Cellule staminali e Derivati
Gli inibitori delle cellule staminali sono composti che bersagliano specificamente le vie di segnalazione e le proteine coinvolte nel mantenimento, nella differenziazione e nella proliferazione delle cellule staminali. Questi inibitori sono cruciali per comprendere la biologia delle cellule staminali e per sviluppare strategie per manipolare le cellule staminali a fini terapeutici, come la medicina rigenerativa e il trattamento del cancro. Controllando il destino delle cellule staminali, questi inibitori possono aiutare a guidare la differenziazione delle cellule staminali in tipi cellulari specifici o a prevenire una crescita cellulare indesiderata. Presso CymitQuimica, offriamo una selezione di inibitori delle cellule staminali di alta qualità per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e medicina rigenerativa.
Sottocategorie di "Cellule staminali e Derivati"
- Gamma-secretasi(59 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Via di segnalazione Hippo(6 prodotti)
- JAK(245 prodotti)
- Proteina Porcupine(9 prodotti)
- ROCK(70 prodotti)
- STAT(98 prodotti)
- Cellule staminali(486 prodotti)
- TGF-beta/Smad(58 prodotti)
- Wnt/beta-catenina(66 prodotti)
Mostrare 2 più sottocategorie
Trovati 695 prodotti di "Cellule staminali e Derivati"
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IQ 1
CAS:<p>IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.</p>Formula:C21H22N4O2Purezza:98.57% - ≥95%Colore e forma:SolidPeso molecolare:362.42URMC-099
CAS:<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Formula:C27H27N5Purezza:99.32% - 99.98%Colore e forma:SolidPeso molecolare:421.54ROCK-IN-2
CAS:<p>ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.</p>Formula:C18H13ClF2N6OPurezza:97.29%Colore e forma:SolidPeso molecolare:402.79(Z)-LFM-A13
CAS:<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Formula:C11H8Br2N2O2Purezza:99.88%Colore e forma:SolidPeso molecolare:360VP3.15 dihydrobromide
CAS:<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Formula:C20H24Br2N4OSPurezza:99.67% - ≥95%Colore e forma:SolidPeso molecolare:528.3LGK974
CAS:<p>LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.</p>Formula:C23H20N6OPurezza:98.8% - >99.99%Colore e forma:SolidPeso molecolare:396.44PF-670462
CAS:<p>PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.</p>Formula:C19H22Cl2FN5Purezza:99.42% - 99.72%Colore e forma:SolidPeso molecolare:410.32Cardiogenol C hydrochloride
CAS:<p>Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).</p>Formula:C13H17ClN4O2Purezza:99.89% - 99.94%Colore e forma:SolidPeso molecolare:296.75KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formula:C17H11Cl2N3O2Purezza:98.06%Colore e forma:SolidPeso molecolare:360.19MYF-01-37
CAS:<p>MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.</p>Formula:C15H17F3N2OPurezza:99.46% - 99.5%Colore e forma:SolidPeso molecolare:298.3AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formula:C19H23N7O2Purezza:99.83% - 99.98%Colore e forma:SolidPeso molecolare:381.43BML-284
CAS:<p>BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.</p>Formula:C19H18N4O3Purezza:99.91% - 99.921%Colore e forma:SolidPeso molecolare:350.37WDR5-0103 hydrochloride[890190-22-4(free base)]
<p>WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:</p>Formula:C21H26ClN3O4Purezza:99.66%Colore e forma:SolidPeso molecolare:419.9AZ960
CAS:<p>AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).</p>Formula:C18H16F2N6Purezza:96.02% - 98.51%Colore e forma:SolidPeso molecolare:354.36Galunisertib
CAS:<p>Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C22H19N5OPurezza:97.09% - 99.98%Colore e forma:SolidPeso molecolare:369.42WP1066
CAS:<p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>Formula:C17H14BrN3OPurezza:98.92% - 99.73%Colore e forma:SolidPeso molecolare:356.22CEP-33779
CAS:<p>CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.</p>Formula:C24H26N6O2SPurezza:98.24% - ≥95%Colore e forma:SolidPeso molecolare:462.57Baricitinib phosphate
