Pyr-Arg-Thr-Lys-Arg-AMC

CAS: 155575-02-3

Ref. 01-4018149

Product Information

• Name: Pyr-Arg-Thr-Lys-Arg-AMC
• Brand: Bachem
• Description: The fluorogenic substrate pERTKR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 2·10⁴ M-¹s-¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Also cleaved by proprotein convertase 4. Pyr-RTKR-AMC is an excellent substrate for flavivirin.

Chemical properties

• Molecular weight: 827.94
• Formula: C₃₇H₅₇N₁₃O₉
• Purity: 96.6%
• Color/Form: White Powder