Ubiquitinazione
Gli inibitori dell'ubiquitinazione sono composti che interferiscono con il processo di ubiquitinazione, in cui le proteine vengono etichettate con molecole di ubiquitina per essere degradate dal proteasoma. Questi inibitori sono fondamentali per studiare il turnover delle proteine, la trasduzione del segnale e la regolazione di vari processi cellulari. L'ubiquitinazione svolge un ruolo chiave in molte malattie, tra cui il cancro, i disturbi neurodegenerativi e le disfunzioni del sistema immunitario. Modulando l'ubiquitinazione, questi inibitori possono fornire approfondimenti sui meccanismi delle malattie e aprire nuove strade per l'intervento terapeutico. Presso CymitQuimica, offriamo un'ampia selezione di inibitori dell'ubiquitinazione di alta qualità per supportare la tua ricerca in biologia cellulare, proteomica e sviluppo di farmaci.
Sottocategorie di "Ubiquitinazione"
Trovati 107 prodotti di "Ubiquitinazione"
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DKM 2-93
CAS:DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Formula:C11H14ClNO3Purezza:98.37%Colore e forma:SolidPeso molecolare:243.69TCID
CAS:<p>TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.</p>Formula:C9H2Cl4O2Purezza:99.34%Colore e forma:SolidPeso molecolare:283.92USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Formula:C26H22F4N6OPurezza:99.69% - 99.88%Colore e forma:SolidPeso molecolare:510.486BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFormula:C25H28N8Purezza:98.66%Colore e forma:SolidPeso molecolare:440.54FX12
CAS:FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Formula:C10H8O4SPeso molecolare:224.23FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Formula:C27H28N6O5SPurezza:98.76%Colore e forma:SolidPeso molecolare:548.61DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Formula:C19H13BrClNO5SPurezza:99.17%Colore e forma:SolidPeso molecolare:482.73Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFormula:C24H29ClN6O2Purezza:98%Colore e forma:SolidPeso molecolare:468.98I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formula:C26H23F3N6OPurezza:99.41%Colore e forma:SolidPeso molecolare:492.5USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C23H20Cl2N2O3SPurezza:99.92%Colore e forma:SolidPeso molecolare:475.39USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C22H18Cl2N2O3SPurezza:98.48%Colore e forma:SolidPeso molecolare:461.36SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormula:C16H8N2O3Purezza:99.72%Colore e forma:SolidPeso molecolare:276.25USP22-IN-1
CAS:<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Formula:C22H18N4Purezza:98.2%Colore e forma:SolidPeso molecolare:338.41NAcM-OPT
CAS:NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).Formula:C23H29Cl2N3OPurezza:99.93%Colore e forma:SolidPeso molecolare:434.4CB-5339
CAS:<p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].</p>Formula:C24H24N6OPurezza:97.66%Colore e forma:SoildPeso molecolare:412.49GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formula:C17H12FN3Purezza:97.09%Colore e forma:SolidPeso molecolare:277.3OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formula:C22H16ClFN2O4Purezza:98.59%Colore e forma:SoildPeso molecolare:426.83P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formula:C12H9NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:279.33USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurezza:98.84% - 99.59%Colore e forma:SolidPeso molecolare:368.41LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurezza:97.12%Colore e forma:SolidPeso molecolare:314.32