CAS:<p>Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.</p>Formula:C16H20N7O6PSPurezza:99.4% - 99.82%Colore e forma:SolidPeso molecolare:469.41WHI-P97 HCl
<p>WHI-P97 HCl is a potent and selective JAK-3 inhibitor.</p>Formula:C16H14Br2ClN3O3Purezza:99.49%Colore e forma:SolidPeso molecolare:491.56SJ000291942
CAS:<p>SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.</p>Formula:C16H15FN2O4Purezza:99.66%Colore e forma:SolidPeso molecolare:318.3ZINC00881524
CAS:<p>ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.</p>Formula:C21H20N2O3SPurezza:99.48%Colore e forma:SolidPeso molecolare:380.46IWP-2
CAS:<p>IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.</p>Formula:C22H18N4O2S3Purezza:96.1% - 99.49%Colore e forma:SolidPeso molecolare:466.6Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formula:C16H11N3O2Purezza:98.34%Colore e forma:SolidPeso molecolare:277.283,5-Bis(4-nitrophenoxy)benzoic acid
CAS:<p>3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It decreases the released levels of Aβ42 and notch-1 Aβ-like peptide 25.</p>Formula:C19H12N2O8Purezza:99.14%Colore e forma:SolidPeso molecolare:396.31Abrocitinib
CAS:<p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>Formula:C14H21N5O2SPurezza:99.09% - 99.91%Colore e forma:SolidPeso molecolare:323.41ITD-1
CAS:<p>ITD-1 is a potent and highly selective TGFβ pathway inhibitor.</p>Formula:C27H29NO3Purezza:99.89% - >99.99%Colore e forma:SolidPeso molecolare:415.52LF3
CAS:<p>LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)</p>Formula:C20H24N4O2S2Purezza:99.63%Colore e forma:SolidPeso molecolare:416.56TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formula:C6HBr4N3Purezza:98.51% - 99.45%Colore e forma:Off-White SolidPeso molecolare:434.71LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
<p>LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .</p>Formula:C25H44F6N6O9Purezza:99.75%Colore e forma:SolidPeso molecolare:686.64Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formula:C14H18ClN3O2SPurezza:99.54% - ≥95%Colore e forma:White SolidPeso molecolare:327.83Kartogenin
CAS:<p>Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.</p>Formula:C20H15NO3Purezza:96.25% - 97.79%Colore e forma:SolidPeso molecolare:317.34SC99
CAS:<p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>Formula:C15H8Cl2FN3OPurezza:99.56%Colore e forma:SolidPeso molecolare:336.15Thiazovivin
CAS:<p>Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.</p>Formula:C15H13N5OSPurezza:98.00%Colore e forma:SolidPeso molecolare:311.36Tideglusib
CAS:<p>Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.</p>Formula:C19H14N2O2SPurezza:98.40% - 99.35%Colore e forma:SolidPeso molecolare:334.39FLI-06
CAS:<p>FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).</p>Formula:C25H30N2O5Purezza:99.81% - ≥98%Colore e forma:SolidPeso molecolare:438.52Pacritinib
CAS:<p>Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).</p>Formula:C28H32N4O3Purezza:99.25% - 99.49%Colore e forma:SolidPeso molecolare:472.58LY2090314
CAS:<p>LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.</p>Formula:C28H25FN6O3Purezza:99.21% - 99.91%Colore e forma:SolidPeso molecolare:512.53RKI-1447
CAS:<p>RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.</p>Formula:C16H14N4O2SPurezza:98% - 99.73%Colore e forma:SolidPeso molecolare:326.37BMP signaling agonist sb4
CAS:<p>BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)</p>Formula:C14H10BrNOSPurezza:99.48% - 99.805%Colore e forma:SolidPeso molecolare:320.2BMS986260
CAS:<p>BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).</p>Formula:C18H12ClFN6OPurezza:97.67%Colore e forma:SolidPeso molecolare:382.78Fedratinib
CAS:<p>Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.</p>Formula:C27H36N6O3SPurezza:97.31% - 99.96%Colore e forma:SolidPeso molecolare:524.68Tofacitinib Citrate
CAS:<p>Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).</p>Formula:C22H28N6O8Purezza:99.19% - 99.75%Colore e forma:SolidPeso molecolare:504.49Epiblastin A
CAS:<p>Epiblastin A inhibits CK1, targets its isoenzymes, and converts EpiSCs to cESCs.</p>Formula:C12H10ClN7Purezza:99.45%Colore e forma:SolidPeso molecolare:287.71Ruxolitinib (S enantiomer)
