Doxepin hydrochloride

CAS: 1229-29-4

Ref. 02-J62579

Product Information

• Name: Doxepin hydrochloride
• Synonyms: hydrogen doxepin chloride, (3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine hydrochloride, (3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine hydrochloride, 1-Propanamine, 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, hydrochloride (1:1), 1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride, 11-(3-Dimethylaminopropylidene)-6,11-Dihydro-Benz[B,E]Oxepin Hcl, 3-(6,11-Dihydrodibenz(B,E)Oxepin-11-Ylidene)Propyldimethylamine Hcl, 3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine hydrochloride (1:1), Adapin, Aponal, Curatin, Dibenz[b,e]oxepin, 1-propanamine deriv., Dibenz[b,e]oxepin-Δ¹¹⁽⁶^H^),γ-propylamine, N,N-dimethyl-, hydrochloride, Doxepin Hydrochloride, Doxepine hydrochloride, N,N-Dimethyldibenz[b,e]oxepin-Δ¹¹⁽⁶^H^),γ-propylamine hydrochloride, P 3693A, Quitaxon, Silenor, Sinequan, Sinequin
• CAS: 1229-29-4

Description

It is a highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range. Also binds to the H4 histamine receptor (pKi = 6.79). Used clinically to treat anxiety and depression. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Brand: Alfa Aesar By Thermo Fisher Scientific

Chemical properties

• Molecular weight: 315.84
• Formula: C₁₉H₂₂ClNO
• Color/Form: Solid
• InChI key: MHNSPTUQQIYJOT-SJDTYFKWSA-N