AKT antibody

Ref. 3D-70R-49352

Product Information

• Name: AKT antibody
• Brand: Biosynth
• Description: Akt, also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase that plays a vital role in cellular processes such as growth, survival, metabolism, and proliferation. As a central player in the PI3K/Akt/mTOR pathway, it integrates signals essential for cellular adaptation and function. Humans have three main Akt isoforms—Akt1, Akt2, and Akt3—each encoded by separate genes. Akt activation begins when external signals, such as growth factors or insulin, bind to cell surface receptors, activating phosphoinositide 3-kinase (PI3K). This leads to the production of PIP3 on the cell membrane, recruiting Akt and initiating two crucial phosphorylation steps at Thr308 and Ser473, after which Akt becomes fully activated and moves within the cell to phosphorylate its target proteins.Akt’s core functions include promoting cell survival by inhibiting apoptosis through phosphorylation of pro-apoptotic proteins like BAD and Caspase-9, and supporting cell growth and proliferation by activating mTOR, a key regulator of protein synthesis. It also plays a significant role in metabolic regulation, increasing glucose uptake and glycolysis through GLUT4 translocation and hexokinase activation, particularly in muscle and fat tissues. Additionally, Akt promotes angiogenesis by enhancing VEGF expression, which aids tissue repair, and supports cell migration, aiding wound healing but also facilitating cancer cell spread. Due to its extensive role in cell survival and growth, Akt is often hyperactivated in cancers, driving unchecked cell division and tumor progression, making it a target for cancer therapies. Its influence on glucose metabolism also connects Akt to insulin signaling, where pathway defects can impair glucose uptake, contributing to insulin resistance and type 2 diabetes.