CAS:<p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>Formula:C17H18N6Purezza:99.37% - 99.79%Colore e forma:SolidPeso molecolare:306.36KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formula:C16H11BrN2OPurezza:97.14% - 98.99%Colore e forma:Tan SolidPeso molecolare:327.18BIO-013077-01
CAS:<p>BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.</p>Formula:C17H13N5Purezza:99.87%Colore e forma:SolidPeso molecolare:287.32IWP-O1
CAS:<p>IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.</p>Formula:C26H20N6OPurezza:99.12%Colore e forma:SolidPeso molecolare:432.48Tegatrabetan
CAS:<p>Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.</p>Formula:C28H36N4O6S2Purezza:98.01% - 99.18%Colore e forma:SolidPeso molecolare:588.74GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formula:C16H11N5O2SPurezza:98.86%Colore e forma:SolidPeso molecolare:337.36SH-4-54
CAS:<p>SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.</p>Formula:C29H27F5N2O5SPurezza:98% - 99.12%Colore e forma:SolidPeso molecolare:610.59AZD1080
CAS:<p>AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.</p>Formula:C19H18N4O2Purezza:97.72% - 99.75%Colore e forma:SolidPeso molecolare:334.37XMU-MP-1
CAS:<p>XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!</p>Formula:C17H16N6O3S2Purezza:99.68% - 99.79%Colore e forma:SolidPeso molecolare:416.48Teplinovivint
CAS:<p>Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy</p>Formula:C25H26N6O2Purezza:97.21%Colore e forma:SolidPeso molecolare:442.51CMD178 TFA
<p>CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.</p>Formula:C48H60F3N9O9Purezza:>99.99%Colore e forma:SolidPeso molecolare:964.05Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Formula:C30H42O7Purezza:96.69% - 99.8%Colore e forma:SolidPeso molecolare:514.65iCRT 14
CAS:<p>iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).</p>Formula:C21H17N3O2SPurezza:99.8% - 99.97%Colore e forma:SolidPeso molecolare:375.44Ruxolitinib phosphate
CAS:<p>Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.</p>Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36Porcn-IN-1
CAS:<p>Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).</p>Formula:C25H19FN4OPurezza:99.15%Colore e forma:SolidPeso molecolare:410.44Adavivint
CAS:<p>Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.</p>Formula:C29H24FN7OPurezza:98.27% - 98.6%Colore e forma:SolidPeso molecolare:505.55CHIR-99021
CAS:<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Formula:C22H18Cl2N8Purezza:97.94% - ≥95%Colore e forma:SolidPeso molecolare:465.34Jagged-1 (188-204) TFA(219127-21-6 free base)
<p>Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.</p>Formula:C95H128F3N25O28S3Purezza:99.48%Colore e forma:SolidPeso molecolare:2221.37KYA1797K
CAS:<p>KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.</p>Formula:C17H11N2O6S2·KPurezza:97.57% - 99.33%Colore e forma:SolidPeso molecolare:442.51DMAT
CAS:<p>DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).</p>Formula:C9H7Br4N3Purezza:99.48%Colore e forma:SolidPeso molecolare:476.79SRI-011381 hydrochloride
CAS:<p>SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formula:C20H32ClN3OPurezza:99.32% - 99.41%Colore e forma:SolidPeso molecolare:365.94KY02111
CAS:<p>KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.</p>Formula:C18H17ClN2O3SPurezza:97.71% - 98.3%Colore e forma:SolidPeso molecolare:376.86GSK-25
CAS:<p>GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.</p>Formula:C24H16Cl2F2N6OPurezza:98.59%Colore e forma:SolidPeso molecolare:513.33RO8191
CAS:<p>RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.</p>Formula:C14H5F6N5OPurezza:98% - 98.85%Colore e forma:SolidPeso molecolare:373.21Brevilin A
CAS:<p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>Formula:C20H26O5Purezza:99.97% - >99.99%Colore e forma:SolidPeso molecolare:346.42Silmitasertib
CAS:<p>Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).</p>Formula:C19H12ClN3O2Purezza:98% - 99.90%Colore e forma:SolidPeso molecolare:349.77IMR-1A
