TBTU

CAS: 125700-67-6

Ref. 01-4013268

Product Information

• Name: TBTU
• Synonyms: O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium-tetrafluoroborate, (Benzotriazol-1-yloxy-dimethylamino-methylene)dimethylammonium tetrafluoroborate, 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-), 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1), 2-(1H-Benzotriazol-1-YL)-1,1,3,3-tetramethyluronium Tetrafluoroborate, 2-(1H-Benzotriazol-1-yl)-N,N,N′,N′-tetramethylammonium tetrafluoroborate, Benzotriazol-1-yl-tetramethyluroniumtetrafluoroborate, Knorr Reagent, N,N,N',N'-tetramethyl-O-(Benzotriazol-1-YL)uronium Tetrafluoroborate, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylidene]-N-methylmethanaminium Tetrafluoroborate, O-(1H-Benzotriazol-1-YL)-1,1,3,3-tetramethyl-uronium Tetrafluoroborate, O-(1H-Benzotriazol-1-YL)-N,N,N',N'-tetramethyluronium Tetrafluoroborate, O-(1H-Benzotriazole-1-YL) N,N,N',N'-tetramethyl uronium Tetrafluoroborate, O-(Benzotriazol-1-yl)-N,N,N',N'-tetra methyluronium Tetrafluoroborate, O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, O-(Benzotriazol-l-yl)-N,N,N,N,-tetramethyluronium Tetrafluoroborate, O-Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate, O-Benzotriazolyl tetramethylisouronium tetrafluoroborate, Tbtu

Description

TBTU is successfully used as coupling reagent in solid phase peptide synthesis. It acts as an excellent activating reagent causing low racemization during condensation of peptide segments. A study of the structure of TBTU in solid state as well as in solution by Abdelmoty et al. showed that the compound is a guanidinium N-oxide and not an uronium salt.

• Brand: Bachem

Chemical properties

• Molecular weight: 321.09
• Formula: C₁₁H₁₆BF₄N₅O
• Color/Form: White