Gamma-secretasi
Gli inibitori della gamma-secretasi sono composti che prendono di mira il complesso enzimatico gamma-secretasi, coinvolto nella scissione della proteina precursore dell'amiloide (APP) per produrre peptidi beta-amiloidi. Questi peptidi possono aggregarsi per formare placche amiloidi, una caratteristica distintiva della malattia di Alzheimer. Inibendo la gamma-secretasi, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, diventando così un focus chiave nella ricerca sulla malattia di Alzheimer. Presso CymitQuimica, offriamo inibitori della gamma-secretasi per supportare la tua ricerca in biologia dell'amiloide, terapia dell'Alzheimer e malattie neurodegenerative.
Trovati 57 prodotti di "Gamma-secretasi"
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Rovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.02 kDaDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.34 kDaCB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Formula:C15H18N2OPurezza:99.44%Colore e forma:SolidPeso molecolare:242.32γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Formula:C25H23F3N4O2Colore e forma:SolidPeso molecolare:468.48BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Formula:C26H26F6N4O3Purezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:556.5PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Formula:C20H18ClFN2O3SColore e forma:SolidPeso molecolare:420.88Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Formula:C64H98N15F3O25S3Purezza:98%Colore e forma:SolidPeso molecolare:1614.81PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Formula:C20H19ClF3NO3SColore e forma:SolidPeso molecolare:445.88CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formula:C17H19N3O2SPurezza:99%Colore e forma:SolidPeso molecolare:329.42SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Formula:C27H28FN5O4Purezza:98%Colore e forma:SolidPeso molecolare:505.545β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Formula:C24H40O2Purezza:98.91% - 99.89%Colore e forma:SoildPeso molecolare:360.57SAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Formula:C96H163N36F3O25SColore e forma:SolidPeso molecolare:2310.6Notch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Formula:C62H97N15O22S3Colore e forma:SolidPeso molecolare:1500.72FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFormula:C22H22ClN5O2Colore e forma:SolidPeso molecolare:423.9SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Formula:C94H162N36O23SPurezza:98%Colore e forma:SolidPeso molecolare:2196.58RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFormula:C17H14FN3O2Purezza:99.79%Colore e forma:SoildPeso molecolare:311.31Ref: TM-T35566
1mg38,00€2mg50,00€5mg84,00€10mg130,00€25mg215,00€50mg371,00€100mg537,00€1mL*10mM (DMSO)93,00€Legumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Formula:C23H25N5O4SPurezza:98.14%Colore e forma:SolidPeso molecolare:467.54γ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Formula:C24H23FN4OSPurezza:98%Colore e forma:SolidPeso molecolare:434.53MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Formula:C21H21ClF2NaO4SColore e forma:SolidPeso molecolare:465.89LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formula:C23H27N3O4Purezza:97.07%Colore e forma:SolidPeso molecolare:409.48Ref: TM-T9015
1mg38,00€5mg85,00€10mg118,00€25mg207,00€50mg306,00€100mg444,00€200mg622,00€1mL*10mM (DMSO)93,00€
