Akt antibody

Ref. 3D-70R-33433

Product Information

• Name: Akt antibody
• Brand: Biosynth
• Description: Akt, also known as Protein Kinase B (PKB), is a vital cellular signaling protein that governs key processes such as cell growth, survival, metabolism, and proliferation. It operates within the PI3K/Akt pathway, a major signaling route activated by growth factors and hormones like insulin to promote cell survival and growth. When activated, Akt is recruited to the cell membrane and phosphorylated by kinases, including PDK1, which fully activates it. Once active, Akt influences various downstream pathways to inhibit apoptosis, support cell growth via the mTOR pathway, and enhance glucose metabolism, which is crucial for insulin response.In diseases like cancer and diabetes, Akt’s role is particularly significant. Cancer frequently involves dysregulation of the Akt pathway, often through mutations in pathway components like PI3K, PTEN, or Akt itself, leading to increased cell survival, unchecked growth, and resistance to treatment. In diabetes, insulin resistance reduces Akt pathway activity, impairing glucose uptake and raising blood glucose levels. Because of these regulatory effects on cell growth and metabolism, the Akt pathway is a central target in therapeutic research for treating conditions where its influence is disrupted.