CAS:<p>IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formula:C13H11NO5S2Purezza:97.1% - 99.76%Colore e forma:SolidPeso molecolare:325.36JAK3-IN-6
CAS:<p>JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM</p>Formula:C19H18N4O3Purezza:99.94% - 99.94%Colore e forma:SolidPeso molecolare:350.37PF-06651600 malonate
CAS:<p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>Formula:C18H23N5O5Colore e forma:SolidPeso molecolare:389.41β-catenin-IN-2
CAS:<p>β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.</p>Formula:C15H14FN3Purezza:99.93%Colore e forma:SolidPeso molecolare:255.29RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63AMG-47a
CAS:<p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>Formula:C29H28F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:535.56Afuresertib hydrochloride
CAS:<p>Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)</p>Formula:C18H18Cl3FN4OSPurezza:99.96%Colore e forma:SolidPeso molecolare:463.8γ-secretase modulator 1 hydrochloride
CAS:<p>gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].</p>Formula:C24H25ClN4OSPurezza:98%Colore e forma:SolidPeso molecolare:453Decernotinib
CAS:<p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>Formula:C18H19F3N6OPurezza:99.28% - >99.99%Colore e forma:SolidPeso molecolare:392.38G5-7
CAS:<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39(E/Z)-Zotiraciclib
CAS:<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>Formula:C23H24N4OPurezza:97.75% - 99.92%Colore e forma:SolidPeso molecolare:372.46JAK-IN-5 hydrochloride
CAS:<p>JAK-IN-5 hydrochloride is a JAK inhibitor [1].</p>Formula:C27H32ClFN6OColore e forma:SolidPeso molecolare:511.03Gusacitinib HCl
CAS:<p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>Formula:C24H29ClN8O2Colore e forma:SolidPeso molecolare:497FLLL32
CAS:<p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).</p>Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.55AG490
CAS:<p>AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>Formula:C17H14N2O3Purezza:98.6% - 99.39%Colore e forma:Yellow SolidPeso molecolare:294.3Fedratinib hydrochloride hydrate
CAS:<p>Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.</p>Formula:C27H40Cl2N6O4SPurezza:98.96% - 99.87%Colore e forma:SolidPeso molecolare:615.61AZD-1480
CAS:<p>AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.</p>Formula:C14H14ClFN8Purezza:98.25% - 99.47%Colore e forma:SolidPeso molecolare:348.77Gandotinib
CAS:<p>LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).</p>Formula:C23H25ClFN7OPurezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:469.94SR-3029
CAS:<p>SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.</p>Formula:C23H19F3N8OPurezza:99.64%Colore e forma:SolidPeso molecolare:480.45IWP-4
CAS:<p>IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.</p>Formula:C23H20N4O3S3Purezza:98% - 99.59%Colore e forma:SolidPeso molecolare:496.62Oclacitinib
CAS:<p>Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000</p>Formula:C15H23N5O2SPurezza:98% - 98.45%Colore e forma:White To Off-White SolidPeso molecolare:337.44GSK269962A
CAS:<p>GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.</p>Formula:C29H30N8O5Purezza:99.14% - 99.71%Colore e forma:SolidPeso molecolare:570.6GDC-0214
CAS:<p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>Formula:C28H28ClF2N9O3Purezza:99.75%Colore e forma:SolidPeso molecolare:612.03Baricitinib
CAS:<p>Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.</p>Formula:C16H17N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:371.42JI130
CAS:<p>JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.</p>Formula:C23H24N2O3Purezza:99.61%Colore e forma:SolidPeso molecolare:376.45TTP 22
CAS:<p>TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.</p>Formula:C16H14N2O2S2Purezza:97.08% - 97.78%Colore e forma:SolidPeso molecolare:330.42Wnt-C59
CAS:<p>Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.</p>Formula:C25H21N3OPurezza:99.56% - 99.95%Colore e forma:SolidPeso molecolare:379.45I3MT-3
