Modulatori enzimatici
I modulatori enzimatici sono composti che possono aumentare o inibire l'attività degli enzimi, regolando così la velocità delle reazioni biochimiche. Questi modulatori svolgono un ruolo cruciale nel controllo delle vie metaboliche, della segnalazione cellulare e di vari processi fisiologici. I modulatori enzimatici sono ampiamente utilizzati nella ricerca e nello sviluppo di farmaci per studiare le funzioni enzimatiche e sviluppare agenti terapeutici. Presso CymitQuimica, offriamo una gamma completa di modulatori enzimatici di alta qualità per supportare la vostra ricerca nella regolazione enzimatica e nella scoperta di farmaci.
Sottocategorie di "Modulatori enzimatici"
Trovati 693 prodotti di "Modulatori enzimatici"
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AZD 1208
CAS:Inhibits proto-oncogene Pim kinases (Pim-1, Pim-2 and Pim-3); antineoplasticFormula:C21H21N3O2SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:379.48 g/molODQ
CAS:Inhibitor of guanylyl cyclaseFormula:C9H5N3O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:187.16 g/molOmeprazole - Bio-X ™
CAS:Omeprazole is a proton pump inhibitor (PPI) that inhibits the production of gastric acid in the stomach. This is due to Omeprazole binding through a stable disulphide bond to the H+/K+ ATPase enzyme found on parietal cells, and preventing hydrogen ion transport. Consequently, gastric acid secretion is supressed. As a PPI, Omerprazole can be used to treat disorders where gastric acid is over-secreted. Examples of these disorders are gastroesophageal reflux disease (GERD) and peptic ulcer disease.Formula:C17H19N3O3SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:345.42 g/molALW-II-41-27
CAS:LW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor used for cancer treatment.Formula:C32H32F3N5O2SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:607.69 g/molGKT-137831
CAS:NADPH oxidase inhibitor; anti-inflammatory
Formula:C21H19ClN4O2Purezza:Min. 95%Colore e forma:Off-White PowderPeso molecolare:394.85 g/molA 66
CAS:Specific inhibitor of the phosphoinositide 3-kinase (PI3K) alpha subunit with IC50 of 32 nM. In heart muscle it negatively regulates hypertrophic growth, causes increase in late sodium current and leads to arrhythmias. In tumours it inhibits the p110α subunit of PI3K and blocks growth factor signalling resulting in reduced tumour growth.
Formula:C17H23N5O2S2Purezza:Min. 95%Colore e forma:SolidPeso molecolare:393.53 g/molOxyphenbutazone hydrate
CAS:Inhibitor of COX-1 and COX-2 cyclooxygenasesFormula:C19H20N2O3•H2OPurezza:Min. 95%Colore e forma:PowderPeso molecolare:342.39 g/molLapatinib base - Bio-X ™
CAS:Lapatinib is an antineoplastic agent used to treat breast and lung cancer. This drug is also a tyrosine kinase inhibitor and inhibits human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1). Lapatinib has shown to inhibit ERBB-driven tumor cell growth in vitro and in various animal models.Formula:C29H26ClFN4O4SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:581.06 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Formula:C13H11Cl2N5O4Purezza:Min. 95%Colore e forma:PowderPeso molecolare:372.16 g/molEntinostat
CAS:Inhibits histone deacetylase (HDAC)
Formula:C21H20N4O3Purezza:Min. 95%Colore e forma:Off-White PowderPeso molecolare:376.15354Chymostatin
CAS:Inhibitor of chymotrypsinFormula:C31H41N7O6Colore e forma:White To Yellowish SolidPeso molecolare:607.7 g/molPX 866
CAS:Potent and irreversible inhibitor of phosphoinositide-3-kinase (PtdIns-3-kinase) with IC50 of 0.1 nM. PX 866 inhibited cell motility and growth of 3D spheroids of glioblastoma, breast, prostate and colon cancer cell lines at low nanomolar concentrations. PX 866 also exhibited anti-tumoral activity in vivo in xenograft models for ovarian and lung cancer.Formula:C29H35NO8Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:525.59 g/molBAY 607550
CAS:A selective and potent inhibitor of phosphodiesterase 2 (PDE2). Raises cAMP and cGMP levels in neurons, improves social recognition and object memory in murine animals. Reverses anxiolytic effects induced by oxidative stress in mice by blocking cGMP-PKG signaling.
