HBsAg antibody (Subtype ad/ay)
Ref. 3D-70-HG15_R
1mg
318.00€
Product Information
Name:HBsAg antibody (Subtype ad/ay)
Brand:Biosynth
Description:HBsAg antibody (Subtype ad/ay) was raised in goat using human hepatitis B surface antigen as the immunogen.
The term HBsAg collectively refers to the three particle forms: Dane, filamentous, and spherical of the Hepatitis B (HB) virus which are made up of small HBs proteins (SHBs), middle HBs proteins (MHBs), and large HBs proteins (LHBs). These HBsAg proteins envelop the viral nucleocapsid and bind to the viral core. The LHB has a pre-S1, pre-S2, and S domain, the MHB does not have this pre-S1 domain while SHBs only have the S domain. The S domain's ability to form disulfide cross-linked dimers allows Dane particles of the HBsAg to interact with sulfated proteoglycans on host cells, resulting in HB infection. Furthermore, residues 2-48 which make up a conserved N-terminal sequence on the pre-S1 domain, allow HBsAg to bind to the Na+-Taurocholate Co-transporter Polypeptide (NTCP) on hepatocytes.
This antibody has potential for use in research and diagnostic applications of HB infection, a necro-inflammatory liver disease that can cause liver cirrhosis and hepatocellular carcinoma.
The term HBsAg collectively refers to the three particle forms: Dane, filamentous, and spherical of the Hepatitis B (HB) virus which are made up of small HBs proteins (SHBs), middle HBs proteins (MHBs), and large HBs proteins (LHBs). These HBsAg proteins envelop the viral nucleocapsid and bind to the viral core. The LHB has a pre-S1, pre-S2, and S domain, the MHB does not have this pre-S1 domain while SHBs only have the S domain. The S domain's ability to form disulfide cross-linked dimers allows Dane particles of the HBsAg to interact with sulfated proteoglycans on host cells, resulting in HB infection. Furthermore, residues 2-48 which make up a conserved N-terminal sequence on the pre-S1 domain, allow HBsAg to bind to the Na+-Taurocholate Co-transporter Polypeptide (NTCP) on hepatocytes.
This antibody has potential for use in research and diagnostic applications of HB infection, a necro-inflammatory liver disease that can cause liver cirrhosis and hepatocellular carcinoma.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Purity:Min. 95%
Technical inquiry about: HBsAg antibody (Subtype ad/ay)
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