Diclofenac sodium salt

CAS: 15307-79-6

Ref. 02-J62609

Product Information

• Name: Diclofenac sodium salt
• Synonyms: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt, Sodium 2-(2,6-dichloroanilino)phenylacetate, Abitren, Allvoran, Assaren, Benfofen, Bolabomin, Cataflam, Daispas, Declophen, Dedolor, Deflamat, Delphimix, Diacron, Dichronic, Diclo-Phlogont, Diclo-Puren, Diclobene, Diclobenin, Dicloberl, Diclodyn, Dicloflex, Diclogesic, Diclokalium, Diclomol, Diclon, Diclord, Diclorep, Dicloreum, Diclotard, Difene, Dikloron, Diklovit, Dolaut, Dolobasan, Duravolten, Dyclo, Dyloject, Dynapar, Effekton, Evofenac, Feloran, Fortfen, Inflaban, Kriplex, Modifenac, Naclof, Naclofen, Natrium-[2-[(2,6-dichlorphenyl)amino]phenyl]acetat, Neriodin, Neurodiclovit, Neurofenac, Novapirina, Olfen, Orthofen, Orthophen, Panamor, Phlogin, Primofenac, Profenac, Prophenatin, Refen, Rhumalgan, Saffrac, Sorelmon, Tsudohmin, Valetan, Voldal, Voltaren, Voltarol, Voltral, Voveran, Xenid, sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate, 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid sodium salt, Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, monosodium salt, Acetic acid, [o-(2,6-dichloroanilino)phenyl]-, monosodium salt, {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid, Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, sodium salt (1:1), sodium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate, GP 45840, 2[(2,6-dichlorophenyl)amino]-benzeneacetic aci monosodium, N-(2,6-Dichlorophenyl)-o-aminophenylacetic acid sodium salt

Description

Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Brand: Alfa Aesar By Thermo Fisher Scientific

Chemical properties

• Molecular weight: 318.14
• Formula: C₁₄H₁₀Cl₂NNaO₂
• Color/Form: Powder, White