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Cellule staminali e Derivati

Cellule staminali e Derivati

Gli inibitori delle cellule staminali sono composti che bersagliano specificamente le vie di segnalazione e le proteine coinvolte nel mantenimento, nella differenziazione e nella proliferazione delle cellule staminali. Questi inibitori sono cruciali per comprendere la biologia delle cellule staminali e per sviluppare strategie per manipolare le cellule staminali a fini terapeutici, come la medicina rigenerativa e il trattamento del cancro. Controllando il destino delle cellule staminali, questi inibitori possono aiutare a guidare la differenziazione delle cellule staminali in tipi cellulari specifici o a prevenire una crescita cellulare indesiderata. Presso CymitQuimica, offriamo una selezione di inibitori delle cellule staminali di alta qualità per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e medicina rigenerativa.

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Trovati 694 prodotti di "Cellule staminali e Derivati"

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  • H-1152 dihydrochloride
    Targetmol
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    H-1152 dihydrochloride

    CAS:
    <p>H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.</p>
    Formula:C16H23Cl2N3O2S
    Purezza:99.85%
    Colore e forma:Solid
    Peso molecolare:392.34

    Ref: TM-T35328

  • STAT6-IN-2
    Targetmol
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    STAT6-IN-2

    CAS:
    <p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>
    Formula:C28H31N5O2
    Purezza:99.67%
    Colore e forma:Solid
    Peso molecolare:469.58

    Ref: TM-T79185

  • GSK-3 inhibitor 1
    Targetmol
    + Info

    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Formula:C22H17ClFN5O2
    Purezza:98.42%
    Colore e forma:Solid
    Peso molecolare:437.85

    Ref: TM-T11468

  • LNK01004
    Targetmol
    + Info

    LNK01004

    CAS:
    <p>LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.</p>
    Formula:C26H31N7O2
    Colore e forma:Solid
    Peso molecolare:473.57

    Ref: TM-T205387

  • Milpecitinib
    Targetmol
    + Info

    Milpecitinib

    CAS:
    <p>Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.</p>
    Formula:C20H20N4O2S
    Colore e forma:Solid
    Peso molecolare:380.463

    Ref: TM-T205326

  • TYK2 ligand 2
    Targetmol
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    TYK2 ligand 2

    CAS:
    <p>TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.</p>
    Formula:C24H20FN7O4
    Colore e forma:Solid
    Peso molecolare:489.458

    Ref: TM-T206678

  • TEAD-IN-20
    Targetmol
    + Info

    TEAD-IN-20

    CAS:
    <p>TEAD-IN-20 is a TEAD inhibitor with IC50 values of 0.021 μM in TEAD4 FRET and 0.044 μM in TEAD4 MCF7-Tead cell lines. It has potential applications in cancer research.</p>
    Formula:C20H19F3N4O3
    Colore e forma:Solid
    Peso molecolare:420.39

    Ref: TM-T207373

  • Logo CymitQuimica
    Targetmol
    + Info

    JAK-IN-19

    <p>JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).</p>
    Formula:C26H36FN5O2
    Colore e forma:Solid
    Peso molecolare:469.59

    Ref: TM-T63026

  • M3686
    Targetmol
    + Info

    M3686

    CAS:
    <p>M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.</p>
    Formula:C21H18F3N5O2
    Colore e forma:Solid
    Peso molecolare:429.395

    Ref: TM-T205477

  • lirucitinib
    Targetmol
    + Info

    lirucitinib

    CAS:
    <p>Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.</p>
    Formula:C16H25N5OS
    Colore e forma:Solid
    Peso molecolare:335.468

    Ref: TM-T205259

  • iBFAR2
    Targetmol
    + Info

    iBFAR2

    CAS:
    <p>iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.</p>
    Formula:C19H15F3N2O2
    Colore e forma:Solid
    Peso molecolare:360.33

    Ref: TM-T204531

  • CEE321
    Targetmol
    + Info

    CEE321

    CAS:
    <p>CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.</p>
    Formula:C18H16ClN5O
    Colore e forma:Solid
    Peso molecolare:353.806

    Ref: TM-T204824

  • TEAD-IN-1
    Targetmol
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    TEAD-IN-1

    CAS:
    <p>TEAD-IN-1 (Compound 2) is an effective inhibitor of TEAD auto-palmitoylation with an IC50 of 603 nM. It enhances the interaction between TEAD and VGLL4, while diminishing the interaction between YAP and TEAD. TEAD-IN-1 is applicable for cancer research.</p>
    Formula:C15H20F2N2O3S
    Colore e forma:Solid
    Peso molecolare:346.393

    Ref: TM-T204883

  • TGFβ1-IN-1
    Targetmol
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    TGFβ1-IN-1

    CAS:
    <p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>
    Formula:C22H24N2O3
    Purezza:99.89% - 99.89%
    Colore e forma:Solid
    Peso molecolare:364.438

    Ref: TM-T61389

  • JAK1-IN-16
    Targetmol
    + Info

    JAK1-IN-16

    <p>JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.</p>
    Formula:C20H15ClF3N3OS
    Colore e forma:Solid
    Peso molecolare:437.87

    Ref: TM-T201648

  • STAT3-IN-8
    Targetmol
    + Info

    STAT3-IN-8

    CAS:
    <p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>
    Formula:C19H7F7N2O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:444.26

    Ref: TM-T71550

  • ROCK/HDAC-IN-1
    Targetmol
    + Info

    ROCK/HDAC-IN-1

    <p>ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.</p>
    Formula:C19H22N4O3S
    Colore e forma:Solid
    Peso molecolare:386.47

    Ref: TM-T201708

  • MGD-28
    Targetmol
    + Info

    MGD-28

    CAS:
    <p>MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.</p>
    Formula:C33H34FN7O3
    Purezza:99.39%
    Colore e forma:Solid
    Peso molecolare:595.67

    Ref: TM-T201415

  • (R)-9b
    Targetmol
    + Info

    (R)-9b

    CAS:
    <p>(R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.</p>
    Formula:C20H27ClN6O
    Colore e forma:Solid
    Peso molecolare:402.92

    Ref: TM-T201776

  • (+)-ITD-1
    Targetmol
    + Info

    (+)-ITD-1

    CAS:
    <p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>
    Formula:C27H29NO3
    Colore e forma:Solid
    Peso molecolare:415.52

    Ref: TM-T201672