Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(159 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(50 prodotti)
- EGFR(572 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(241 prodotti)
- Chinasi S6(9 prodotti)
- gsk-3(111 prodotti)
- mTOR(145 prodotti)
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Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"
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EGFR/HER2-IN-3
CAS:<p>EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.</p>Formula:C26H23N5O3Colore e forma:SolidPeso molecolare:453.49eCF-309
CAS:<p>eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.</p>Formula:C18H21N7O3Colore e forma:SolidPeso molecolare:383.4PDZ1i
CAS:<p>PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.</p>Formula:C28H26N8O4Colore e forma:SolidPeso molecolare:538.56BIBX 1382 Dihydrochloride
CAS:<p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>Formula:C18H21Cl3FN7Colore e forma:SolidPeso molecolare:460.76LDC0496
CAS:<p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>Formula:C32H35N5O3Colore e forma:SolidPeso molecolare:537.65PfGSK3/PfPK6-IN-2
CAS:<p>PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.</p>Formula:C24H25Cl2N5OSColore e forma:SolidPeso molecolare:502.46EGFR-IN-63
CAS:<p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>Formula:C20H12BrN5SColore e forma:SolidPeso molecolare:434.31PI3Kδ-IN-3
CAS:PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.Formula:C28H24N6O3Purezza:99.8%Colore e forma:SolidPeso molecolare:492.53EMI48
CAS:<p>EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].</p>Formula:C21H20N2O3Colore e forma:SolidPeso molecolare:348.4OXA-01
CAS:<p>OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.</p>Formula:C21H20ClN5O2Colore e forma:SolidPeso molecolare:409.87CC260
CAS:<p>CC260 selectively inhibits PI5P4Kα/β (Ki: 40/30 nM), with minimal effect on Plk1/RSK2, useful for metabolic, diabetes, and cancer studies.</p>Formula:C24H29Cl2N5O2Colore e forma:SolidPeso molecolare:490.43AS2541019
CAS:<p>AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.</p>Formula:C26H33F2N7O3Colore e forma:SolidPeso molecolare:529.58CHMFL-PI4K-127
CAS:<p>CHMFL-PI4K-127 (15g) selectively inhibits PfPI4K (IC50=0.9 nM), potent against Plasmodium 3D7 (EC50=25.1 nM), with oral anti-malaria activity.</p>Formula:C18H15ClN4O3SColore e forma:SolidPeso molecolare:402.85EMI56
CAS:<p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>Formula:C21H20N2O3Colore e forma:SolidPeso molecolare:348.4EGFR-IN-39
CAS:<p>EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.</p>Formula:C24H25ClN6O3Colore e forma:SolidPeso molecolare:480.95SIC-19
CAS:<p>SIC-19, a SIK2 inhibitor, functions by promoting the degradation of SIK2 protein via the ubiquitination pathway. It inhibits the growth of cancer cells and sensitizes cells, ovarian cancer organoids, and xenograft models to PARP inhibitors (such as Olaparib).</p>Formula:C29H26N4O5S2Colore e forma:SolidPeso molecolare:574.67JR-AB2-011
CAS:<p>JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.</p>Formula:C17H14Cl2FN3OSPurezza:98.33% - 98.33%Colore e forma:SolidPeso molecolare:398.28EGFR mutant-IN-2
CAS:<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Formula:C27H27F3N6O2SColore e forma:SolidPeso molecolare:556.6P-2281
CAS:<p>P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell</p>Formula:C9H8ClN3OPurezza:99.95%Colore e forma:SolidPeso molecolare:209.63PI3K-IN-6
CAS:PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).Formula:C17H14Cl2FN9OPurezza:98%Colore e forma:SolidPeso molecolare:450.26Nimotuzumab
CAS:<p>Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).</p>Purezza:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Colore e forma:LiquidMutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formula:C29H35FN8O3Purezza:98%Colore e forma:SolidPeso molecolare:562.64Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formula:C13H8N4OPurezza:99.14%Colore e forma:SolidPeso molecolare:236.23PI3K-IN-9
