Bestatin

CAS: 58970-76-6

Ref. 02-J61106

Product Information

• Name: Bestatin
• Synonyms: bestatin, <span class="text-smallcaps">L</span>-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-, <span class="text-smallcaps">L</span>-Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-, Bestain, N-(3-amino-2-hydroxy-4-phenylbutanoyl)leucine, N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-<span class="text-smallcaps">L</span>-leucine, N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-D-leucine, N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]leucine, NSC 265489, Nk 421, L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-, N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine, L-Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-

Description

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Brand: Alfa Aesar By Thermo Fisher Scientific

Chemical properties

• Molecular weight: 308.38
• Formula: C₁₆H₂₄N₂O₄
• Color/Form: White to pale cream, Powder
• InChI key: VGGGPCQERPFHOB-MCIONIFRSA-N