAS:<p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>Formula:C15H15ClN4O2Purezza:99.01%Colore e forma:SolidPeso molecolare:318.76AS 1892802
CAS:<p>AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.</p>Formula:C20H19N3O2Purezza:99.86%Colore e forma:SolidPeso molecolare:333.38ABC1183
CAS:<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Formula:C18H14N4OSPurezza:98.92%Colore e forma:SolidPeso molecolare:334.39Izencitinib
CAS:<p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>Formula:C22H26N8Purezza:99.82%Colore e forma:SolidPeso molecolare:402.50TT-10
CAS:<p>TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.</p>Formula:C11H10FN3OS2Purezza:99.29%Colore e forma:SolidPeso molecolare:283.35FzM1
CAS:<p>FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)</p>Formula:C21H16N2O2SPurezza:99.37% - 99.89%Colore e forma:SolidPeso molecolare:360.43MSC-4106
CAS:<p>MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.</p>Formula:C18H12F3N3O2Purezza:99.89%Colore e forma:SoildPeso molecolare:359.3A 1070722
CAS:<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Formula:C17H13F3N4O2Purezza:99.9%Colore e forma:SolidPeso molecolare:362.31STAT6-IN-3
CAS:<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Formula:C32H35IN3O7PPurezza:98%Colore e forma:SolidPeso molecolare:731.51Antitumor agent-73
CAS:<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Formula:C50H82BrO4PPurezza:98%Colore e forma:SolidPeso molecolare:858.06Casein kinase 1δ-IN-5
CAS:<p>Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in</p>Formula:C16H11F3N2OSPurezza:98%Colore e forma:SolidPeso molecolare:336.33YAP-TEAD-IN-2
CAS:<p>YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)</p>Formula:C25H24ClFN2O4Purezza:98%Colore e forma:SolidPeso molecolare:470.92JAK-IN-31
CAS:<p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>Formula:C21H19N7O2S2Purezza:98%Colore e forma:SolidPeso molecolare:465.55Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formula:C42H70O12Purezza:98.46% - 99.13%Colore e forma:SolidPeso molecolare:7673,7-DMF
CAS:<p>3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.</p>Formula:C17H14O4Purezza:98%Colore e forma:SolidPeso molecolare:282.29BRD5648
CAS:<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Formula:C20H23N3OPurezza:99.89%Colore e forma:SolidPeso molecolare:321.42JAK-IN-17
<p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>Formula:C33H38F2N6O8Colore e forma:SolidPeso molecolare:684.69Tyk2-IN-9
CAS:<p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>Formula:C20H17N9Purezza:98%Colore e forma:SolidPeso molecolare:383.41inS3-54A18
CAS:<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Formula:C23H16ClNO2Purezza:99.68%Colore e forma:SolidPeso molecolare:373.83TCJL37
CAS:<p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>Formula:C17H11ClF2N4O2Colore e forma:SolidPeso molecolare:376.74JAK-IN-24
CAS:<p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>Formula:C20H25N5O2Colore e forma:SolidPeso molecolare:367.44Upadacitinib tartrate
CAS:<p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>Formula:C21H33F3N6O11Purezza:98%Colore e forma:SolidPeso molecolare:602.521JAK-IN-25
CAS:<p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>Formula:C19H17N5O4Purezza:98%Colore e forma:SolidPeso molecolare:379.37BT-GSI
<p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.</p>Formula:C26H46BrN5O10P2Colore e forma:SolidPeso molecolare:730.52JAK-IN-1
CAS:<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Formula:C20H24N6O2Purezza:98%Colore e forma:SolidPeso molecolare:380.44Tubulin/JAK2-IN-1
CAS:<p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>Formula:C22H20N6O3Colore e forma:SolidPeso molecolare:416.43Yhhu-3792 hydrochloride
CAS:<p>Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].</p>Formula:C24H25ClN4O2Colore e forma:SolidPeso molecolare:436.93JW 67
CAS:<p>JW 67 is an inhibitor of canonical Wnt pathway signaling.</p>Formula:C21H18N2O6Purezza:99.02%Colore e forma:SolidPeso molecolare:394.38TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formula:C27H25F3N4O4Purezza:99.39% - ≥98%Colore e forma:SolidPeso molecolare:526.51Lepzacitinib
CAS:<p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>Formula:C18H21N5O3Purezza:99.85%Colore e forma:SolidPeso molecolare:355.39ROCK2-IN-6 hydrochloride
CAS:<p>ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。</p>Formula:C26H22ClF2N7OPurezza:98%Colore e forma:SolidPeso molecolare:521.95TGFβ-IN-5
CAS:<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Formula:C20H16N4Purezza:99.29% - 99.5%Colore e forma:SolidPeso molecolare:312.37ROCK-IN-8
CAS:<p>ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,</p>Formula:C30H25FN4O4SPurezza:98%Colore e forma:SolidPeso molecolare:556.61Nezulcitinib
CAS:<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Formula:C30H37N7O2Colore e forma:SolidPeso molecolare:527.66Chroman 1
CAS:<p>Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).</p>Formula:C24H28N4O4Purezza:99.67% - 99.84%Colore e forma:SolidPeso molecolare:436.5BMS-932481
