Product Information
- N(A)-fmoc-N(E)(4,4-dime.-2,6-dioxocyclo-hexylidene)et.-L-lys
- N-Fmoc-N'-[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)Ethyl]-D-Lysine
- Fmoc-D-Lys(Dde)-OH
- Fmoc-L-Lys(Dde)-OH
The Nε-protecting group Dde is orthogonal to both Fmoc and Boc which allows on-resin modification of lysine side chains during Fmoc/tBu-based SPPS. The applications of Dde side-chain protection include synthesis of branched or di-epitopic peptides, preparation of MAP core molecules and lipo-MAPS, the synthesis of cyclic peptides, TASP molecules, and templates for combinatorial chemistry and synthetic proteins. Dde can be cleaved by 2% hydrazine in DMF.
Chemical properties
Technical inquiry about: 01-4027144 Fmoc-Lys(Dde)-OH
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