10-397024 - 3-fluoro-6-methylphenyl-2-thienylmethanol | 1248371-61-0

<p>Applications 2-​Thiophenemethanol is a heterocyclic building block used in pharmaceutical and organic synthesis. It is a component of the synthesis of styrylheterocycle analogs of reservatrol which act as apoptosis-inducing agents. Also used in the preparation of diverse 2-aminothiophenes displaying biologically active antiproliferative activity.<br>References Antonioletti, R. et al.: Curr. Org. Chem., 21, 939 (2017); Thomas, J. et al.: Org. Biomol. Chem., 15, 3892 (2017);<br></p>

Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis,

<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>

<p>3-Thiophenemethanol was used in the preparation of 3-substituted thiophene conducting copolymers which has potential applications in electrochromic displays.1 It was also used in the synthesis of 4-(thiophene-3-ylmethoxy)phthalonitrile This Thermo Scientific Chemicals brand product was originally pa</p>

3-(Hydroxymethyl)thiophene

{5-[1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl}methanol

2-(Hydroxymethyl)thiophene

<p>2-Thiophenemethanol is a colorless liquid that has a strong, disagreeable odor and is soluble in water. It can be prepared by the reaction of 2-methylpropanal with trifluoroacetic acid. This compound reacts with methapyrilene to form polymers, which have a cationic character. The chemical structure of the molecule was determined by a combination of experimental techniques such as proton nuclear magnetic resonance spectroscopy, infrared spectroscopy, and mass spectrometry. Hydrogen bonding plays an important role in the structure of 2-thiophenemethanol as it forms intermolecular hydrogen bonds with neighboring molecules. The chemical formula for this compound is CH3C6H4SO2H. Hydrochloric acid can be used to break down this compound into methylmercaptan and sulfur dioxide.</p>

a-Terthienylmethanol is a reactive oxygen species (ROS) that is generated in the human endometrium. ROS, such as a-terthienylmethanol, are produced by NADPH oxidase and can cause apoptosis in cancer cells. This molecule has shown to have anticancer activity against endometrial cancer cells. It also induces morphological changes such as cell shrinkage and nuclear condensation, which may be due to ROS production. a-Terthienylmethanol has shown to inhibit growth of endometrial cancer cells by inhibiting protein synthesis and DNA replication. The mechanism of this inhibition is not yet known but may be related to an interaction with the cell membrane or interference with transcription factors.