CAS:<p>I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.</p>Formula:C17H14N2O2SPurezza:99.76%Colore e forma:SolidPeso molecolare:310.37Oclacitinib maleate
CAS:<p>Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.</p>Formula:C15H23N5O2S·C4H4O4Purezza:99.17%Colore e forma:SolidPeso molecolare:453.51Filgotinib
CAS:<p>Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.</p>Formula:C21H23N5O3SPurezza:98.03% - ≥95%Colore e forma:SolidPeso molecolare:425.5SRI-011381
CAS:<p>SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formula:C20H31N3OPurezza:98.64%Colore e forma:SolidPeso molecolare:329.48Hydroxyfasudil
CAS:<p>Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).</p>Formula:C14H17N3O3SPurezza:98.13%Colore e forma:SolidPeso molecolare:307.37ML116
CAS:<p>ML116 is a potent and selective STAT3 inhibitor.</p>Formula:C18H19N3SPurezza:99.49%Colore e forma:SolidPeso molecolare:309.43BMS-911543
CAS:<p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>Formula:C23H28N8OPurezza:97.69% - 99.98%Colore e forma:SolidPeso molecolare:432.52NVP-BSK805 trihydrochloride
CAS:<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Formula:C27H31Cl3F2N6OColore e forma:SolidPeso molecolare:599.93PF-5274857
CAS:<p>PF-5274857: selective hedgehog pathway inhibitor (IC50: 5.8 nM, Ki: 4.6 nM), treats brain tumors, crosses blood-brain barrier, orally stable.</p>Formula:C20H25ClN4O3SPurezza:98.53%Colore e forma:SolidPeso molecolare:436.96BP-1-102
CAS:<p>BP-1-102 is an orally active, effective and specific STAT3 inhibitor.</p>Formula:C29H27F5N2O6SPurezza:99.25% - 99.44%Colore e forma:SolidPeso molecolare:626.59Fosifidancitinib
CAS:<p>Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.</p>Formula:C21H21FN5O7PPurezza:99.54%Colore e forma:SolidPeso molecolare:505.39Momelotinib HCl
CAS:<p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>Formula:C23H24Cl2N6O2Colore e forma:SolidPeso molecolare:487.38FM-381
CAS:<p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>Formula:C24H24N6O2Purezza:98.44%Colore e forma:SolidPeso molecolare:428.49AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Formula:C20H20ClN5O2Purezza:98.27% - 98.7%Colore e forma:SolidPeso molecolare:397.86TG101209
CAS:<p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>Formula:C26H35N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:509.67exo-IWR-1
CAS:<p>exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin</p>Formula:C25H19N3O3Purezza:97.41%Colore e forma:SolidPeso molecolare:409.44Cerdulatinib
CAS:<p>Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.</p>Formula:C20H27N7O3SPurezza:98.74% - 99.49%Colore e forma:SolidPeso molecolare:445.54Hydroxyfasudil Hydrochloride
CAS:<p>Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).</p>Formula:C14H18ClN3O3SPurezza:98.05%Colore e forma:SolidPeso molecolare:343.83Solcitinib
CAS:<p>Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.</p>Formula:C22H23N5O2Purezza:99.61% - 99.82%Colore e forma:SolidPeso molecolare:389.45Ritlecitinib
CAS:<p>Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.</p>Formula:C15H19N5OPurezza:98.82% - 99.92%Colore e forma:SolidPeso molecolare:285.34SH5-07
CAS:<p>SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).</p>Formula:C29H28F5N3O5SPurezza:95.54%Colore e forma:SolidPeso molecolare:625.61Upadacitinib
CAS:<p>Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.</p>Formula:C17H19F3N6OPurezza:98.96% - 99.94%Colore e forma:SolidPeso molecolare:380.37GSK429286A
CAS:<p>GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).</p>Formula:C21H16F4N4O2Purezza:97.68% - 98.49%Colore e forma:SolidPeso molecolare:432.37Pyridone 6
CAS:<p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>Formula:C18H16FN3OPurezza:97.1% - 98.74%Colore e forma:SolidPeso molecolare:309.34YO-01027
CAS:<p>YO-01027 (DBZ) is a potent γ-secretase inhibitor.</p>Formula:C26H23F2N3O3Purezza:97.21% - 99.58%Colore e forma:SolidPeso molecolare:463.48GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formula:C25H27FN6O4Purezza:98.68% - 99.40%Colore e forma:SolidPeso molecolare:494.52WHI-P97
