PI3K
Gli inibitori di PI3K sono composti che bloccano l'attività delle fosfoinositide 3-chinasi (PI3K), una famiglia di enzimi coinvolti in una vasta gamma di processi cellulari, tra cui crescita, proliferazione, sopravvivenza e metabolismo. La via PI3K/Akt/mTOR è spesso disregolata nel cancro, rendendo PI3K un obiettivo chiave per la terapia oncologica. Gli inibitori di PI3K sono strumenti critici per studiare la trasduzione del segnale, la biologia del cancro e lo sviluppo di terapie mirate. Presso CymitQuimica, offriamo una varietà di inibitori di PI3K per supportare la tua ricerca nella segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 237 prodotti per "PI3K".
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PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formula:C21H19ClN4O4Colore e forma:SolidPeso molecolare:426.853740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Formula:C143H226N43O41PS3Purezza:99.92%Colore e forma:SoildPeso molecolare:3330.79IHMT-PI3Kδ-372 S-isomer
CAS:IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Formula:C26H23F2N7O2Purezza:99.97%Colore e forma:White SolidPeso molecolare:503.5Ref: TM-T60196
1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)294,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€PROTAC PI3K/110β degrader-1
CAS:PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Formula:C51H65N9O9SColore e forma:SolidPeso molecolare:980.18D-106669
CAS:D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Formula:C17H18N6OColore e forma:SolidPeso molecolare:322.36GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formula:C29H37FN6O4SPurezza:99.8%Colore e forma:White SolidPeso molecolare:584.71Ref: TM-T39573
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta1mg155,00€5mg375,00€PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formula:C20H15Cl2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:444.27PI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Formula:C50H46F4N8O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1027.07PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Formula:C20H25F3N8O4Purezza:98.01%Colore e forma:White SolidPeso molecolare:498.46PIP4K-IN-a131
CAS:PIP4K-IN-a131 is a PIP4K inhibitor with antiproliferative effects.Formula:C20H13N3Colore e forma:Yellow SolidPeso molecolare:295.35TGX-221
CAS:TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.Formula:C21H24N4O2Purezza:99.60% - >99.99%Colore e forma:White SolidPeso molecolare:364.44Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purezza:99.66% - 99.96%Colore e forma:White SolidPeso molecolare:696.82Ref: TM-T5S1982
1mg34,00€5mg73,00€10mg101,00€1mL*10mM (DMSO)102,00€25mg167,00€50mg240,00€100mg355,00€500mg845,00€GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Formula:C18H11N3O2SPurezza:99.3% - ≥95%Colore e forma:White SolidPeso molecolare:333.36PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Formula:C16H14BrN5O4S·HClPurezza:97.82%Colore e forma:SolidPeso molecolare:488.74Glaucocalyxin A
CAS:Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.Formula:C20H28O4Purezza:99.55% - 99.80%Colore e forma:White SolidPeso molecolare:332.43PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Formula:C22H24N2O3Purezza:98.92%Colore e forma:SolidPeso molecolare:364.44Ref: TM-T28416
1mg38,00€2mg54,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg241,00€50mg349,00€100mg482,00€200mg662,00€Esculetin
CAS:Esculetin: a coumarin from plants with anti-edema, anti-inflammatory, anti-tumor properties; inhibits LOs.Formula:C9H6O4Purezza:98.03% - 99.76%Colore e forma:Yellow SolidPeso molecolare:178.14Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.Formula:C16H17N3O2Purezza:97.30% - 98.82%Colore e forma:SolidPeso molecolare:283.33NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Formula:C18H20N8O2Purezza:97.79%Colore e forma:White SolidPeso molecolare:380.4Ref: TM-T22377
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta1mg34,00€1mL*10mM (DMSO)89,00€5mg92,00€YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Formula:C20H20BrNO2Purezza:99.65%Colore e forma:SolidPeso molecolare:386.28Ref: TM-T13376
1mg46,00€2mg58,00€1mL*10mM (DMSO)92,00€5mg95,00€10mg137,00€25mg260,00€50mg386,00€100mg560,00€500mg1.153,00€
