Ubiquitinazione
Gli inibitori dell'ubiquitinazione sono composti che interferiscono con il processo di ubiquitinazione, in cui le proteine vengono etichettate con molecole di ubiquitina per essere degradate dal proteasoma. Questi inibitori sono fondamentali per studiare il turnover delle proteine, la trasduzione del segnale e la regolazione di vari processi cellulari. L'ubiquitinazione svolge un ruolo chiave in molte malattie, tra cui il cancro, i disturbi neurodegenerativi e le disfunzioni del sistema immunitario. Modulando l'ubiquitinazione, questi inibitori possono fornire approfondimenti sui meccanismi delle malattie e aprire nuove strade per l'intervento terapeutico. Presso CymitQuimica, offriamo un'ampia selezione di inibitori dell'ubiquitinazione di alta qualità per supportare la tua ricerca in biologia cellulare, proteomica e sviluppo di farmaci.
Sottocategorie di "Ubiquitinazione"
Trovati 65 prodotti per "Ubiquitinazione".
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WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Formula:C18H21Cl2N9S2Purezza:98.46%Colore e forma:SolidPeso molecolare:498.46Ref: TM-T13349
1mg43,00€2mg55,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg137,00€25mg268,00€50mg530,00€100mg755,00€500mg1.549,00€ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Formula:C21H23BrN6O5SPurezza:99.32% - 99.82%Colore e forma:SolidPeso molecolare:551.41Ref: TM-T16102
1mg87,00€2mg113,00€5mg177,00€1mL*10mM (DMSO)225,00€10mg260,00€25mg409,00€50mg560,00€100mg800,00€NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Formula:C6H7N3O3Purezza:97.72%Colore e forma:SolidPeso molecolare:169.14Antitumor agent-153
Antitumor agent-153 (compound 11b) is an inhibitor of H2A histone ubiquitination, optimized from PRT4165. It can reduce the viability of human osteosarcoma U2OS cells and decrease monoubiquitination of histone H2A, demonstrating anticancer activity.Formula:C16H8N2O6Colore e forma:SolidPeso molecolare:324.03824dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.Formula:C14H11ClN4OSPurezza:98.48% - 99.49%Colore e forma:SolidPeso molecolare:318.78Cbl-b-IN-19
Cbl-b-IN-19 (Compound 49) is an inhibitor of the E3 ligase Cbl-b, effectively suppressing its phosphorylation with an IC50 of less than 100 nM.Formula:C34H31F3N8OColore e forma:SolidPeso molecolare:624.25729Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Colore e forma:Odour SolidRef: TM-L8600
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaPost-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Colore e forma:Odour SolidRef: TM-L1620
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaSkp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Colore e forma:Odour SolidSAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Formula:C27H30ClN5O5S2Colore e forma:SolidPeso molecolare:603.13769Cbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Formula:C27H27N5O3Colore e forma:SolidPeso molecolare:469.21139Rugonersen sodium
CAS:Rugonersen sodium is a locked nucleic acid (LNA)-modified antisense oligonucleotide (ASO) designed to reduce the silencing of ubiquitin protein ligase E3A (UBE3A). Angelman syndrome (AS) refers to a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, and Rugonersen has been studied for its potential use in the treatment of AS.Formula:C204H235N63Na19O109P19S19Colore e forma:SolidPeso molecolare:6948.00Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Formula:C33H31F4N7OColore e forma:SolidPeso molecolare:617.25262RNF5 agonist 1
CAS:RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.Formula:C22H18N4SColore e forma:SolidPeso molecolare:370.47UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C17H17ClN4O2Colore e forma:SolidPeso molecolare:344.8UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formula:C20H15ClN2O5SColore e forma:SolidPeso molecolare:430.86UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C23H16ClN3O3SColore e forma:SolidPeso molecolare:449.91LS-102
CAS:LS-102: E3 ligase inhibitor, IC50 35 μM, potential RA therapy.Formula:C24H36N8OPurezza:98.92%Colore e forma:SolidPeso molecolare:452.6Ref: TM-T11879
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg145,00€25mg256,00€50mg409,00€100mg590,00€200mg827,00€MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formula:C29H29F3N2Colore e forma:SolidPeso molecolare:462.55GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formula:C28H19FN2O4Purezza:97.67%Colore e forma:SolidPeso molecolare:466.46Ref: TM-T25465
2mg35,00€5mg55,00€1mL*10mM (DMSO)57,00€10mg87,00€25mg161,00€50mg245,00€100mg358,00€200mg520,00€Subasumstat
CAS:Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Formula:C25H28ClN5O5S2Purezza:97.02% - 98.22%Colore e forma:SolidPeso molecolare:578.1DKM 2-93