CAS:<p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>Formula:C16H13Br2N3O3Purezza:99.93%Colore e forma:SolidPeso molecolare:455.1Belumosudil
CAS:<p>Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).</p>Formula:C26H24N6O2Purezza:97.64% - 98.59%Colore e forma:SolidPeso molecolare:452.51SR-3677
CAS:<p>SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).</p>Formula:C22H24N4O4Purezza:98.46%Colore e forma:SolidPeso molecolare:408.45(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formula:C14H10N2OPurezza:98.60%Colore e forma:SolidPeso molecolare:222.24Netarsudil mesylate
CAS:<p>Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.</p>Formula:C30H35N3O9S2Purezza:99.7%Colore e forma:SolidPeso molecolare:645.74TED-347
CAS:<p>TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.</p>Formula:C15H11ClF3NOPurezza:99.9%Colore e forma:SolidPeso molecolare:313.7SD-208
CAS:<p>SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.</p>Formula:C17H10ClFN6Purezza:98.72% - 99.65%Colore e forma:SolidPeso molecolare:352.75IWR-1
CAS:<p>IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).</p>Formula:C25H19N3O3Purezza:99.19% - 99.82%Colore e forma:SolidPeso molecolare:409.44Fz7-21
CAS:<p>Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.</p>Formula:C83H114N18O23S2Purezza:99.8%Colore e forma:SolidPeso molecolare:1796.03BD750
CAS:<p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>Formula:C14H13N3OSPurezza:99.02%Colore e forma:SolidPeso molecolare:271.34RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Formula:C17H14Cl2N6OPurezza:97.94%Colore e forma:SolidPeso molecolare:389.24Wnt pathway activator 1
CAS:<p>Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.</p>Formula:C18H16O4Purezza:99.93%Colore e forma:SolidPeso molecolare:296.32PF-4800567
CAS:<p>PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.</p>Formula:C17H18ClN5O2Purezza:99.76%Colore e forma:SolidPeso molecolare:359.81IWP L6
CAS:<p>IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).</p>Formula:C25H20N4O2S2Purezza:99.51% - >99.99%Colore e forma:SolidPeso molecolare:472.58FH535
CAS:<p>FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.</p>Formula:C13H10Cl2N2O4SPurezza:98.25% - 99.5%Colore e forma:SolidPeso molecolare:361.2Pacritinib hydrochloride
CAS:<p>Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.</p>Formula:C28H32N4O3·xClHColore e forma:Solid2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:<p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>Formula:C16H13Cl2N3O2Purezza:98.77%Colore e forma:SolidPeso molecolare:350.2Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Formula:C17H18N6Purezza:99.4% - >99.99%Colore e forma:SolidPeso molecolare:306.36Stafia-1
CAS:<p>Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.</p>Formula:C24H27O10PPurezza:98.08%Colore e forma:SolidPeso molecolare:506.44(E)-SIS3
CAS:<p>(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!</p>Formula:C28H27N3O3·HClPurezza:95.64% - 98%Colore e forma:SolidPeso molecolare:489.99MSAB
CAS:<p>MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.</p>Formula:C15H15NO4SPurezza:99.76%Colore e forma:SolidPeso molecolare:305.35Ritlecitinib tosylate
CAS:<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formula:C22H27N5O4SColore e forma:SolidPeso molecolare:457.549WAY-262611
CAS:<p>WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.</p>Formula:C20H22N4Purezza:98.09% - 99.09%Colore e forma:SolidPeso molecolare:318.42Cardiogenol C
CAS:<p>Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.</p>Formula:C13H16N4O2Purezza:98.46%Colore e forma:SolidPeso molecolare:260.29PF-04802367
CAS:<p>PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.</p>Formula:C16H16ClN5O3Purezza:98.76%Colore e forma:SolidPeso molecolare:361.78Y-27632 dihydrochloride
CAS:<p>View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.</p>Formula:C14H21N3O·2HClPurezza:97.96% - 99.98%Colore e forma:SolidPeso molecolare:320.26S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Formula:C16H15NO7SPurezza:97.83%Colore e forma:SolidPeso molecolare:365.36(E/Z)-GO289
