2B-AFR-LF-MA0250 - mnk1-mab-24c2
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Mnk1 rabbit pAb
MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],Mnk1 (phospho Thr255) rabbit pAb
MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],Mnk1 (phospho Thr385) rabbit pAb
MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],Mnk1 (phospho Thr250) rabbit pAb
MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],PROTAC MNK1 degrader-1
ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.Formula:C35H38N6O6SColor and Shape:SolidMolecular weight:670.78Mnk1 active human
CAS:Mnk1 is a protein that belongs to the family of MAP kinases. It is expressed in cardiac cells and may regulate transcription-polymerase chain reactions, translation, and virus-mediated gene expression. Mnk1 has been shown to interact with proteins involved in cancer and hepatitis. Mnk1 has also been shown to be a potential therapeutic target for meningioma and cancer.
Purity:Min. 95%MNK1 ligand 1
CAS:MNK1ligand 1 (Compound 5) is an MNK1 ligand used in the synthesis of PROTACMNK1 degrader-1.Formula:C15H17N3OSColor and Shape:SolidMolecular weight:287.38Anti-Phospho-MNK1 (Thr250) Polyclonal Antibody
Antibody Type: Rabbit Polyclonal
Application: IHC-P,IHC-Fr,IF
Reactivity: Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)Color and Shape:LiquidMolecular weight:Theoretical: 51 kDa.CGP 57380
CAS:CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-likeFormula:C11H9FN6Purity:98.49%Color and Shape:SolidMolecular weight:244.23MKNK1 Protein, Human, Recombinant (His)
Expression system: E. coli
Length: 1-465, Full Length
Activity: Not TestedPurity:85%Color and Shape:Lyophilized PowderMolecular weight:58.2 kDa (Predicted)Ref: TM-TMPH-04003
1mg2,136.00€5µg99.00€10µg171.00€20µg276.00€50µg387.00€100µg515.00€200µg794.00€500µg1,420.00€ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).
Formula:C25H20N4O2Purity:99.72% - 99.79%Color and Shape:SolidMolecular weight:408.45HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Color and Shape:Odour SolidNUCC-0200808
NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.Color and Shape:Odour SolidQL-X-138 HCl
QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.Formula:C25H20ClN5O2Purity:99.25%Color and Shape:SoildMolecular weight:457.91
