Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1494 prodotti di "Autofagia"
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Crenolanib
CAS:Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).Formula:C26H29N5O2Purezza:98.40% - 99.73%Colore e forma:SolidPeso molecolare:443.54SBI-0206965
CAS:SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
Formula:C21H21BrN4O5Purezza:99.13%Colore e forma:SolidPeso molecolare:489.32Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Formula:C18H22BrN5O3Purezza:98.86% - 99.87%Colore e forma:SolidPeso molecolare:436.3AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purezza:98.6% - 99.85%Colore e forma:Yellow SolidPeso molecolare:294.3ULK-101
CAS:ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.Formula:C22H16F4N4OSPurezza:97.55% - 99.94%Colore e forma:SolidPeso molecolare:460.45Ref: TM-T5403
1mg100,00€2mg149,00€5mg248,00€10mg356,00€25mg557,00€50mg712,00€100mg964,00€1mL*10mM (DMSO)250,00€Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Formula:C24H18F2N2O5Purezza:99.48% - 99.68%Colore e forma:SolidPeso molecolare:452.41PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Formula:C14H16N6OPurezza:99.06%Colore e forma:SolidPeso molecolare:284.32Ref: TM-T7729
2mg34,00€5mg52,00€10mg75,00€25mg128,00€50mg187,00€100mg290,00€200mg419,00€1mL*10mM (DMSO)52,00€Regorafenib mesylate
CAS:Regorafenib mesylate is an oral multi-kinase inhibitor targeting VEGFR, PDGFRβ, Kit, RET, Raf-1 with strong anti-tumor and anti-angiogenic effects.Formula:C22H19ClF4N4O6SColore e forma:SolidPeso molecolare:578.92Tepotinib hydrochloride(1 : x)
CAS:Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14Formula:C29H29ClN6O2Purezza:99.81%Colore e forma:SolidPeso molecolare:529.04Degrasyn
CAS:Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formula:C19H18BrN3OPurezza:98.32% - 99.98%Colore e forma:SolidPeso molecolare:384.27Ref: TM-T6300
2mg42,00€5mg60,00€10mg92,00€25mg188,00€50mg324,00€100mg505,00€200mg710,00€1mL*10mM (DMSO)66,00€MLN9708 analogues
CAS:MLN2238 inhibits 20S proteasome's β5 site (Ki50=0.93 nM, IC50=3.4 nM), active form of Ixazomib Citrate in solutions/plasma.Formula:C20H23BCl2N2O9Purezza:98.24% - 99.23%Colore e forma:SolidPeso molecolare:517.12Ref: TM-T2016
5mg48,00€10mg63,00€25mg90,00€50mg124,00€100mg203,00€200mg303,00€500mg507,00€1mL*10mM (DMSO)50,00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurezza:98.3% - 99.46%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:407.5E-64
CAS:E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.Formula:C15H27N5O5Purezza:98% - 99.95%Colore e forma:White SolidPeso molecolare:357.41Ref: TM-T6037
2mg37,00€5mg50,00€10mg79,00€25mg140,00€50mg225,00€100mg335,00€500mg790,00€1mL*10mM (DMSO)51,00€Paeonol
CAS:Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.Formula:C9H10O3Purezza:98.55% - 99.56%Colore e forma:White To Beige Crystalline PowderPeso molecolare:166.17SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purezza:98% - 99.97%Colore e forma:Light-Yellow SolidPeso molecolare:392.4AS1842856
CAS:AS1842856 is a Foxo1 inhibitor that blocks the transcriptional activity of Foxo1. AS1842856 has autophagy inhibitory activity. Cost-effective and quality-assured.Formula:C18H22FN3O3Purezza:99.36% - >99.99%Colore e forma:SolidPeso molecolare:347.38Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Formula:C17H17N7Purezza:98.39% - 98.43%Colore e forma:SolidPeso molecolare:319.36Ref: TM-T6945
1mg49,00€2mg67,00€5mg110,00€10mg192,00€25mg429,00€50mg628,00€100mg893,00€500mg1.791,00€1mL*10mM (DMSO)110,00€UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.
Formula:C30H31F3N8O3SPurezza:98.72% - 99.52%Colore e forma:SolidPeso molecolare:640.68Rottlerin
CAS:Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.Formula:C30H28O8Purezza:97.41% - 99.44%Colore e forma:Orange To Brown PowderPeso molecolare:516.54Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formula:C20H15Cl3N2OS·HNO3Purezza:98.66% - 99.65%Colore e forma:SolidPeso molecolare:500.78
