Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(159 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(50 prodotti)
- EGFR(572 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(241 prodotti)
- Chinasi S6(9 prodotti)
- gsk-3(111 prodotti)
- mTOR(145 prodotti)
Mostrare 2 più sottocategorie
Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
VO-Ohpic trihydrate
CAS:<p>VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.</p>Formula:C12H9N2O8V·3H2O·HPurezza:>99.99%Colore e forma:SolidPeso molecolare:415.2MOTS-c(Human) Acetate(1627580-64-6 free)
<p>MOTS-c(Human) Acetate is a mitochondrial-derived peptide.</p>Formula:C103H156N28O24S2Purezza:100%Colore e forma:SolidPeso molecolare:2234.64A66
CAS:<p>A66 is a specific and effective p110α inhibitor(IC50=32 nM).</p>Formula:C17H23N5O2S2Purezza:99.51% - ≥95%Colore e forma:SolidPeso molecolare:393.53ETP-46321
CAS:<p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>Formula:C20H27N9O3SPurezza:99.8%Colore e forma:SolidPeso molecolare:473.55CP-380736
CAS:CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.Formula:C14H18N2O5Purezza:99.68%Colore e forma:White To Off-White SolidPeso molecolare:294.3Naquotinib
CAS:<p>Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFR</p>Formula:C30H42N8O3Purezza:97.49%Colore e forma:SolidPeso molecolare:562.71Gefitinib hydrochloride
CAS:<p>Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.</p>Formula:C22H25Cl2FN4O3Purezza:99.8%Colore e forma:SolidPeso molecolare:483.36Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formula:C22H26FN3O3Purezza:99.82% - 99.85%Colore e forma:SolidPeso molecolare:399.458CHIR 98024
CAS:<p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>Formula:C20H17Cl2N9O2Purezza:96.74%Colore e forma:SolidPeso molecolare:486.31RLY-2608
CAS:<p>RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.</p>Formula:C29H14ClF5N6O2Purezza:98.62% - 98.7%Colore e forma:SolidPeso molecolare:608.91Canertinib dihydrochloride
CAS:<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Formula:C24H27Cl3FN5O3Purezza:99.13% - >99.99%Colore e forma:SolidPeso molecolare:558.86Almonertinib hydrochloride
CAS:<p>Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.</p>Formula:C30H36ClN7O2Purezza:98.01% - 98.12%Colore e forma:SolidPeso molecolare:562.1Naquotinib mesylate
CAS:<p>Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR</p>Formula:C31H46N8O6SPurezza:98%Colore e forma:SolidPeso molecolare:658.81BMS-690514
CAS:<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Formula:C19H24N6O2Purezza:99.08%Colore e forma:SolidPeso molecolare:368.43Izalontamab
CAS:<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Purezza:95%+ - 95%+Colore e forma:LiquidSerclutamab
CAS:<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Purezza:98%Colore e forma:LiquidFutuximab
CAS:<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Purezza:95% - 95%Colore e forma:LiquidPonezumab
CAS:<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Colore e forma:LiquidImgatuzumab
CAS:<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Colore e forma:LiquidPeso molecolare:145.0 (kDa)Anbenitamab
CAS:<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Colore e forma:LiquidZanidatamab
CAS:<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Colore e forma:LiquidBecotatug
CAS:<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Purezza:95% - 95%Colore e forma:LiquidDepatuxizumab
CAS:<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Purezza:95%Colore e forma:LiquidElgemtumab
CAS:<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Purezza:95%Colore e forma:LiquidZalutumumab
CAS:<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Purezza:95%Colore e forma:LiquidZM323881 hydrochloride
CAS:ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formula:C22H19ClFN3O2Purezza:99.43%Colore e forma:SolidPeso molecolare:411.86lavendustin A
CAS:<p>lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.</p>Formula:C21H19NO6Purezza:98%Colore e forma:Off-White SolidPeso molecolare:381.38Icotinib
CAS:<p>Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.</p>Formula:C22H21N3O4Purezza:99.76% - 99.94%Colore e forma:SolidPeso molecolare:391.42GSK2292767
CAS:<p>GSK2292767 is a potent and selective PI3Kδ inhibitor.</p>Formula:C24H28N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:512.58IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formula:C22H17N3O4Colore e forma:SolidPeso molecolare:387.391-Azakenpaullone
CAS:<p>1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.</p>Formula:C15H10BrN3OPurezza:99.73%Colore e forma:Tan SolidPeso molecolare:328.16TAK-285
CAS:<p>TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.</p>Formula:C26H25ClF3N5O3Purezza:99.73%Colore e forma:SolidPeso molecolare:547.96Icotinib Hydrochloride
CAS:<p>Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.</p>Formula:C22H22ClN3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:427.88CNX-1351