CAS:<p>PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).</p>Formula:C19H23N7OPurezza:98%Colore e forma:SolidPeso molecolare:365.43PI3K-IN-10
CAS:<p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>Formula:C23H19ClN6OPurezza:98%Colore e forma:SolidPeso molecolare:430.89PI3Kα-IN-13
CAS:<p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>Formula:C21H19N5O3Purezza:98%Colore e forma:SolidPeso molecolare:389.41PI4KIII β inhibitor 3
CAS:PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).Formula:C22H22N8OSPurezza:98%Colore e forma:SolidPeso molecolare:446.53FT-1518
CAS:FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Formula:C20H26N8OPurezza:98.34% - 98.80%Colore e forma:SolidPeso molecolare:394.47AZD3458
CAS:<p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).</p>Formula:C20H23N3O4S2Colore e forma:SolidPeso molecolare:433.54EGFR-IN-16
CAS:<p>EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.</p>Formula:C16H11NO3Purezza:98%Colore e forma:SolidPeso molecolare:265.26NU-7163
CAS:<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Formula:C18H17NO3Purezza:98%Colore e forma:SolidPeso molecolare:295.33EGA
CAS:EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Formula:C16H16BrN3OPurezza:98% - 99.6%Colore e forma:SolidPeso molecolare:346.22DS21360717
CAS:<p>DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.</p>Formula:C21H23N7OPurezza:98%Colore e forma:SolidPeso molecolare:389.45BKI-1369
CAS:<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formula:C23H27N7OColore e forma:SolidPeso molecolare:417.51WR23
CAS:<p>WR23 is a piperidinylquinoxaline derivative and a phosphoinositide 3-kinase α (PI3Kα) inhibitor.</p>Formula:C19H18BrN3O3SPurezza:98%Colore e forma:SolidPeso molecolare:448.33LTURM-36
CAS:<p>LTURM-36 is a novel inhibitor of PI 3-kinase delta.</p>Formula:C22H18N2O3Purezza:98%Colore e forma:SolidPeso molecolare:358.39CAL-130 Hydrochloride
CAS:<p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H23ClN8OColore e forma:SolidPeso molecolare:462.94Limertinib
CAS:<p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>Formula:C29H32ClN7O2Purezza:97.44%Colore e forma:SolidPeso molecolare:546.06EAI001
CAS:<p>EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.</p>Formula:C19H15N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:349.41mTOR inhibitor-2
CAS:<p>mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).</p>Formula:C23H21N7OPurezza:98%Colore e forma:SolidPeso molecolare:411.46(E/Z)-CP-724714
CAS:<p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>Formula:C27H27N5O3Purezza:98%Colore e forma:SolidPeso molecolare:469.54GW 583340 dihydrochloride
CAS:<p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>Formula:C28H27Cl3FN5O3S2Purezza:98.80%Colore e forma:SolidPeso molecolare:671.03Nemiralisib
CAS:<p>Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.</p>Formula:C26H28N6OPurezza:99.91%Colore e forma:SolidPeso molecolare:440.54CAL-130
CAS:CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:426.47Tarlox-TKI
CAS:Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formula:C19H18BrClN6OPurezza:97.03%Colore e forma:SolidPeso molecolare:461.74RTC-5
CAS:<p>RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.</p>Formula:C24H22ClF3N2O3SPurezza:98.14%Colore e forma:SolidPeso molecolare:510.96Epertinib
CAS:<p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>Formula:C30H27ClFN5O3Purezza:98%Colore e forma:SolidPeso molecolare:560.02FD2056
CAS:<p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>Formula:C23H17ClN6O2SPurezza:98%Colore e forma:SolidPeso molecolare:476.94EGFR-IN-89
