PI3K
Gli inibitori di PI3K sono composti che bloccano l'attività delle fosfoinositide 3-chinasi (PI3K), una famiglia di enzimi coinvolti in una vasta gamma di processi cellulari, tra cui crescita, proliferazione, sopravvivenza e metabolismo. La via PI3K/Akt/mTOR è spesso disregolata nel cancro, rendendo PI3K un obiettivo chiave per la terapia oncologica. Gli inibitori di PI3K sono strumenti critici per studiare la trasduzione del segnale, la biologia del cancro e lo sviluppo di terapie mirate. Presso CymitQuimica, offriamo una varietà di inibitori di PI3K per supportare la tua ricerca nella segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 236 prodotti di "PI3K"
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GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.44Sapanisertib
CAS:<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formula:C15H15N7OPurezza:99.19% - >99.99%Colore e forma:SolidPeso molecolare:309.33PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Formula:C18H13FN6OSPurezza:99.85%Colore e forma:SolidPeso molecolare:380.4NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formula:C20H14F3N3SPurezza:99.84% - 99.9%Colore e forma:SolidPeso molecolare:385.41Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Formula:C23H24N8O4SPurezza:98.27% - 99.87%Colore e forma:SolidPeso molecolare:508.55Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Formula:C21H24NNaO8SPurezza:98% - 99.37%Colore e forma:SolidPeso molecolare:473.47TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFormula:C13H17N5O3SPurezza:98.14%Colore e forma:SolidPeso molecolare:323.37Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Formula:C22H18FN7OPurezza:98% - 99.39%Colore e forma:SolidPeso molecolare:415.42BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purezza:95.74% - 99.78%Colore e forma:SolidPeso molecolare:534.53PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Formula:C27H31FN6OSPurezza:99.84% - ≥95%Colore e forma:SolidPeso molecolare:506.64Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formula:C23H24O8Purezza:95.84% - 99.77%Colore e forma:White SolidPeso molecolare:428.43AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Formula:C14H8FNO4SPurezza:99.06% - 99.09%Colore e forma:SolidPeso molecolare:305.28BEBT-908
CAS:BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Formula:C23H25N9O3SPurezza:99.67%Colore e forma:SolidPeso molecolare:507.57Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purezza:96.66% - 99.93%Colore e forma:SolidPeso molecolare:332.39Eganelisib
CAS:Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)Formula:C30H24N8O2Purezza:98.92% - 99.28%Colore e forma:SolidPeso molecolare:528.56Copanlisib
CAS:<p>Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.</p>Formula:C23H28N8O4Purezza:99% - 99.88%Colore e forma:SolidPeso molecolare:480.52Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Formula:C17H17N7Purezza:98.39% - 98.43%Colore e forma:SolidPeso molecolare:319.36GDC0084
CAS:<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formula:C18H22N8O2Purezza:99.72% - 99.87%Colore e forma:SolidPeso molecolare:382.42Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:450.46BQR-695
CAS:<p>BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.</p>Formula:C19H20N4O3Purezza:98.91% - 99.69%Colore e forma:SolidPeso molecolare:352.39
