4-(Chloromethyl)pyridine hydrochloride, 98%

CAS: 1822-51-1

Ref. 02-A12859

Product Information

• Name: 4-(Chloromethyl)pyridine hydrochloride, 98%
• Synonyms: hydrogen 4-(chloromethyl)pyridine chloride, 4-(Chloromethyl)Pyridine, 4-(Chloromethyl)Pyridine Hydrochloride (1:1), 4-(Chloromethyl)Pyridinium Chloride, 4-(Chloromethyl)pyridine hydrochloride, 4-Chloro Methyl-Pyridine Hydrochloride, 4-Chloromethylpyridine chlorhydrate, 4-Chloromethylpyridine hydrochloride, 4-Chloromethylpyridine hydrochloride salt, 4-Picolyl chloride HCl (65% in water), 4-Pyridylmethyl chloride hydrochloride, Pyridine, 4-(chloromethyl)-, hydrochloride, Pyridine, 4-(chloromethyl)-, hydrochloride (1:1), 4-Picolyl chloride hydrochloride

Description

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst™15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Brand: Alfa Aesar By Thermo Fisher Scientific

Chemical properties

• Molecular weight: 164.03
• Formula: C₆H₇Cl₂N
• Purity: 98%
• Color/Form: Powder, Pale cream to cream to yellow to pale brown
• InChI key: ZDHKVKPZQKYREU-UHFFFAOYSA-N