CAS:<p>(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.</p>Formula:C17H15BrN4O2SPurezza:98.1%Colore e forma:SolidPeso molecolare:419.3IHR-1
CAS:<p>IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.</p>Formula:C20H12Cl4N2O2Purezza:97.02%Colore e forma:SolidPeso molecolare:454.13TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formula:C10H10N2O2SPurezza:97.13% - 99.61%Colore e forma:White SolidPeso molecolare:222.26ETC-159
CAS:<p>ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.</p>Formula:C19H17N7O3Purezza:96.87% - 99.30%Colore e forma:SolidPeso molecolare:391.38LH846
CAS:<p>LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.</p>Formula:C16H13ClN2OSPurezza:90% - 98.26%Colore e forma:SolidPeso molecolare:316.81Avagacestat
CAS:<p>Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM,</p>Formula:C20H17ClF4N4O4SPurezza:98.87% - 99.73%Colore e forma:SolidPeso molecolare:520.89MRT-14
CAS:<p>MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.</p>Formula:C24H24N4O5Purezza:99.54%Colore e forma:SolidPeso molecolare:448.47BML-284 hydrochloride
CAS:<p>BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.</p>Formula:C19H19ClN4O3Purezza:99.80%Colore e forma:SolidPeso molecolare:386.84BDP5290
CAS:<p>BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)</p>Formula:C17H18ClN7OPurezza:97.22%Colore e forma:SolidPeso molecolare:371.82SAR-20347
CAS:<p>SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).</p>Formula:C21H18ClFN4O4Purezza:98.99% - 99.77%Colore e forma:SolidPeso molecolare:444.84LY3200882
CAS:<p>LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).</p>Formula:C24H29N5O3Purezza:99.46% - 99.63%Colore e forma:SolidPeso molecolare:435.52Tofacitinib
CAS:<p>Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.</p>Formula:C16H20N6OPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:312.37WAY 316606
CAS:<p>WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.</p>Formula:C18H19F3N2O4S2Purezza:99.65%Colore e forma:SolidPeso molecolare:448.48Itacitinib
CAS:<p>Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.</p>Formula:C26H23F4N9OPurezza:96.4% - 99.5%Colore e forma:SolidPeso molecolare:553.51Afuresertib
CAS:<p>Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic</p>Formula:C18H17Cl2FN4OSPurezza:97.51% - 99.51%Colore e forma:SolidPeso molecolare:427.32RKI1313
CAS:<p>RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion</p>Formula:C17H16N4O2SPurezza:99.53% - ≥95%Colore e forma:SolidPeso molecolare:340.4AS-252424
CAS:<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Formula:C14H8FNO4SPurezza:99.06% - 99.09%Colore e forma:SolidPeso molecolare:305.28Deucravacitinib
CAS:<p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>Formula:C20H19D3N8O3Purezza:98.52% - >99.99%Colore e forma:SolidPeso molecolare:425.46Fosciclopirox
CAS:<p>Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire</p>Formula:C13H20NO6PPurezza:99.83%Colore e forma:SolidPeso molecolare:317.27Atractylenolide I
CAS:<p>Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.</p>Formula:C15H18O2Purezza:97.55% - 99.92%Colore e forma:SolidPeso molecolare:230.3SKL2001
CAS:<p>SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.</p>Formula:C14H14N4O3Purezza:97.46% - 99.5%Colore e forma:SolidPeso molecolare:286.29AR-A014418
CAS:<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Formula:C12H12N4O4SPurezza:>99.99% - ≥95%Colore e forma:SolidPeso molecolare:308.31GLPG0634 analog
CAS:<p>GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.</p>Formula:C23H18N6O2Purezza:99.52% - >99.99%Colore e forma:SolidPeso molecolare:410.43Lats-IN-1
CAS:<p>Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.</p>Formula:C18H14N4OSPurezza:97.54% - 99.79%Colore e forma:SolidPeso molecolare:334.39WHI-P154
CAS:<p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>Formula:C16H14BrN3O3Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:376.2SAR407899 hydrochloride
CAS:<p>SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and</p>Formula:C14H17ClN2O2Purezza:99.15%Colore e forma:SolidPeso molecolare:280.75IMR-1