Formula:C27H32N4O4Purezza:Min. 95%Colore e forma:PowderPeso molecolare:476.24236MGCD 265
CAS:Inhibits MET, VEGFR1-3, Tie and Ron tyrosine kinases; antineoplasticFormula:C26H20FN5O2S2Purezza:Min. 95%Peso molecolare:517.60 g/molMK 886 - Bio-X ™
CAS:MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase.Formula:C27H34ClNO2SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:472.08 g/molSCH 772984
CAS:Inhibitor of ERK1 and ERK2 serine/threonine kinasesFormula:C33H33N9O2Purezza:Min. 95%Colore e forma:Light (Or Pale) Yellow To Yellow SolidPeso molecolare:587.67 g/molSB 431542
CAS:Inhibitor of activin receptor-like kinases (ALK4, ALK5 and ALK7), members of TGFβ type I receptor family. Blocks activin- and TGFβ-mediated signaling and phosphorylation of Smad2 downstream. Suppresses tumor-promoting and tumor-suppressing effects of TGFβ. Promotes differentiation of human embryonic stem cells (hESCs), whilst sustaining mouse ESCs in the undifferentiated state.Formula:C22H16N4O3Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:384.4 g/moleCF506
CAS:Selective inhibitor of the Src kinase family with subnanomolar IC50 values and good selectivity over c-Abl, PDGFRα and c-Kit kinases. The compound is effective in inhibiting growth in drug resistant cancer cell lines. In a recent study, it inhibited the growth of HER2-positive breast cancer cell lines which were resistant to pan-HER family kinase inhibitors such as lapatinib.Formula:C26H38N8O3Purezza:Min. 95%Colore e forma:SolidPeso molecolare:510.63 g/molBLU 667
CAS:RET receptor tyroine kinase inhibitorFormula:C27H32FN9O2Purezza:Min. 95%Colore e forma:White/Off-White SolidPeso molecolare:533.6 g/molRigosertib sodium
CAS:Rigosertib sodium is an experimental chemotherapeutic agent that is a derivative of benzyl styryl sulfone. It is synthesized chemically and functions primarily by inhibiting key signaling pathways involved in cancer cell proliferation. Specifically, Rigosertib targets the RAS signaling pathway along with the phosphatidylinositol-3-kinase/AKT and polo-like kinase 1 (Plk1) pathways, impeding the progression of the cell cycle and inducing apoptosis in malignant cells.Formula:C21H24NNaO8SPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:473.47 g/molAbemaciclib
CAS:Inhibitor of cyclin-dependent kinases CDK4 and CDK6Formula:C27H32F2N8Purezza:Min. 95%Peso molecolare:506.59 g/molGilteritinib
CAS:Inhibitor of FLT3 and AXL tyrosine kinasesFormula:C29H44N8O3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:552.71 g/molSulindac - Bio-X ™
CAS:Sulindac is a non-steroidal anti-inflammatory drug that has anti-inflammatory and analgesic properties. It is used to relieve the pain of osteoarthritis and rheumatoid arthritis by reducing inflammation and inhibiting the production of prostaglandins, which are chemicals that cause inflammation.Formula:C20H17FO3SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:356.41 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormula:C15H18N2OPurezza:(%) Min. 98%Colore e forma:PowderPeso molecolare:242.32 g/molLY 411575
CAS:Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Formula:C26H23F2N3O4Purezza:Min. 95%Colore e forma:SolidPeso molecolare:479.48 g/molMethocarbamol
CAS:Inhibitor of carbonic anhydrase; muscle relaxantFormula:C11H15NO5Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:241.24 g/molLovastatin - Bio-X ™
CAS:Lovastatin is an HMG-CoA reductase inhibitor that is used to lower LDL cholesterol levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.Formula:C24H36O5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:404.54 g/molFasudil hydrochloride
CAS:Fasudil hydrochloride is a Rho-kinase inhibitor, which is a synthetic compound derived from natural sources, primarily used in scientific research. The mode of action of Fasudil hydrochloride involves the inhibition of Rho-associated protein kinase (ROCK), a crucial player in the regulation of the actin cytoskeleton. By inhibiting ROCK, Fasudil alters various cellular functions, including contraction, motility, proliferation, and apoptosis.Formula:C14H17N3O2S•HClPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:327.83 g/molBetrixaban
CAS:Inhibitor of factor XaFormula:C23H22ClN5O3Purezza:Min. 95%Colore e forma:Off-White PowderPeso molecolare:451.91 g/molMRK 560
CAS:γ-secretase inhibitor; reduces amyloid-β in brainÂ
Formula:C19H17ClF5NO4S2Purezza:Min. 95%Peso molecolare:517.92 g/molLarotrectinib sulphate