CAS:<p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>Formula:C26H31FN8O2SPurezza:98%Colore e forma:SolidPeso molecolare:538.64Antiproliferative agent-34
CAS:<p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>Formula:C27H27N7O5Purezza:98%Colore e forma:SolidPeso molecolare:529.55PIMPC
CAS:<p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>Formula:C21H19N5OPurezza:98%Colore e forma:SolidPeso molecolare:357.41PI3Kγ inhibitor 7
CAS:<p>PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].</p>Formula:C31H25N9O2Purezza:98%Colore e forma:SolidPeso molecolare:555.59EGFR-IN-73
CAS:<p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>Formula:C19H17ClFN3O4Purezza:98%Colore e forma:SolidPeso molecolare:405.81Selatinib
CAS:<p>Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.</p>Formula:C29H26ClFN4O3SPurezza:98.00%Colore e forma:SolidPeso molecolare:565.06CGP52411
CAS:<p>CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).</p>Formula:C20H15N3O2Purezza:99.78%Colore e forma:SolidPeso molecolare:329.35GLPG3970
CAS:GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.Formula:C25H27F3N4O4Purezza:99.60% - >99.99%Colore e forma:SolidPeso molecolare:504.5GSK-3β inhibitor 12
CAS:<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Formula:C14H13N3OSPurezza:98.58%Colore e forma:SolidPeso molecolare:271.34BRD0209
CAS:<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formula:C22H25N3OPurezza:99.92%Colore e forma:SolidPeso molecolare:347.45AMPK activator 4
CAS:<p>Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.</p>Formula:C24H21ClN2O3Purezza:99.46% - 99.65%Colore e forma:SolidPeso molecolare:420.89PI3Kα/mTOR-IN-1
CAS:<p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>Formula:C16H18N6OPurezza:99.89%Colore e forma:SolidPeso molecolare:310.35Mutated EGFR-IN-3
CAS:<p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>Formula:C31H29FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:508.59PI3Kdelta inhibitor 1
CAS:<p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>Formula:C27H38N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:558.69PI3K/mTOR Inhibitor-2
CAS:<p>Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.</p>Formula:C20H13ClF2N4O4SPurezza:96.16%Colore e forma:SolidPeso molecolare:478.86Aloisine B
CAS:<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Formula:C15H14ClN3Purezza:95.15%Colore e forma:SolidPeso molecolare:271.74GSK3-IN-2
CAS:<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Formula:C17H19N3OSPurezza:98.8%Colore e forma:SolidPeso molecolare:313.42AM-0687
CAS:<p>AM-0687: Strong PI3Kδ blocker; pAKT IC50=0.7nM, u(pAKT) IC50=4.6nM; Rat IgG ED50=0.026mg/kg, IgM ED50=0.016mg/kg; Clu=2.3L/hr/kg.</p>Formula:C23H19FN8OPurezza:98%Colore e forma:SolidPeso molecolare:442.45Tyrphostin 51
CAS:<p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>Formula:C13H8N4O3Purezza:98%Colore e forma:SolidPeso molecolare:268.23SDZ281-977
CAS:<p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>Formula:C18H20O5Purezza:99.64%Colore e forma:SolidPeso molecolare:316.3518BIOder
CAS:18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.Formula:C9H7ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:210.62JNJ28871063 hydrochloride
CAS:<p>ErbB receptor family inhibitor</p>Formula:C24H28Cl2N6O3Purezza:98%Colore e forma:SolidPeso molecolare:519.42NVS-PI3-4
CAS:<p>NVS-PI3-4: A selective PI3Kγ inhibitor for research in allergies, inflammation, and cancer.</p>Formula:C20H26N4O3SColore e forma:SolidPeso molecolare:402.51DBPR112
CAS:<p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>Formula:C32H31N5O3Purezza:99.25%Colore e forma:SolidPeso molecolare:533.62TC-G 24
CAS:<p>GSK-3β inhibitor</p>Formula:C15H11ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:330.73(R)-PS210
CAS:(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).Formula:C19H15F3O5Colore e forma:SolidPeso molecolare:380.31EGFR-IN-64
