02-A18119 - 2-thiouracil | 141-90-2

2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.

2-Thiouracil

2-Thiouracil

Applications Reagent used in the preparation of Antithyroid agents. References Toropov, A., et al.: Eur. J. Med. Chem., 45, 3581 (2010), Daniels, C., et al>.: J. Bacteriol., 192, 2169 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),

2-Thiouracil is a photochemical that reacts with DNA by intermolecular hydrogen bonding, leading to DNA strand breakage. The reaction mechanism of 2-thiouracil has been elucidated through in vitro assays, which showed that the drug binds to the major groove of DNA duplexes and causes cleavage in the region containing two nitrogen atoms.

2-Thiouracil is a versatile building block and useful intermediate in organic synthesis. It is also used as a reagent in the preparation of various other compounds, such as thiourea, 2-aminoethanethiol, and sulfhydryl. 2-Thiouracil has been shown to have antibacterial properties against staphylococci and streptococci in vitro.

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