10-F478866 - benzaldehyde-sodium-bisulfite

Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is a disulfide derivative of famotidine. It has been used as an analytical reagent for the determination of impurities in famotidine and other related compounds. Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is soluble in methanol, ethanol and water, but not in acetone. The compound can be prepared by reacting 4-(dimethylamino)-1H-1,2,3-benzothiadiazole with 2-[(diaminomethylene)amino]-4-(N'-methoxycarbonylthio)benzaldehyde and then reductive amination with sodium bisulfite.