Product Information
Name:Hepcidin-25 (human)
Synonyms:
- LEAP-1 (human)
Brand:Bachem
Description:Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans. Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux. Nemeth et al. demonstrated that the N-terminal part of the peptide hormone is essential for its activity. Former CAS-number 342790-21-0.
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Chemical properties
Molecular weight:2789.4
Formula:C113H170N34O31S9
Purity:95.0%
Color/Form:White Powder
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