- Dec-RVKR-CMK, Furin Inhibitor I, Furin Convertase Inhibitor (Chloromethylketone)
Dec-RVKR-CMK binds to the catalytic site of furin and therefore acts as a potent inhibitor of cleavage and fusion activity of viral glycoproteins, as well as virus replication. Furthermore it was demonstrated that Dec-RVKR-CMK decreased the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Apart from furin, Dec-RVKR-CMK also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).
Technical inquiry about: 01-4026850 Decanoyl-Arg-Val-Lys-Arg-chloromethylketone
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