PI3K
Gli inibitori di PI3K sono composti che bloccano l'attività delle fosfoinositide 3-chinasi (PI3K), una famiglia di enzimi coinvolti in una vasta gamma di processi cellulari, tra cui crescita, proliferazione, sopravvivenza e metabolismo. La via PI3K/Akt/mTOR è spesso disregolata nel cancro, rendendo PI3K un obiettivo chiave per la terapia oncologica. Gli inibitori di PI3K sono strumenti critici per studiare la trasduzione del segnale, la biologia del cancro e lo sviluppo di terapie mirate. Presso CymitQuimica, offriamo una varietà di inibitori di PI3K per supportare la tua ricerca nella segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 235 prodotti per "PI3K".
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VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formula:C17H22N8OPurezza:97.82% - 99.54%Colore e forma:White SolidPeso molecolare:354.41ETP-46321
CAS:ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).Formula:C20H27N9O3SPurezza:99.8%Colore e forma:SolidPeso molecolare:473.55Ref: TM-TQ0229
1mg37,00€5mg82,00€1mL*10mM (DMSO)86,00€10mg116,00€25mg212,00€50mg298,00€100mg408,00€200mg552,00€Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFormula:C14H11ClN6O3Purezza:99.25% - 99.74%Colore e forma:SolidPeso molecolare:346.73Ref: TM-T4219
2mg39,00€5mg58,00€1mL*10mM (DMSO)66,00€10mg88,00€25mg160,00€50mg215,00€100mg334,00€200mg494,00€Taselisib
CAS:Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.Formula:C24H28N8O2Purezza:99.62% - 99.79%Colore e forma:SolidPeso molecolare:460.53Ref: TM-T1999
2mg43,00€5mg63,00€1mL*10mM (DMSO)63,00€10mg96,00€25mg148,00€50mg187,00€100mg333,00€200mg495,00€500mg797,00€IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Formula:C26H23FN8OPurezza:99.31%Colore e forma:SolidPeso molecolare:482.51Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Formula:C20H18O5Purezza:98.92%Colore e forma:SolidPeso molecolare:338.35Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).Formula:C21H25F3N6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:450.46Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purezza:96.66% - 99.93%Colore e forma:White SolidPeso molecolare:332.39BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purezza:95.74% - 99.78%Colore e forma:White SolidPeso molecolare:534.53Ref: TM-T6072L
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg147,00€25mg295,00€50mg485,00€100mg737,00€NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formula:C20H14F3N3SPurezza:99.87% - 99.9%Colore e forma:SolidPeso molecolare:385.41Ref: TM-T3556
2mg35,00€5mg51,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg133,00€50mg225,00€100mg323,00€200mg447,00€GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.44Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Formula:C21H24NNaO8SPurezza:98% - 99.37%Colore e forma:SolidPeso molecolare:473.47SKI V
CAS:SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),Formula:C15H10O4Purezza:98.78%Colore e forma:Yellow SolidPeso molecolare:254.24Ref: TM-T8461
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg281,00€25mg485,00€50mg708,00€100mg1.044,00€AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Formula:C14H8FNO4SPurezza:99.06% - 99.09%Colore e forma:Orange SolidPeso molecolare:305.28Ref: TM-T6208
1mg37,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg128,00€25mg205,00€50mg309,00€100mg447,00€500mg973,00€Alpelisib hydrochloride
CAS:Alpelisib hydrochloride (BYL-719 HCl) is a potent PI3Kα inhibitor (IC₅₀ = 5 nM) with selectivity and oral bioavailability. Cancer research.Formula:C19H23ClF3N5O2SPurezza:97.64%Colore e forma:Yellow SolidPeso molecolare:477.93Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Formula:C23H26N4O3Purezza:98.41% - 99.69%Colore e forma:SolidPeso molecolare:406.48Heterophyllin B
CAS:Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.Formula:C40H58N8O8Purezza:98.77% - 99.85%Colore e forma:White SolidPeso molecolare:778.94AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Formula:C21H16FN7Purezza:98.9% - 99.24%Colore e forma:Crystalline SolidPeso molecolare:385.4P7C3-A20
CAS:P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.Formula:C22H19Br2FN2OPurezza:96.83% - ≥98%Colore e forma:White SolidPeso molecolare:506.21Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurezza:98.21% - 99.69%Colore e forma:SolidPeso molecolare:270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€