CAS:<p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>Formula:C20H21N3O3Colore e forma:SolidPeso molecolare:351.4BRD3731
CAS:<p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>Formula:C24H31N3OColore e forma:SolidPeso molecolare:377.52JBJ-04-125-02
CAS:<p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>Formula:C29H26FN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:543.61RV-1729
CAS:<p>RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.</p>Formula:C39H39ClN8O5Colore e forma:SolidPeso molecolare:735.23TGX-155
CAS:<p>TGX-155 is a selective PI3K inhibitor.</p>Formula:C20H19FN2O3Purezza:98%Colore e forma:SolidPeso molecolare:354.37EGFR-IN-68
CAS:<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formula:C24H22N2OColore e forma:SolidPeso molecolare:354.44NVP-CLR457
CAS:<p>NVP-CLR457 is an oral pan-class I PI3K inhibitor with dose-dependent antitumor activity.</p>Formula:C18H20F3N7O4Colore e forma:SolidPeso molecolare:455.39PP30
CAS:<p>PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.</p>Formula:C18H19N7OSPurezza:98%Colore e forma:SolidPeso molecolare:381.453,5-dimethyl PIT-1
CAS:<p>PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as</p>Formula:C16H15N3O4SColore e forma:SolidPeso molecolare:345.37VP3.15
CAS:<p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>Formula:C20H22N4OSPurezza:98%Colore e forma:SolidPeso molecolare:366.48Cazpaullone
CAS:<p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>Formula:C16H10N4OColore e forma:SolidPeso molecolare:274.28Gefitinib N-oxide
CAS:<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.</p>Formula:C22H24ClFN4O4Purezza:98%Colore e forma:SolidPeso molecolare:462.9AZ2
CAS:<p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>Formula:C20H23N3O2SPurezza:99.25%Colore e forma:SolidPeso molecolare:369.48PI3KD/V-IN-01
CAS:<p>PI3KD/V-IN-01 is a potent ATP-competitive PI3Kδ/Vps34 dual inhibitor.</p>Formula:C21H24ClN5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:494.03MS 39
CAS:<p>MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.</p>Formula:C55H71ClFN9O7SColore e forma:SolidPeso molecolare:1056.72CHMFL-PI3KD-317
CAS:<p>CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.</p>Formula:C21H24ClN5O3S2Purezza:99.16%Colore e forma:SolidPeso molecolare:494.03(S)-PI3Kα-IN-4
CAS:<p>(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM.</p>Formula:C25H23ClFN5O5SColore e forma:SolidPeso molecolare:560(R)-(-)-Rolipram
CAS:(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.Formula:C16H21NO3Purezza:99.54%Colore e forma:SolidPeso molecolare:275.34ABC1183
CAS:<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Formula:C18H14N4OSPurezza:98.92%Colore e forma:SolidPeso molecolare:334.39A-935142
CAS:<p>A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.</p>Formula:C18H19F3N2O2Purezza:98.97% - 99.91%Colore e forma:SolidPeso molecolare:352.35RS1-PDK1 inhibitor
CAS:<p>RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.</p>Formula:C15H9ClN2O2S3Purezza:98.12%Colore e forma:SolidPeso molecolare:380.89YLF-466D
CAS:<p>YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.</p>Formula:C29H20ClNO3Purezza:97.74%Colore e forma:SolidPeso molecolare:465.93GSK-3β inhibitor 2
CAS:<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Formula:C14H14N4O3SPurezza:99.08%Colore e forma:SolidPeso molecolare:318.35YKL-06-062
CAS:<p>YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.</p>Formula:C31H39N7OPurezza:99.87%Colore e forma:SolidPeso molecolare:525.69Rezivertinib
CAS:<p>Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.</p>Formula:C27H30N6O3Purezza:99.26% - 99.89%Colore e forma:SolidPeso molecolare:486.57CGP77675
CAS:<p>CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and</p>Formula:C26H29N5O2Purezza:99.66%Colore e forma:SolidPeso molecolare:443.54
