HSV

Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.

<p>Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.</p>

Trifluridine is a fluorinated thymidine analog with antineoplastic and antiviral properties, disrupting DNA and protein synthesis, leading to apoptosis.

<p>Adenosine 5'-monophosphate monohydrate (5'-AMP) , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA.</p>

Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM).

<p>Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.</p>

Docusate sodium (Aerosol OT) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation.

Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.

Famciclovir (BRL 42810) inhibits Herpes virus DNA polymerase by mimicking nucleosides.

<p>Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.</p>

<p>(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of</p>

Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with

Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.

Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.

Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2,

<p>Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.</p>

Penciclovir, a herpesvirus inhibitor, blocks DNA replication in HSV cells by disrupting enzyme activity.

Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

SIBA, a synthetic SAH analog, inhibits SAM-dependent transmethylation and blocks HSV-1 replication.

<p>Cangorinine E-1 (compound 11), a dihydroagarofuran sesquiterpenoid derivative, exhibits weak inhibitory effects on herpes simplex virus type II (HSV) [1].</p>

Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.

<p>Compound 480-68-2, with CAS No. 480-68-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 480-68-2 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>HSV-60mer sodium is a 60 bp double-stranded oligonucleotide that includes viral DNA motifs from the herpes simplex virus 1 (HSV-1) genome. Transfection of HSV-60mer effectively induces IFN-β in a manner dependent on STING, TBK1, and IFN regulatory factor 3 (IRF3).</p>

A-73209: nucleoside analog, oxetanocin family, combats herpes simplex and varicella-zoster viruses effectively.

Compound 20, also known as LANA-DNA-IN-2, is an inhibitor of the interaction between latency-associated nuclear antigen (LANA) and DNA.

Ropidoxuridine (IPdR), a novel oral prodrug, is a halogenated thymidine analogue that may sensitize human tumors.

1-Docosanol, a 22-carbon alcohol, blocks herpes virus entry into cells, aids in healing sores, and relieves pain. Used for herpes simplex.

<p>MPXV I7L protease-IN-1 (compound 11) is an inhibitor of the Monkeypox virus I7L protease, with an IC50 value of 69 nM.</p>

Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.

1,4-Dihydroxynaphthalene A potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses.

<p>Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).</p>

<p>A unique collection of 1040 anti-virus compounds effective for new anti-virus drugs high throughput screening and high content screening;</p>

Peniterphenyl A from deep-sea Penicillium blocks HSV-1/2 entry by targeting glycoprotein D, hindering adsorption and fusion.

9-Carboxymethoxymethylguanine, Aciclovir's main metabolite, is a strong antiviral guanosine analog.

16-epiLatrunculin B, a stereoisomer of the actin polymerization inhibitor latrunculin B, was initially isolated from the Red Sea sponge N. magnifica. At concentrations of 5-10 µg/ml, it disrupts microfilament activity in actin disruption assays and exhibits cytotoxic effects on mouse KA31T and NIH3T3 tumor cells, with GI50 values of 1 and 4 µg/ml, respectively. Furthermore, it shows antiviral activity against herpes simplex type 1 virus, with an ED50 of 1 µg/ml.

3-Deaza-2'-deoxyadenosine inhibits lymphocyte cytolysis at 100 μM with low toxicity; aids in studying adenine N3 in DNA.

This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.

<p>Fiacitabine (NSC-382097) is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively</p>

Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG linker with Vidarabine, an anti-herpes/zoster antiviral.

Pritelivir mesylate hydrate inhibits herpes simplex 1/2 helicase-primase; IC50: 0.02 μM; effective in vitro and in vivo.

N-Lauroylsarcosine is an amphiphilic anionic surfactant from sarcosine, ph-sensitive vesicles and micellar aggregates with antiviral activity against HSV.

LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.

<p>Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-</p>

5-Hydroxymethyldeoxyuridine: anticancer/antiviral; inhibits S180 and Ehrlich cells (ED50=8.5/4 μM) & leukemia lines (IC50=1.7-5.8 μM).

Dalimycin (Oxytetracycline Hydrochloride), from Streptomyces rimosus, blocks tRNA binding, hindering protein synthesis.

Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).

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Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.

OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.

<p>Guanosine (DL-Guanosine) is a purine nucleoside formed from a beta-N9-glycosidic bond between guanine and a ribose ring and is essential for metabolism.</p>

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer

<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, &gt;240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>

Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL

Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.

<p>Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z.</p>

<p>Dynasore, a cell-permeable dynamin inhibitor, blocks GTPase of dynamin 1/2 and Drp1 (IC50: 15 μM) without affecting other small GTPases.</p>

Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM.

2-NP is a STAT1 enhancer.

2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis.

Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.

20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) is a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory.

Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM).

Betulonic acid amide aids liver recovery, reduces fibrosis, and shows potential as an anticancer agent with anticholestatic effects in mice.

<p>Isoborneol (DL-Isoborneol) is a monoterpene alcohol, with neuroprotective and antiviral activities</p>

S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic

FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).

ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).

Oxytetracycline Dihydrate (Terramycin Dihydrate) is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.

<p>Glyceryl monocaprate (2,3-Dihydroxypropyl decanoate) has inhibitory effect on Herpes Simplex Virus (HSV).</p>

<p>Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).</p>

Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir.

<p>Valpromide (Dipropylacetamide) is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders.</p>

Benzyloxycarbonyl valacyclovir is a biochemical.

Tromantadine hydrochloride is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).

WAY 150138 inhibits the herpes simplex virus.

HSV-1/HSV-2-IN-1 inhibits HSV-1, HSV-2, and cowpox virus with EC50 values of 7.6, 7.6, 4, and 12 μM, respectively.

HSV-1/HSV-2-IN-2 is a compound that acts as an inhibitor of HSV-1, HSV-2, and VV, demonstrating antiviral activity with EC50 values of 6.8, 8.9, and 8.9 μM,

SCH-43478 is a non-nucleoside agent of antiviral. It has an effective and selective activity against herpes simplex virus type 2 (HSV-2).

Acyclovir alanine is a pro-drug of Acyclovir. Acyclovir works by decreasing the production of DNA of the virus and it shows very low cytotoxicity.

antiviral drug

Tromantadine is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).

<p>B220, an antiviral agent, inhibits the growth of HSV-1, HSV-2, and human cytomegalovirus (CMV).</p>

Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV).

<p>Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.</p>

<p>CF-1743 is an anti-varicella zoster virus nucleoside and inhibits VZV replication.</p>

Cyclopropavir (Filociclovir; MBX-400) is a broad-spectrum anti-herpes drug effective against CMV and HHV-6/8 (EC50: 0.7-8 μM).

5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.

S-Allylmercapturic Acid (N-Acetyl-S-allyl-L-cysteine) is a metabolite of S-allyl-L-cysteine present in black garlic, with potential anti-gout effects.

Omaciclovir (ABT-091) is a herpesvirus herpesvirus replication inhibitor with antiviral activity that is used in the study of herpesvirus infections.

HSV-TK substrate is a substrate for HSV-TK with antitumor activity. It induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells.

Mer-NF5003F (Stachybotrydial; F 1839M) is a sesquiterpene isolated from Stachybotrys, effective in inhibiting avian myeloblastosis virus (AMV) protease with an IC50 of 7.8 μM. It also inhibits sialyltransferases ST6N, ST3O, and ST3N with IC50 values of 0.61, 6.7, and 10 μg/mL, respectively, and fucosyltransferase with an IC50 of 11.3 μg/mL. Additionally, Mer-NF5003F exhibits in vitro activity against herpes simplex virus HSV-1 (IC50=4.32 μg/mL) and multi-drug-resistant Plasmodium falciparum K1 strain (IC50=0.85 μg/mL).

<p>17,17-Ethylendioxyandrost-5-en-3β-ol, with an EC 50 of 629 μM, acts as an inhibitor of HSV-1. This compound is applicable in research studies focusing on viral infections.</p>

Stearyl gallate is a useful organic compound for research related to life sciences. The catalog number is T65655 and the CAS number is 10361-12-3.

Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models