Reagenti sintetici

<p>Applications ent-Ticagrelor is the enantiomer of Ticagrelor (T437700); the first reversible oral P2Y12 receptor antagonist that provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 4,4’,(5’)-Di-(tert-butylcyclohexano)-18-crown-6 is a crown ether-based sorbent used in the analysis and separation of minerals.<br>References Yankovskaya, V. et al: J. Radioanal. Nucl. Chem., 314, 119 (2017);<br></p>

<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tricyclohexyl Phosphine is a ligand catalyst used primarily in organometallic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanford, M. et al.: J. Am. CHem. Soc., 123, 6543 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications A selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, D.T., et al.: Life Sci., 15, 471 (1974), Goldstein, D.J., et al.: Br. J. Psychiat., 166, 660 (1995), Ni, Y.G., et al.: Proc. Nat. Acad. Sci. USA, 94, 2036 (1997)<br></p>

<p>Applications Aluminum Bromide, is used as a catalyst for the Friedel-Crafts alkylation reaction, and also for bromination and isomerization in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Encyclopedia of Reagents for Organic Synthesis. (2001); Renfew, M. M., et al.: J. Chem. Educate. 68 (9, (1991);<br></p>

<p>Applications Aluminum isopropoxide is a compound used as an initiator for the polymerization of various compounds, such as lactides. Aluminum isopropoxide is also used as a reducing agent for the reduction of Cinnamaldehyde (C442020).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dubois, P., et al.: Macromolecules. 24, 2266 (1991); Hájek, J., et al.: Appl. Catal. A: Gen., 251, 385 (2003); Lou, X., et al.: Macromol. Rapid Comm., 23, 126 (2002)<br></p>

<p>Applications 1-(azidomethyl)-3-methoxybenzene (cas# 123767-44-2) is a useful research chemical.<br></p>

<p>Applications 5-Ethylpyridine-2-carboxylic Acid (cas# 770-08-1) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).<br>References Johnson, T. W., et al.: J. Med. Chem., 57, 4720 (2014);<br></p>

<p>Applications MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase.<br>References Wright, S., et. al.: Bioorg. Med. Chem. Lett., 13, 2055 (2003)<br></p>

<p>Applications 4-Hydroxy-3,5-dimethylbenzoic Acid is used in the synthesis of Mexiletine (M340800) derivatives as orally bioavailable inhibitors. Also, used as a chemical reagent in the preparation of potent transthyretin (TTR) amyloidogenesis inhibitors affecting thyroid hormone.<br>References Frederickson, M. et al.: J. Med. Chem., 51, 183 (2008); Johnson, S. et al.: J. Med. Chem., 51, 260 (2008);<br></p>

<p>Stability Volatile<br>Applications N-Ethylbutylamine is used as a reagent in the synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuppast, B., et al.: Eur. J. Med. Chem., 78, 1 (2014)<br></p>

<p>Stability Volatile<br>Applications rac 1,2-Diaminopropane is used as model precursor in the electron induced deposition of amorphous carbon nitride films. It is also used to synthesize cage peroxide, 1,6-diaza-3,4,8,9-tetraoxa-11-methylbicyclo[4.4.2]dodecane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wnuk, J., et al.: J. Phys. Chem., 113, 12345 (2009); Edward, J., et al.: Can. J. Chem., 77, 1057 (1999)<br></p>

<p>Applications 3,3-Dimethylacryloyl Chloride is a reactant in the synthesis of novel 4-substituted coumarin derivative, which exhibits significant antiproliferative activity toward tumor cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, Dong., et al.: J. Med. Chem., 59, 5721-5739 (2016)<br></p>

<p>Impurity Eletriptan Impurity 13<br>Applications Tris(2-methylphenyl)phosphine (Eletriptan Impurity 13) is a phosphine catalyst. It can be used in the rhodium-catalyzed hydrogenation, Suzuki-Miyaura cross-coupling reactions and Heck reactions.<br>References Hoen, R., et al.: Org. Biomol. Chem., 5, 267 (2007); Haug, B., et al.: Bioorg. Med. Chem. Lett., 17, 2361 (2007); Cacchi, S., et al.: Org. Biomol. Chem., 9, 1727 (2011)<br></p>

<p>Applications Chiral ligand for metal mediated asymmetric catalysis.<br>References Inui, Y., et al.: Chem. Pharm. Bull., 57, 1158 (2009), Lam, K., et al.: Eur. J. Med. Chem., 45, 5527 (2010),<br></p>