CAS:DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Formula:C11H14ClNO3Purezza:98.37% - 99.39%Colore e forma:White SolidPeso molecolare:243.69TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formula:C9H2Cl4O2Purezza:98.87% - 99.34%Colore e forma:SolidPeso molecolare:283.92MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurezza:99.39%Colore e forma:SolidPeso molecolare:293.3Ref: TM-T8773
1mg52,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formula:C23H25ClN4OPurezza:99.91% - 99.97%Colore e forma:SolidPeso molecolare:408.92Skp2 Inhibitor C1
CAS:Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Formula:C18H13BrN2O4S2Purezza:97.36%Colore e forma:SolidPeso molecolare:465.34Ref: TM-T4253
2mg34,00€5mg52,00€1mL*10mM (DMSO)54,00€10mg85,00€25mg164,00€50mg264,00€100mg386,00€200mg537,00€WSB1 Degrader 1
CAS:WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Formula:C21H22N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:334.41ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Formula:C23H20N6OPurezza:99.73% - >99.99%Colore e forma:White SolidPeso molecolare:396.44Ref: TM-T3535
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg178,00€50mg295,00€100mg477,00€200mg677,00€BC-1382
CAS:BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Formula:C23H29N3O5SPurezza:99.15% - 99.94%Colore e forma:SolidPeso molecolare:459.56Ref: TM-T8564
1mg81,00€5mg170,00€1mL*10mM (DMSO)240,00€10mg250,00€25mg505,00€50mg730,00€100mg1.018,00€200mg1.369,00€NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formula:C27H28N4O3S2Purezza:99.05% - 99.85%Colore e forma:SolidPeso molecolare:520.67CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Formula:C23H27N3O4Purezza:98.02% - 99.48%Colore e forma:White SolidPeso molecolare:409.48ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formula:C12H22ClN3OSPurezza:99.3%Colore e forma:SolidPeso molecolare:291.84Ref: TM-T8931L
5mg34,00€1mL*10mM (DMSO)34,00€10mg50,00€25mg90,00€50mg138,00€100mg198,00€200mg296,00€500mg469,00€LANOSTEROL
CAS:Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Formula:C30H50OPurezza:97.99% - 99.67%Colore e forma:SolidPeso molecolare:426.72PR-619
CAS:PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Formula:C7H5N5S2Purezza:97.25% - >99.99%Colore e forma:White SolidPeso molecolare:223.28ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Formula:C23H24N4OPurezza:98%Colore e forma:SolidPeso molecolare:372.46COH000
CAS:COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Formula:C25H25NO5Purezza:99.23%Colore e forma:SolidPeso molecolare:419.47Ref: TM-T5199
1mg170,00€5mg371,00€1mL*10mM (DMSO)409,00€10mg537,00€25mg964,00€50mg1.333,00€100mg1.882,00€CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Formula:C24H23N5O2Purezza:95.95% - 99.92%Colore e forma:SolidPeso molecolare:413.47Ref: TM-T6796
1mg43,00€2mg56,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg130,00€25mg281,00€50mg444,00€100mg650,00€500mg1.369,00€BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFormula:C25H28N8Purezza:98.66%Colore e forma:Yellow ViscousPeso molecolare:440.54Ref: TM-T14569
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg260,00€25mg462,00€50mg655,00€100mg887,00€200mg1.198,00€FX12
CAS:FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Formula:C10H8O4SColore e forma:SolidPeso molecolare:224.23DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Formula:C19H13BrClNO5SPurezza:99.17%Colore e forma:SolidPeso molecolare:482.73Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFormula:C24H29ClN6O2Purezza:98%Colore e forma:SolidPeso molecolare:468.98CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Formula:C24H24N6OPurezza:97.66%Colore e forma:SoildPeso molecolare:412.49Cbl-b-IN-11
CAS:Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFormula:C31H35F5N6OPurezza:98%Colore e forma:SolidPeso molecolare:602.64CC0651
CAS:CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Formula:C20H21Cl2NO6Purezza:99.03%Colore e forma:White SolidPeso molecolare:442.29Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFormula:C30H33F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:566.62Cbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Formula:C28H29F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:538.56Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFormula:C29H31F4N5O2Purezza:98%Colore e forma:SolidPeso molecolare:557.58PYZD-4409
CAS:PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.Formula:C14H7ClFN3O5Purezza:99.71%Colore e forma:SolidPeso molecolare:351.67Skp2 inhibitor 2
CAS:Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Formula:C27H32N4OPurezza:98%Colore e forma:SolidPeso molecolare:428.57UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formula:C30H32F2N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:594.68
