Product Information
Name:Ascomycin
Synonyms:
- ChangchuanmycinImmunomycinFK 520
Brand:Biosynth
Description:Ascomycin is an immunosuppressant macrolide lactone, which is derived from the soil bacterium *Streptomyces hygroscopicus*. It functions primarily by inhibiting the T-cell activation pathway. The mechanism involves binding to the immunophilin FKBP-12, forming a complex that inhibits the calcium-dependent phosphatase, calcineurin. This inhibition prevents the dephosphorylation and subsequent translocation of nuclear factor of activated T cells (NFAT), which is crucial for the transcription of interleukin-2 and other cytokines. Consequently, this suppresses the activation and proliferation of T-cells, which are essential components of the adaptive immune response.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:792.01 g/mol
Formula:C43H69NO12
Purity:Min. 95%
Technical inquiry about: Ascomycin
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