CAS:<p>BMS-932481 is a γ-secretase modulator.</p>Formula:C24H24FN7OColore e forma:SolidPeso molecolare:445.49GSK-3β inhibitor 8
CAS:<p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>Formula:C20H20ClN5OSPurezza:98.46%Colore e forma:SolidPeso molecolare:413.92JAK-IN-4
CAS:<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Formula:C18H21N4Na2O6PPurezza:98%Colore e forma:SolidPeso molecolare:466.341ROCK2-IN-2
CAS:<p>ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).</p>Formula:C18H12N6OSPurezza:99.65%Colore e forma:SolidPeso molecolare:360.39Casein kinase 1δ-IN-10
CAS:<p>Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).</p>Formula:C21H17N3O3Purezza:98%Colore e forma:SolidPeso molecolare:359.38FM-479
CAS:<p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>Formula:C25H26N6O2Purezza:98%Colore e forma:SolidPeso molecolare:442.523STAT3-IN-B9
CAS:<p>STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.</p>Formula:C20H13NO5SPurezza:98.19%Colore e forma:SolidPeso molecolare:379.39TP0427736
CAS:<p>TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.</p>Formula:C14H10N4S2Purezza:97.26%Colore e forma:SolidPeso molecolare:298.39ML115
CAS:<p>ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.</p>Formula:C15H15ClN2O4Purezza:99.97%Colore e forma:SolidPeso molecolare:322.74MRK-560
CAS:<p>MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.</p>Formula:C19H17ClF5NO4S2Purezza:98.87%Colore e forma:SolidPeso molecolare:517.92LX7101
CAS:<p>LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).</p>Formula:C23H29N7O3Purezza:99.08%Colore e forma:SolidPeso molecolare:451.52Itacnosertib (hydrocholide)
CAS:<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Formula:C26H29ClN8OColore e forma:SolidPeso molecolare:505.01BMS-983970
CAS:<p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>Formula:C26H26F4N4O3Colore e forma:SolidPeso molecolare:518.5Stafib-2
CAS:<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Formula:C28H26N2O12P2Purezza:98.48%Colore e forma:SolidPeso molecolare:644.46GSM-1
CAS:<p>GSM-1 is a modulator of γ-Secretase.</p>Formula:C26H31ClF3NO2Colore e forma:SolidPeso molecolare:481.98ABBV-712
CAS:<p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>Formula:C24H28N4O5Purezza:98%Colore e forma:SolidPeso molecolare:452.5SWTX-143
CAS:<p>SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional</p>Formula:C19H18F3N3OPurezza:98%Colore e forma:SolidPeso molecolare:361.36DT-6
CAS:<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Formula:C89H130N20O29S2Purezza:98%Colore e forma:SolidPeso molecolare:2008.23QL-1200186
CAS:<p>QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following</p>Formula:C26H27N7O3Purezza:98%Colore e forma:SolidPeso molecolare:485.54JAK kinase-IN-1
CAS:<p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>Formula:C17H19F2N7OSPurezza:98%Colore e forma:SolidPeso molecolare:407.44Casein kinase 1δ-IN-4
CAS:<p>"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1]."</p>Formula:C16H12N6SPurezza:98%Colore e forma:SolidPeso molecolare:320.37Myristoyl tetrapeptide-12
CAS:<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Formula:C32H63N7O5Purezza:98%Colore e forma:SolidPeso molecolare:625.89ROCK-IN-7
CAS:<p>ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].</p>Formula:C17H17N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:327.4Brepocitinib
CAS:<p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>Formula:C18H21F2N7OPurezza:99.82%Colore e forma:SolidPeso molecolare:389.4JAK-IN-26
CAS:<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Formula:C22H24N6O3Purezza:98%Colore e forma:SolidPeso molecolare:420.46JAK-IN-5
CAS:<p>JAK-IN-5 is a JAK inhibitor.</p>Formula:C27H31FN6OPurezza:98.1% - 99.37%Colore e forma:SolidPeso molecolare:474.57Casein Kinase II Inhibitor IV
CAS:<p>Casein kinase II inhibitor IV is an effective small molecule inducer, which can be used to induce epidermal keratinocyte differentiation.</p>Formula:C24H23N5O3Purezza:99.65% - 99.75%Colore e forma:SolidPeso molecolare:429.47JAK2-IN-4
CAS:<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Formula:C23H27N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:469.56STAT3-IN-20
CAS:<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Formula:C30H27F4N7SPurezza:98%Colore e forma:SolidPeso molecolare:593.64STAT6-IN-2
CAS:<p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>Formula:C28H31N5O2Purezza:99.67%Colore e forma:SolidPeso molecolare:469.58H-1152 dihydrochloride
CAS:<p>H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.</p>Formula:C16H23Cl2N3O2SPurezza:99.85%Colore e forma:SolidPeso molecolare:392.34GNE-7883
CAS:<p>GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.</p>Formula:C28H29FN6O2Purezza:97.61%Colore e forma:SolidPeso molecolare:500.57Gossypolone
CAS:<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Formula:C30H26O10Purezza:96.66%Colore e forma:SolidPeso molecolare:546.52