<p>Applications (S)​-​(-​)​-​1-​Phenyl-​1-​propanol is a building block used in the synthesis of inhibitors of steroid 11-β hydroxylation in the adrenal cortex related to androgen production in the fetus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zolle, I. et al.: J. med. Chem., 51, 2244 (2008);<br></p>

<p>Applications 3,5-Di-t-butyl-2-hydroxybenzaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-t-butyl-2-hydroxybenzaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).<br>References Tuerkkan, B. et al.: Trans. Met. Chem., 36, 679 (2011); Fusi, F. et al.: Biochem. Biopharmacol., 69, 485 (2005);<br></p>

<p>Applications (R)-(-)-3-Hydroxypyrrolidine is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.<br>References Sanchez, J. et al.: J. Med Chem., 35, 1764 (1992); Gao, J. et al.: Qilu Yao., 31, 68 (2012):<br></p>

<p>Applications Phenyl Chlorothionoformate is used in the preparation of an bicyclic thymidine analogs as selective inhibitors of Thymidine monophosphate kinase Mycobacterium tuberculosis (TMPKmt).<br>References Vanheusden, V. et al.: J. Med. Chem., 47, 6187 (2004);<br></p>

<p>Applications (1R,2S)-(-)-2-Amino-1,2-diphenylethanol is a hydroxylated 1,2-diphenethylamine derivative with affinity for the NMDA receptor.<br>References Berger, M.L. et al.: Bioorg. Med. Chem., 17, 3456 (2009);<br></p>

<p>Applications (S)-1,1-Diphenylprolinol is a useful catalyst for the preparation of flavonoids.<br>References Hu, J., et al.: Chem. Commun. (Cambridge, UK), 56, 10018 (2020)<br></p>

<p>Applications An intermediate of synergistic pesticide Boscalid. Also, used in the preparation of thieno[2.3-b]pyrrole derivatives as cannabinoid receptor agonists useful in mono- and combination therapy of diseases.<br>References Granger, D., et al.: Arthritis Rheum., 37, 1053 (1994), Robinson, R., et al.: J. Med. Chem., 39, 10 (1996),<br></p>

<p>Applications Nickel boride, (cas# 12007-01-1) is a useful research chemical.<br></p>

<p>Applications Silver benzoate is an aromatic salt that is used as a catalyst to prepare β-amino acids (such as N-Acetyl-β-alanine [A168070]) from α-amino acids (such as D-Alanine [A480995]). Silver benzoate is also used as a catalyst in Wolff rearrangement reactions.<br>References Barnes, R. &amp; Prochaska, R.: J. Am. Chem. Soc., 72, 3188 (1950); Ogilvie, W., et al.: Bioorg. Med. Chem., 7, 1521 (1999); Podlech, J. &amp; Seebach, D.: Lieb. Ann., 1995, 1217 (1995)<br></p>

<p>Applications 3-Amino-2-Naphthol (cas# 5417-63-0) is a useful research chemical.<br></p>

<p>Applications (-)-Corey Lactone Diol is an intermediate of Iloprost (I267300) and shows inhibitory activity towards β-lactamase. Iloprost (I267300) is a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia.<br>References Gal, Z. et al.: J. Chemother., 12, 274 (2000); Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007); Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008);<br></p>

<p>Applications Calcium Hypochlorite is a general chemical reagent used in the preparation of deicing salt. As well used as a disinfecting agent for pools as well as a disinfecting additive for dental stone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Farnam, Y. et al.: Cement Conc. Comp., 64, 1 (2015); Twomey, J. et al.: J. Prosthet. Dent., 90, 282 (2003);<br></p>

<p>Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.<br>References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)<br></p>

<p>Applications Intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Stability Very Hygroscopic<br>Applications Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).<br>References (1) Klamer, D., et al.: Eur. J. Pharmacol. (2004) 503: 103-107(2) Marletta, M.A.: J. Med. Chem., 37(13), 1899 (1994)(3) Zhang, H.Q., et al.: J. Med. Chem., 40, 3869 (1997)<br></p>

<p>Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.<br>References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);<br></p>

<p>Applications Niobium Pentachloride is a reagent used in the synthesis of mixed chloro-aryloxide compounds and dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ilin, A. et al.: J. Alloy. Comp., 748, 543 (2018); Yuan, L. et al.: Inorg. Chem., 57, 4226 (2018);<br></p>

<p>Applications WAY-100635 Maleate Salt is a selective SR-2B antagonist. It can be used in biological study of drug effects viewed from a signal transduction network perspective.<br>References Fliri, A., et al.: J Med Chem, 52, 8038 (2009)<br></p>

