Product Information
- triethyl methanetricarboxylate
- 1,1,1-Triethyl methanetricarboxylate
- 2-Ethoxycarbonyl-malonic acid diethyl ester
- Diethyl (carboethoxy)malonate
- Diethyl (ethoxycarbonyl)malonate
- Diethyl 2-ethoxycarbonylmalonate
- Methanetricarboxylic acid triethyl ester~Tris(carboethoxy)methane
- Methanetricarboxylic acid, 1,1,1-triethyl ester
- Methanetricarboxylic acid, triethyl ester
- NSC 11006
- See more synonyms
- Tri(ethoxycarbonyl)methane
- Tricarbethoxymethane
- Tricarboethoxymethane
- Tris(ethoxycarbonyl)methane
- Triethyl methanetricarboxylate
Methanetricarboxylates have been used as blocked malonic esters, restricting reaction with alkyl halides to monoalkylation. The unwanted carboxyl group can be removed by treatment with Na alkoxide, LDA or BCl3. Provides a useful 2-carbon chain extension method that adds to Michael acceptors under phase-transfer conditions. Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Chemical properties
Technical inquiry about: 02-L08356 Triethyl methanetricarboxylate, 98%
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