α-Synuclein (67-78) (human)

CAS: 2243206-99-5

Ref. 01-4107368

Product Information

• Name: α-Synuclein (67-78) (human)
• Brand: Bachem
• Description: The Parkinson’s disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.

Chemical properties

• Molecular weight: 1001.14
• Formula: C₄₃H₇₆N₁₂O₁₅
• Purity: 96.4%
• Color/Form: White Powder