CAS:A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.Formula:C21H22F2N6O2H2SO4Purezza:Min. 95%Peso molecolare:526.51 g/molTacrolimus
CAS:Antirheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormula:C44H69NO12Purezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:804.02 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formula:C20H20N4O2Purezza:Min. 95%Peso molecolare:348.4 g/mol5-Fluorouracil - Bio-X ™
CAS:5-Fluorouracil is a cytotoxic drug that inhibits the synthesis of DNA. It is used in combination therapy to treat cancer and is a pyrimidine analog. This drug inhibits the formation of thymidylate synthase from uracil. As a result, this leads to DNA and RNA synthesis inhibition and cell death.Formula:C4H3FN2O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:130.08 g/molGRL 0617
CAS:A novel non-covalent inhibitor of the PLpro protease from SARS-CoV-2 and SARS-CoV viruses. GRL 0617 inhibits the proteolytic processing of the viral polypeptide. As PLpro also acts as a protease in pathways involved in innate immunity, there are indications that it can promote immunity against the virus.Formula:C20H20N2OPurezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:304.39 g/molOdiparcil
CAS:Dipeptidyl peptidase 4 (DPP4) inhibitor
Formula:C15H16O6SPurezza:Min. 99%Colore e forma:PowderPeso molecolare:324.35 g/molIdelalisib
CAS:Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Formula:C22H18FN7OPurezza:Min. 95%Colore e forma:PowderPeso molecolare:415.42 g/molTemsirolimus
CAS:mTOR serine/threonine kinase inhibitorFormula:C56H87NO16Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,030.29 g/molBKM 120
CAS:Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Formula:C18H21O2N6F3Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:410.39 g/molN-Butyldeoxynojirimycin
CAS:Competitive inhibitor of ceramide-glycosyltransferase used for substrate reduction therapy in lysosomal storage disorders. It inhibits glucosylceramide synthase, which catalyses the initial step in glycosphingolipid biosynthetic pathway. This compound delays the onset of symptoms in type 1 Gaucher disease, Sandhoff disease and Tay-Sachs disease. It also reduces brain abnormalities in mucolipidosis type IV.Formula:C10H21NO4Purezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:219.28 g/molPKC 412
CAS:Inhibits multiple protein kinases, such as PKC and FLT3Formula:C35H30N4O4Purezza:Min. 95%Colore e forma:PowderPeso molecolare:570.64 g/molTivozanib
CAS:Inhibitor of VEGF receptorsFormula:C22H19ClN4O5Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:454.86 g/molPimasertib
CAS:A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formula:C15H15FIN3O3Purezza:Min. 95%Colore e forma:White To Yellow SolidPeso molecolare:431.2 g/molDabigatran etexilate - Bio-X ™
CAS:Dabigatran is an anticoagulant that is used for the treatment of atrial fibrillation and prevention of venous thromboembolic events. It is a drug that acts as an inhibitor of the enzyme thrombin. Dabigatran inhibits platelet activation and aggregation, which reduces the risk of stroke or other vascular events. Dabigatran is a prodrug and does not have any activity in its active form.
Formula:C34H41N7O5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:627.73 g/molTacrolimus monohydrate
CAS:Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormula:C44H69NO12·H2OPurezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:822.03 g/molJNJ 10198409
CAS:Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.Formula:C18H16FN3O2Purezza:Min. 95%Colore e forma:SolidPeso molecolare:325.34 g/molApatinib mesylate
CAS:Inhibitor of VEGFR; antineoplasticFormula:C24H23N5O·CH4O3SPurezza:Min. 95%Peso molecolare:493.58 g/molA 939572
CAS:Inhibitor of stearoyl-CoA desaturase SCD1 with IC50 of 6.3 nM, as measured in the SCD1-expressing human microsomes. A 939572 exhibited anticancer activity as it reduced cell proliferation and triggered cell killing in human non-small cell lung carcinoma cells. A 939572 inhibited tumour growth in an in vivo model for gastric carcinoma and reduced the oleic acid:stearic acid ratio in mouse liver and plasma.Formula:C20H22ClN3O3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:387.86 g/molKU-0063794
CAS:Inhibits mTORC1 and mTORC2 serine/threonine kinasesFormula:C25H31N5O4Purezza:Min. 95%Colore e forma:White To Beige To Yellow SolidPeso molecolare:465.54 g/molNiacinamide
CAS:Vitamin B3; antioxidant; favours cell repairFormula:C6H6N2OPurezza:98.5 To 101.5 Area-%Colore e forma:White PowderPeso molecolare:122.12 g/mol
