10-F740542 - 2-26-dimethoxy-4-methylphenoxyacetic-acid | 857555-80-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

4-Methylphenoxyacetic acid

4-Chloro-2-methylphenoxyacetic acid

m-Methylphenoxyacetic acid

4-Methylphenoxyacetic acid is a coumarin derivative that has been shown to accumulate in mammalian cells. It has been used as a substrate for conjugation with sulfur and selenium, yielding solubility data. Conjugates of 4-methylphenoxyacetic acid have been characterized by NMR spectra and chemical structure analysis, which revealed the presence of butyric acid residues. The tissue culture studies showed that the mutant strain was unable to grow in the presence of 4-methylphenoxyacetic acid.

2-Methylphenoxyacetic acid is a small-molecule drug that acts as an inhibitor of the protein kinase C (PKC) enzyme. It binds to the active site of PKC and prevents it from phosphorylating other proteins, which ultimately leads to cell death. The PKC enzyme is a potential drug target for cancer and cardiovascular disease because it plays a role in both pathologies. 2-Methylphenoxyacetic acid has been shown to inhibit PKC in vitro and in vivo, with the latter being demonstrated using mathematical modeling and molecular dynamics simulations. 2-Methylphenoxyacetic acid also inhibits annexin II, which is believed to be involved in signal transduction pathways that lead to tumor growth. 2-Methylphenoxyacetic acid has been shown to bind to the hydroxyl group of phospholipids and form hydrogen bonds with amino acids that are important for protein–protein interactions or intermolecular hydrogen bonds.