CAS:<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Formula:C30H35N7O3SPurezza:99.66% - 99.83%Colore e forma:SolidPeso molecolare:573.71PI5P4Ks-IN-1
CAS:<p>PI5P4Ks-IN-1 (compound 7) is an active compound which engages PI5P4Kγ[1].</p>Formula:C20H17N3SColore e forma:SolidPeso molecolare:331.43PI3K/mTOR Inhibitor-4
CAS:<p>Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.</p>Formula:C27H22FN3O6SColore e forma:SolidPeso molecolare:535.543F8
CAS:<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formula:C15H14N2O4Purezza:98.14% - 98.25%Colore e forma:SolidPeso molecolare:286.28PIKfyve-IN-2
CAS:<p>PIKfyve-IN-2 is a potent inhibitor of the PIKfyve kinase, with potential applications in cancer and autoimmune disorder research [1].</p>Formula:C22H22N8OColore e forma:SolidPeso molecolare:414.46NSC114126
CAS:<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formula:C22H20O4Colore e forma:SolidPeso molecolare:348.39EGFR-IN-50
CAS:<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Formula:C24H26BrN3O4S2Colore e forma:SolidPeso molecolare:564.51AG-183
CAS:<p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>Formula:C13H8N4O3Colore e forma:Brown SolidPeso molecolare:268.23MRT80
CAS:<p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>Formula:C15H15N5OPurezza:98%Colore e forma:SolidPeso molecolare:281.31PI3Kγ inhibitor 4
CAS:<p>PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM).</p>Formula:C20H24N4O4SColore e forma:SolidPeso molecolare:416.49PI3Kδ/γ-IN-2
CAS:<p>PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy</p>Formula:C25H21ClN8OColore e forma:SolidPeso molecolare:484.94DNA-PK-IN-3
CAS:<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Formula:C19H19N9OColore e forma:SolidPeso molecolare:389.41PI-540
CAS:<p>PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).</p>Formula:C22H27N5O2SColore e forma:SolidPeso molecolare:425.55GNE-293
CAS:<p>GNE-293 is a potent and selective PI3Kδ inhibitor.</p>Formula:C28H36N8O4SPurezza:98%Colore e forma:SolidPeso molecolare:580.7NSC81111
CAS:<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Formula:C19H16O4Colore e forma:SolidPeso molecolare:308.33MIPS-9922
CAS:<p>MIPS-9922: potent PI3Kβ inhibitor; prevents αIIbβ3 activation, platelet adhesion, and ADP-triggered aggregation.</p>Formula:C28H31F2N9O2Purezza:98%Colore e forma:SolidPeso molecolare:563.6ZDWX-25
CAS:<p>ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>Formula:C17H15N3O3Colore e forma:SolidPeso molecolare:309.32DNA-PK-IN-1
CAS:<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Formula:C23H26N8O2Colore e forma:SolidPeso molecolare:446.5EGFR-IN-67
CAS:<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formula:C18H17N3SColore e forma:SolidPeso molecolare:307.41PI3K/mTOR Inhibitor-9
CAS:<p>PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).</p>Formula:C23H27N7O2Colore e forma:SolidPeso molecolare:433.51MS 154N
CAS:<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formula:C47H56ClFN8O8Colore e forma:SolidPeso molecolare:915.45EGFR-IN-2
CAS:<p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>Formula:C26H33N9O3SPurezza:98.52% - 99.79%Colore e forma:SolidPeso molecolare:551.66TCS 2002
CAS:<p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>Formula:C18H14N2O3SColore e forma:SolidPeso molecolare:338.38PI3K/mTOR Inhibitor-3
CAS:<p>PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.</p>Formula:C22H23N5OColore e forma:SolidPeso molecolare:373.45PI3K-IN-38
CAS:<p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>Formula:C20H24N6O2Purezza:99.89%Colore e forma:SolidPeso molecolare:380.44PI3Kδ/γ-IN-1
CAS:<p>PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.</p>Formula:C25H28N6O4SColore e forma:SolidPeso molecolare:508.59EGFR-IN-5
CAS:<p>EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.</p>Formula:C31H38FN9OPurezza:98.17%Colore e forma:SolidPeso molecolare:571.69PI3-Kinase α Inhibitor 2
CAS:<p>Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and</p>Formula:C16H15N3O2SColore e forma:SolidPeso molecolare:313.37EGFR/C797S-IN-1
CAS:<p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>Formula:C28H30N4O3Colore e forma:SolidPeso molecolare:470.56EGFR-IN-53
CAS:<p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>Formula:C14H13N3O2SColore e forma:SolidPeso molecolare:287.34PI3K/mTOR Inhibitor-8
CAS:<p>PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.</p>Formula:C23H22N8O4SColore e forma:SolidPeso molecolare:506.54PI3K/mTOR Inhibitor-13
CAS:<p>PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.</p>Formula:C20H13F2N5O3SColore e forma:SolidPeso molecolare:441.41PI3Ka-IN-5
CAS:<p>PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .</p>Formula:C30H35N9O5Colore e forma:SolidPeso molecolare:601.66EGFR-IN-21
