Ubiquitinazione
Gli inibitori dell'ubiquitinazione sono composti che interferiscono con il processo di ubiquitinazione, in cui le proteine vengono etichettate con molecole di ubiquitina per essere degradate dal proteasoma. Questi inibitori sono fondamentali per studiare il turnover delle proteine, la trasduzione del segnale e la regolazione di vari processi cellulari. L'ubiquitinazione svolge un ruolo chiave in molte malattie, tra cui il cancro, i disturbi neurodegenerativi e le disfunzioni del sistema immunitario. Modulando l'ubiquitinazione, questi inibitori possono fornire approfondimenti sui meccanismi delle malattie e aprire nuove strade per l'intervento terapeutico. Presso CymitQuimica, offriamo un'ampia selezione di inibitori dell'ubiquitinazione di alta qualità per supportare la tua ricerca in biologia cellulare, proteomica e sviluppo di farmaci.
Sottocategorie di "Ubiquitinazione"
Trovati 107 prodotti di "Ubiquitinazione"
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Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFormula:C29H31F4N5O2Purezza:98%Colore e forma:SolidPeso molecolare:557.58Skp2 inhibitor 2
CAS:Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Formula:C27H32N4OPurezza:98%Colore e forma:SolidPeso molecolare:428.57Cbl-b-IN-8
CAS:Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5Formula:C35H44F3N7O3Purezza:98%Colore e forma:SolidPeso molecolare:667.76Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Formula:C21H14F3N3O2SPurezza:98.396% - 99.88%Colore e forma:SolidPeso molecolare:429.42Cbl-b-IN-11
CAS:Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFormula:C31H35F5N6OPurezza:98%Colore e forma:SolidPeso molecolare:602.64CC0651
CAS:CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Formula:C20H21Cl2NO6Purezza:99.03%Colore e forma:SolidPeso molecolare:442.29USP7-IN-1
CAS:<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Formula:C23H24ClN3O3Purezza:99.82%Colore e forma:SolidPeso molecolare:425.91Cbl-b-IN-13
CAS:<p>Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].</p>Formula:C29H30F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:537.58Cbl-b-IN-6
CAS:Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Formula:C30H32F5N5OPurezza:98%Colore e forma:SolidPeso molecolare:573.6PYZD-4409
CAS:<p>PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.</p>Formula:C14H7ClFN3O5Purezza:99.71%Colore e forma:SolidPeso molecolare:351.67Cbl-b-IN-10
CAS:<p>Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (</p>Formula:C31H37F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:566.66Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFormula:C30H33F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:566.62FT671
CAS:<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Formula:C24H23F4N7O3Purezza:98%Colore e forma:SolidPeso molecolare:533.48UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formula:C30H32F2N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:594.68Cbl-b-IN-12
CAS:<p>Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100</p>Formula:C28H29F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:538.56IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formula:C23H19N5OPurezza:99.3%Colore e forma:SolidPeso molecolare:381.43UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFormula:C19H18N2OSPurezza:99.3%Colore e forma:SolidPeso molecolare:322.42PRC1-IN-1
CAS:<p>PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.</p>Formula:C24H19ClFN3O2Colore e forma:SolidPeso molecolare:435.878DCN1-UBC12-IN-4
CAS:DCN1-UBC12-IN-4 (compound 5p) is an inhibitor of DCN1-UBC12 (IC₅₀ > 10 μM), applicable for investigating cancer cell migration and invasion.Formula:C8H6ClN3SPurezza:98.32%Colore e forma:SolidPeso molecolare:211.67BC-1293
CAS:BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.Formula:C26H28N4O4SPurezza:98.40%Colore e forma:SolidPeso molecolare:492.59