CAS:<p>IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formula:C15H15NO5S2Purezza:97.96% - 98.38%Colore e forma:SolidPeso molecolare:353.41XL019
CAS:<p>XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.</p>Formula:C25H28N6O2Purezza:99.19%Colore e forma:SolidPeso molecolare:444.53AZD2858
CAS:<p>AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.</p>Formula:C21H23N7O3SPurezza:98% - 99.25%Colore e forma:SolidPeso molecolare:453.52SAR407899
CAS:<p>SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.</p>Formula:C14H16N2O2Purezza:99.42%Colore e forma:SolidPeso molecolare:244.29NCC007
CAS:<p>NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.</p>Formula:C22H28F3N7Purezza:98.88%Colore e forma:SolidPeso molecolare:447.5MLN8054
CAS:<p>MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.</p>Formula:C25H15ClF2N4O2Purezza:98.07% - 98.26%Colore e forma:SolidPeso molecolare:476.86MK-0752 Sodium
CAS:<p>Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.</p>Formula:C21H21ClF2NaO4SColore e forma:SolidPeso molecolare:465.89ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formula:C23H25NO·HClPurezza:98.05%Colore e forma:SolidPeso molecolare:367.91SB 216763
CAS:<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Formula:C19H12Cl2N2O2Purezza:98.9% - 99.13%Colore e forma:SolidPeso molecolare:371.22JANEX-1
CAS:<p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>Formula:C16H15N3O3Purezza:98% - 99.81%Colore e forma:SolidPeso molecolare:297.31SHR0302
CAS:<p>SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,</p>Formula:C18H22N8O2SPurezza:99.11%Colore e forma:SolidPeso molecolare:414.48Pyrvinium pamoate
CAS:<p>Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug</p>Formula:C26H28N3C23H14O6Purezza:99.76% - >99.99%Colore e forma:SolidPeso molecolare:575.71Peficitinib
CAS:<p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>Formula:C18H22N4O2Purezza:98.67% - 99.4%Colore e forma:SolidPeso molecolare:326.39LY900009
CAS:<p>LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.</p>Formula:C23H27N3O4Purezza:97.07%Colore e forma:SolidPeso molecolare:409.48CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Formula:C11H14Cl3N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:358.67Indirubin-3'-monoxime
CAS:<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Formula:C16H11N3O2Purezza:99.55%Colore e forma:Dark Red SolidPeso molecolare:277.28AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Formula:C17H16ClN3OPurezza:98.04% - ≥95%Colore e forma:SolidPeso molecolare:313.78Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formula:C15H12O5Purezza:99.42% - 99.82%Colore e forma:SolidPeso molecolare:272.25CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Formula:C19H15N3O2Purezza:96.14% - 99.16%Colore e forma:SolidPeso molecolare:317.34CHIR 98024
CAS:<p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>Formula:C20H17Cl2N9O2Purezza:96.74%Colore e forma:SolidPeso molecolare:486.31Mouse CC17(Clara Cell Protein) Microsample ELISA Kit
<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CC17. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CC17. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse CC17, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse CC17 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>Simian OC/BGP(Osteocalcin) ELISA Kit
<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian OC/BGP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian OC/BGP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian OC/BGP, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian OC/BGP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>Colore e forma:Colourless TransparentliquidRO7185876
CAS:<p>RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.</p>Formula:C25H28F3N7Purezza:99.50%Colore e forma:SolidPeso molecolare:483.532GS-829845
CAS:<p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>Formula:C17H19N5O2SPurezza:99.93%Colore e forma:SolidPeso molecolare:357.43
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