10-090274 - s-3-6-chloro-pyrimidin-4-yloxy-pyrrolidine-1-carboxylic-acid-tert-butyl-ester | 1314355-18-4

<p>Pyrrolidine</p>

<p>Applications A heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, X. et al.: Mini-Rev. Med. Chem., 10, 794 (2010); Gragutan, I. et al.: Beil. J. Org. Chem., 7, 699 (2011);<br></p>

<p>Pyrrolidine is a hypoglycemic agent that has been shown to have antibacterial efficacy against some gram-positive bacteria. It inhibits bacterial growth by binding to the enzyme ribonucleotide reductase, which is required for DNA synthesis. Pyrrolidine also has an antimicrobial effect on human cells and is a substrate for the enzyme IDO1, which may be responsible for many of its biological effects. Pyrrolidine binds to methanol solvent and has been shown to inhibit the activity of endometrial cells by reducing glucose uptake. The reaction with methanol solvent also causes pyrrolidine molecules to change conformation, making them more susceptible to inhibition by IDO1.</p>