<p>Applications Magnesium tert-Butoxide is a reagent used in deprotonation reactions in organic synthesis. A mild alkaline earth metal alkoxide base that also functions as a Lewis acid and Bronsted base in chemical transformations.<br>References Ponikiewski, L., et al.: Z. Anorg. Allg. Chem., 634, 1770 (2008); Roman, D. S., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2013)<br></p>

<p>Applications Used in the preparation of antibacterial oxazolidinones.<br>References Kim, J. et al.: 19, 550 (2009); Michael R. et al.: J. Med. Chem., 50, 5886 (2007)<br></p>

<p>Applications Tetrabutylammonium tetrafluoroborate (cas# 429-42-5) is a useful research chemical.<br></p>

<p>Applications Tetrabutylammonium Hydroxide is used in biological studies for the detection of counter-anion effect on antimicrobial activity of tetrabutylammonium salts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ingalsbe, M.L., et al.: Bioorg. Med. Chem., 19, 4984 (2009)<br></p>

<p>Applications LY2157299 is a TGF-β type I receptor kinase inhibitor. LY2157299 has been used to inhance chemotherapy action against triple negative breast cancer (TNBC).<br>References Bhola, N.E., et. al.: J. Clin. Invest., 123, 1348 (2013)<br></p>

<p>Applications Protected Propargyl. A possible genotoxic compound that can affect the bacterial and mammalian cell systems.<br>References Glowienke, S. et al., Mutat. Res. Genet. Tox., 581, 23 (2005)<br></p>

<p>Applications 3,4-Difluoro-benzoic Acid is a useful synthetic intermediate. It is used to synthesize 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.<br>References Lim, C., et al.: Bioorgan. Med. Chem. Lett., 21, 2309 (2011);<br></p>

<p>Applications (4-Dimethylaminophenyl)di-tert-butylphosphine (cas# 932710-63-9) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications Galeterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor.<br>References Soifer, H.S., et al.: J. Biol. Chem., 287, 3777 (2012); Vasaitis, T., et al.: Molec. Cancer. Therap., 7, 2348 (2008);<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications.<br>References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003);<br></p>

<p>Applications SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.<br>References Mizuno, S. et al.: Am. J. Respir. Cell. Mol. Biol., 47, 679 (2012)); Yoshizawa, Y. et al.: Mol. Pharm., 9, 3486 (2012);<br></p>

<p>Applications Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest.<br>References Shibata, A. et al.: Mol Cell., 53, 7 (2014);<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Applications (2-Bromoethyl)trimethylammonium Bromide (cas# 2758-06-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Paetzel, M., et al.: J. Biol. Chem., 272, 9994 (1997), Francavilla, C., et al.: Bioorg. Med. Chem. Lett., 19, 2731 (2009),<br></p>

<p>Applications β-Naphthylcarbinol is an intermediate in the synthesis of 2-Naphthylcarbapenem derivatives with broad spectrum antibiotics with enhanced potency against MRSA.<br>References Martikainen, L.E., et al.: Euro. J. Pharma. Sci., 47, 996 (2012);<br></p>

<p>Applications 4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs.<br>References Gohil, V. et al.: Ind. J. Exp. Biol., 48, 265 (2010); Toth, B. et al.: J. Toxicol. Environ. Health, 8, 1 (1981);<br></p>

<p>Applications IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. IWP-2 is useful in the treatment diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.<br>References Poss, K., et al.: Dev. Biol., 222, 347 (2000), Tanaka, K., et al.: Eur. J. Biochem., 267, 4300 (2000), Clevers, H., et al.: Cell, 2006, 127, 469 (2006),<br></p>

<p>Applications Iodoethane, is used in a variety of organic chemical reactions including the synthesis if disubstituted α-amino acids through alkylation reaction. Also used in electrochemical reduction reactions in the preparation of carbamates.<br>References Feroci, M. et al.: J. Org. Chem., 72, 200 (2007); Xu, P. et al.: J. Org. Chem., 71, 4364 (2006);<br></p>

<p>Applications Tributylhexadecylphosphonium Bromide (CAS# 14937-45-2) is a dynamic compound used as a surface modifier for thermal properties of palygorskite, an additive in water to improve resistance of epoxy-anhydride matrices, and as a modifier of phenolic resin to improve thermal degradation.<br>References Cisneros-Rosado, D. E.; et al.: Polym. Compos., 39, E1531 (2018).; Capiel, G.; et al.: Polym. Adv. Technol., 28, 886 (2017); Asaro, L.; J. Therm. Anal. Calorim., 128, 1463 (2017).<br></p>