PI3K
Gli inibitori di PI3K sono composti che bloccano l'attività delle fosfoinositide 3-chinasi (PI3K), una famiglia di enzimi coinvolti in una vasta gamma di processi cellulari, tra cui crescita, proliferazione, sopravvivenza e metabolismo. La via PI3K/Akt/mTOR è spesso disregolata nel cancro, rendendo PI3K un obiettivo chiave per la terapia oncologica. Gli inibitori di PI3K sono strumenti critici per studiare la trasduzione del segnale, la biologia del cancro e lo sviluppo di terapie mirate. Presso CymitQuimica, offriamo una varietà di inibitori di PI3K per supportare la tua ricerca nella segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 236 prodotti di "PI3K"
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CAL-130 Racemate
CAS:CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:426.47PI3Kδ-IN-1
CAS:PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).Formula:C22H20F3N7O2Purezza:99.85%Colore e forma:SolidPeso molecolare:471.44MIPS-21335
CAS:<p>MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with</p>Formula:C24H21N7O5Purezza:98%Colore e forma:SolidPeso molecolare:487.47LAS191954
CAS:LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).Formula:C20H15N9OPurezza:98%Colore e forma:SolidPeso molecolare:397.39SAR-260301
CAS:<p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>Formula:C19H22N4O3Purezza:99.74%Colore e forma:SolidPeso molecolare:354.4Zandelisib
CAS:Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.Formula:C31H38F2N8OPurezza:99.88%Colore e forma:SolidPeso molecolare:576.68GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formula:C24H32N6O3Purezza:96.00% - 98.17%Colore e forma:SolidPeso molecolare:452.55GSK-F1
CAS:GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.Formula:C27H18F5N5O4SPurezza:97.03%Colore e forma:SolidPeso molecolare:603.52PF-04979064
CAS:<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Formula:C24H26N6O3Purezza:98.20% - ≥98%Colore e forma:SolidPeso molecolare:446.5VVD-699
CAS:<p>VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.</p>Formula:C25H30ClFN2O6S2Colore e forma:SolidPeso molecolare:573.097PI3Kδ-IN-23
CAS:PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.Formula:C30H30N6O5Colore e forma:SolidPeso molecolare:554.596PI3kδ inhibitor 1
CAS:<p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>Formula:C28H33FN6O2Purezza:98%Colore e forma:SolidPeso molecolare:504.60UNI418
CAS:<p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>Formula:C22H16N6Colore e forma:SolidPeso molecolare:364.40Sonolisib
CAS:Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).Formula:C29H35NO8Purezza:98%Colore e forma:SolidPeso molecolare:525.59Duvelisib (R enantiomer)
CAS:Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.Formula:C22H17ClN6OPurezza:98%Colore e forma:SolidPeso molecolare:416.86PI3Kδ-IN-13
CAS:<p>PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including</p>Formula:C27H39N7O4S2Colore e forma:SolidPeso molecolare:589.77