CAS:<p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>Formula:C36H44BrN10O2PColore e forma:SolidPeso molecolare:759.68EGFR/HER2-IN-2
CAS:<p>EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).</p>Formula:C26H23N5O3Colore e forma:SolidPeso molecolare:453.49JBJ-09-063 hydrochloride
<p>JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.</p>Formula:C31H30ClFN4O3SColore e forma:SolidPeso molecolare:593.11EGFR-IN-25
CAS:<p>EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.</p>Formula:C34H43N9O2Colore e forma:SolidPeso molecolare:609.76EGFR-IN-54
CAS:<p>EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.</p>Formula:C17H14N4O4S3Colore e forma:SolidPeso molecolare:434.51BRD1652
CAS:<p>BRD1652 is a highly selective and potent GSK3 inhibitor.</p>Formula:C20H20F3N3OPurezza:98%Colore e forma:SolidPeso molecolare:375.39EGFR-IN-69
CAS:<p>EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.</p>Formula:C31H37Cl2N7O3SColore e forma:SolidPeso molecolare:658.64EGFR-IN-31
CAS:<p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>Formula:C32H36FN7O2Colore e forma:SolidPeso molecolare:569.67DNA-PK-IN-7
CAS:<p>DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).</p>Formula:C19H21N9O2Colore e forma:SolidPeso molecolare:407.43NVP-BBD130
CAS:<p>NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.</p>Formula:C28H21N5OColore e forma:SolidPeso molecolare:443.5PI3K-IN-2
CAS:<p>PI3K-IN-2 inhibits PI3Kβ/δ (IC50: 7.1, 8.6 nM) with greater selectivity over PI3Kσ/γ (IC50: 13, 190 nM) and is orally active.</p>Formula:C28H29F2N3O5Colore e forma:SolidPeso molecolare:525.54EGFR-IN-49
CAS:<p>EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.</p>Formula:C22H15N5O2SColore e forma:SolidPeso molecolare:413.45EGFR-IN-55
CAS:<p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>Formula:C25H25Cl2N7O2Colore e forma:SolidPeso molecolare:526.42Leniolisib phosphate
CAS:<p>Leniolisib phosphate is an effective PI3K inhibitor.</p>Formula:C21H28F3N6O6PColore e forma:SolidPeso molecolare:548.45Nazartinib mesylate
CAS:<p>Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).</p>Formula:C27H35ClN6O5SPurezza:98%Colore e forma:SolidPeso molecolare:591.12DNA-PK-IN-4
CAS:<p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>Formula:C20H24N6O3Colore e forma:SolidPeso molecolare:396.44EGFR/HER2-IN-9
CAS:<p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>Formula:C25H25ClFN5O4Colore e forma:SolidPeso molecolare:513.95Lavendustin C6
CAS:<p>Lavendustin C6 is a effective tyrosine kinase inhibitor.</p>Formula:C20H25NO5Colore e forma:SolidPeso molecolare:359.42PI3Kγ inhibitor 1
CAS:<p>PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.</p>Formula:C32H26N8O2SPurezza:98%Colore e forma:SolidPeso molecolare:586.67BAY 2476568
CAS:<p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).</p>Formula:C24H27FN4O4Colore e forma:SolidPeso molecolare:454.49PKI-179
CAS:<p>PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.</p>Formula:C25H28N8O3Colore e forma:SolidPeso molecolare:488.54EGFR-IN-28
CAS:<p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>Formula:C31H39BrN10O3SColore e forma:SolidPeso molecolare:711.68SIKs-IN-1
CAS:<p>SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2</p>Formula:C27H31F2N7OColore e forma:SolidPeso molecolare:507.58PI3K-IN-36
CAS:<p>PI3K-IN-36 is a potent inhibitor of PI3K, suitable for research applications in follicular lymphoma (FL).</p>Formula:C30H36F2N8OColore e forma:SolidPeso molecolare:562.66PI3Kγ inhibitor 6
CAS:<p>PI3Kγ Inhibitor 6, a specific inhibitor of PI3Kγ, is utilized in the study of inflammatory and autoimmune diseases.</p>Formula:C16H11NO5SColore e forma:SolidPeso molecolare:329.33PKI-179 hydrochloride
CAS:<p>PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.</p>Formula:C25H29ClN8O3Colore e forma:SolidPeso molecolare:525PI3K-IN-28
CAS:<p>PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.</p>Formula:C26H16F9N3O3S2Colore e forma:SolidPeso molecolare:653.54DNA-PK-IN-5
CAS:DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.Formula:C21H22N8O2Colore e forma:SolidPeso molecolare:418.45CAY10717
CAS:<p>CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.</p>Formula:C29H25F3N6O3Colore e forma:SolidPeso molecolare:562.54UNC-CA359
CAS:<p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>Formula:C18H14ClN3O2Colore e forma:SolidPeso molecolare:339.78EGFR-IN-75
<p>EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.</p>Formula:C10H6N6S2Colore e forma:SolidPeso molecolare:274.32PI3Kα-IN-4
CAS:<p>PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].</p>Formula:C25H23ClFN5O5SColore e forma:SolidPeso molecolare:560(E/Z)-AG490
CAS:<p>(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.</p>Formula:C17H14N2O3Colore e forma:SolidPeso molecolare:294.3PD 173955-Analog1
CAS:<p>PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.</p>Formula:C21H14Cl2N4O3Colore e forma:SolidPeso molecolare:441.27
