Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(159 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(50 prodotti)
- EGFR(572 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(241 prodotti)
- Chinasi S6(9 prodotti)
- gsk-3(111 prodotti)
- mTOR(145 prodotti)
Mostrare 2 più sottocategorie
Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"
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Parsaclisib hydrochloride
CAS:Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.Formula:C20H23Cl2FN6O2Purezza:98%Colore e forma:SolidPeso molecolare:469.34Tucatinib
CAS:<p>Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).</p>Formula:C26H24N8O2Purezza:99.05% - 99.96%Colore e forma:SolidPeso molecolare:480.52GSK2636771
CAS:<p>GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and</p>Formula:C22H22F3N3O3Purezza:98.58% - ≥95%Colore e forma:SolidPeso molecolare:433.42ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFormula:C16H11N3O3Purezza:99.8%Colore e forma:SolidPeso molecolare:293.28AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formula:C16H18N2OPurezza:98.12%Colore e forma:SolidPeso molecolare:254.33KU-57788
CAS:<p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>Formula:C25H19NO3SPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:413.49AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Formula:C19H18N4O2Purezza:97.72% - 99.75%Colore e forma:SolidPeso molecolare:334.37Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Formula:C23H14ClF3N6OPurezza:99.81%Colore e forma:SolidPeso molecolare:482.85Torin 2
CAS:<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Formula:C24H15F3N4OPurezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:432.4Dacomitinib
CAS:<p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>Formula:C24H25ClFN5O2Purezza:99.4% - 99.72%Colore e forma:SolidPeso molecolare:469.94Taselisib
CAS:<p>Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.</p>Formula:C24H28N8O2Purezza:99.62% - 99.79%Colore e forma:SolidPeso molecolare:460.53HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formula:C26H28N8OPurezza:98.38% - 99.70%Colore e forma:SolidPeso molecolare:468.55Poziotinib hydrochloride
CAS:<p>Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.</p>Formula:C23H22Cl3FN4O3Purezza:99.69% - 99.81%Colore e forma:SolidPeso molecolare:527.8Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:450.46TAS0728
CAS:<p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>Formula:C26H32N8O3Purezza:97.78%Colore e forma:SolidPeso molecolare:504.58CH5132799
CAS:<p>CH5132799 has been used in trials studying the treatment of Solid Tumors.</p>Formula:C15H19N7O3SPurezza:99.41% - 99.87%Colore e forma:SolidPeso molecolare:377.42Pilaralisib
CAS:<p>Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).</p>Formula:C25H25ClN6O4SPurezza:98.51% - 99.61%Colore e forma:SolidPeso molecolare:541.02KU-0063794
CAS:<p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>Formula:C25H31N5O4Purezza:98.21% - >99.99%Colore e forma:SolidPeso molecolare:465.54Olmutinib
CAS:<p>Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.</p>Formula:C26H26N6O2SPurezza:99.63%Colore e forma:SolidPeso molecolare:486.59TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formula:C6HBr4N3Purezza:98.51% - 99.45%Colore e forma:Off-White SolidPeso molecolare:434.71PIK-75 hydrochloride
CAS:<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Formula:C16H14BrN5O4S·HClPurezza:97.82%Colore e forma:SolidPeso molecolare:488.74Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Formula:C18H16N2O3Purezza:97.18%Colore e forma:SolidPeso molecolare:308.33Rostafuroxin
CAS:<p>Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.</p>Formula:C23H34O4Purezza:99.08% - >99.99%Colore e forma:SolidPeso molecolare:374.51Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Formula:C25H26N6O2Purezza:99.67%Colore e forma:SolidPeso molecolare:442.51GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurezza:98.42% - 99.54%Colore e forma:SolidPeso molecolare:414.48Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formula:C24H25ClFN5O3Purezza:98.56% - 99.9%Colore e forma:Off-White SolidPeso molecolare:485.94Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Formula:C23H27N5O5SPurezza:97.69% - 99.25%Colore e forma:SolidPeso molecolare:485.56Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formula:C29H32N6O8Colore e forma:SolidPeso molecolare:592.6BIO-acetoxime
CAS:<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>Formula:C18H12BrN3O3Purezza:97.15%Colore e forma:SolidPeso molecolare:398.21GSK3i XIII
CAS:<p>GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.</p>Formula:C18H19N5Purezza:98.87%Colore e forma:SolidPeso molecolare:305.38Olmutinib
CAS:Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorFormula:C26H26N6O2SPurezza:99.14%Colore e forma:SolidPeso molecolare:486.59WZ-3146
CAS:<p>WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).</p>Formula:C24H25ClN6O2Purezza:97.15%Colore e forma:SolidPeso molecolare:464.95PKD-IN-1 dihydrochloride (956121-30-5 free base)
CAS:<p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>Formula:C18H21Cl3N4OPurezza:99.5%Colore e forma:SolidPeso molecolare:415.75AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formula:C16H15ClIN3O2Purezza:98.64%Colore e forma:SolidPeso molecolare:443.66IM-12
CAS:<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Formula:C22H20FN3O2Purezza:99.42% - >99.99%Colore e forma:SolidPeso molecolare:377.41Duvelisib
CAS:<p>Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.</p>Formula:C22H17ClN6OPurezza:98.87% - 99.74%Colore e forma:SolidPeso molecolare:416.86AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Formula:C22H24N4O4Purezza:99.79% - 99.95%Colore e forma:SolidPeso molecolare:408.45WHI-P258
CAS:<p>WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.</p>Formula:C16H15N3O2Purezza:99.66% - 99.92%Colore e forma:SolidPeso molecolare:281.31BI-4020
CAS:<p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>Formula:C30H38N8O2Purezza:97.21% - >99.99%Colore e forma:SolidPeso molecolare:542.68GSK-3β inhibitor 10
CAS:<p>GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.</p>Formula:C12H12N2O3SPurezza:98.06%Colore e forma:SolidPeso molecolare:264.3(S)-Sunvozertinib
CAS:<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formula:C29H35ClFN7O3Purezza:99.64%Colore e forma:SolidPeso molecolare:584.08Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Formula:C28H31F3N8O2Purezza:99.87%Colore e forma:SolidPeso molecolare:568.59YKL-06-061
CAS:<p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>Formula:C30H37N7O2Purezza:99.52% - 99.79%Colore e forma:SolidPeso molecolare:527.66Selective PI3Kδ Inhibitor 1
CAS:<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Formula:C23H20FN7OPurezza:97.96%Colore e forma:SolidPeso molecolare:429.45PIK-75
CAS:<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formula:C16H14BrN5O4SPurezza:98.52% - >99.99%Colore e forma:SolidPeso molecolare:452.28NRC-2694 hydrochloride
CAS:<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formula:C24H27ClN4O3Colore e forma:SolidPeso molecolare:454.95PD153035
CAS:<p>PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,</p>Formula:C16H14BrN3O2Purezza:98.47% - 99.29%Colore e forma:SolidPeso molecolare:360.21KI8751
CAS:<p>KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.</p>Formula:C24H18F3N3O4Purezza:99.22% - 99.9%Colore e forma:SolidPeso molecolare:469.41CL-387785
CAS:<p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>Formula:C18H13BrN4OPurezza:99.56% - 99.62%Colore e forma:SolidPeso molecolare:381.23WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purezza:97.93% - 99.94%Colore e forma:SolidPeso molecolare:569.58
