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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

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Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • Tyrphostin B44, (+) enantiomer
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    Tyrphostin B44, (+) enantiomer

    CAS:
    Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)
    Formula:C18H16N2O3
    Purezza:97.18%
    Colore e forma:Solid
    Peso molecolare:308.33

    Ref: TM-T22450

  • Sulforaphene
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    Sulforaphene

    CAS:
    Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.
    Formula:C6H9NOS2
    Purezza:97.55% - 99.67%
    Colore e forma:Slightly Yellowish Liquid
    Peso molecolare:175.27

    Ref: TM-TL0016

  • KU-0063794
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    KU-0063794

    CAS:
    <p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>
    Formula:C25H31N5O4
    Purezza:98.21% - >99.99%
    Colore e forma:Solid
    Peso molecolare:465.54

    Ref: TM-T2475

  • TGX-221
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    TGX-221

    CAS:
    <p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>
    Formula:C21H24N4O2
    Purezza:99.68% - >99.99%
    Colore e forma:Solid
    Peso molecolare:364.44

    Ref: TM-T2661

  • Torin 2
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    Torin 2

    CAS:
    <p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>
    Formula:C24H15F3N4O
    Purezza:98.31% - 99.32%
    Colore e forma:Solid
    Peso molecolare:432.4

    Ref: TM-T6100

  • Trastuzumab
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    Trastuzumab

    CAS:
    Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.
    Purezza:97.1% (SDS-PAGE); 99.2% (SEC-HPLC) - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%
    Colore e forma:Liquid
    Peso molecolare:Approximately 145.53 kDa

    Ref: TM-T9912

  • GNE-317
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    GNE-317

    CAS:
    GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
    Formula:C19H22N6O3S
    Purezza:98.42% - 99.54%
    Colore e forma:Solid
    Peso molecolare:414.48

    Ref: TM-T6845

  • Dacomitinib
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    Dacomitinib

    CAS:
    <p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>
    Formula:C24H25ClFN5O2
    Purezza:99.4% - 99.72%
    Colore e forma:Solid
    Peso molecolare:469.94

    Ref: TM-T2483

  • NRC-2694
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    NRC-2694

    CAS:
    NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.
    Formula:C24H26N4O3
    Purezza:99.90%
    Colore e forma:Solid
    Peso molecolare:418.49

    Ref: TM-T16343

  • Autogramin-1
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    Autogramin-1

    CAS:
    <p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>
    Formula:C23H27N5O5S
    Purezza:97.69% - 99.25%
    Colore e forma:Solid
    Peso molecolare:485.56

    Ref: TM-T10413

  • AG-1557 hydrochloride (189290-58-2(free base))
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    AG-1557 hydrochloride (189290-58-2(free base))

    AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
    Formula:C16H15ClIN3O2
    Purezza:98.64%
    Colore e forma:Solid
    Peso molecolare:443.66

    Ref: TM-T4694

  • AEE788
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    AEE788

    CAS:
    <p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>
    Formula:C27H32N6
    Purezza:98% - >99.99%
    Colore e forma:Solid
    Peso molecolare:440.58

    Ref: TM-T2116

  • IM-12
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    IM-12

    CAS:
    <p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>
    Formula:C22H20FN3O2
    Purezza:99.42% - >99.99%
    Colore e forma:Solid
    Peso molecolare:377.41

    Ref: TM-T2261

  • KU-57788
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    KU-57788

    CAS:
    <p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>
    Formula:C25H19NO3S
    Purezza:98% - >99.99%
    Colore e forma:Solid
    Peso molecolare:413.49

    Ref: TM-T6276

  • BI-4020
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    BI-4020

    CAS:
    <p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>
    Formula:C30H38N8O2
    Purezza:97.21% - >99.99%
    Colore e forma:Solid
    Peso molecolare:542.68

    Ref: TM-T10534

  • GS87
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    GS87

    CAS:
    GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.
    Formula:C16H11N5O2S
    Purezza:98.86%
    Colore e forma:Solid
    Peso molecolare:337.36

    Ref: TM-T8605

  • Voxtalisib
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    Voxtalisib

    CAS:
    Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
    Formula:C13H14N6O
    Purezza:98.21% - 99.69%
    Colore e forma:Solid
    Peso molecolare:270.29

    Ref: TM-T7014

  • Mutant EGFR inhibitor
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    Mutant EGFR inhibitor

    CAS:
    <p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>
    Formula:C27H30ClN7O2
    Purezza:98% - 99.75%
    Colore e forma:Solid
    Peso molecolare:520.03

    Ref: TM-T2705

  • (S)-Sunvozertinib
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    (S)-Sunvozertinib

    CAS:
    (S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
    Formula:C29H35ClFN7O3
    Purezza:99.64%
    Colore e forma:Solid
    Peso molecolare:584.08

    Ref: TM-T9304

  • BpV(HOpic)
    Targetmol
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    BpV(HOpic)

    CAS:
    BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).
    Formula:C6H4K2NO8V
    Purezza:99.60%
    Colore e forma:Solid
    Peso molecolare:347.24

    Ref: TM-T7953