(Lys²²)-Amyloid β-Protein (1-40)

CAS: 302905-01-7

Ref. 01-4049003

Product Information

• Name: (Lys²²)-Amyloid β-Protein (1-40)
• Synonyms: Amyloid β-Protein (1-40) Italian Mutation
• Brand: Bachem
• Description: The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.

Chemical properties

• Molecular weight: 4328.92
• Formula: C₁₉₅H₃₀₀N₅₄O₅₆S
• Purity: 91.3%
• Color/Form: White Lyophilisate