Product Information
- 11-Dehydrocorticosteron
- 11-Dehydrocorticosterone
- 11-Oxo-11-deoxycorticosterone
- 11-Oxocorticosterone
- 17-(1-keto-2-Hydroxyethyl)-Δ<sup>4</sup>-androsten-3,11-dione
- 21-Hydroxypregn-4-Ene-3,11,20-Trione
- 4-Pregnen-21-ol-3,11,20-trione
- Corticosterone, 11-dehydro-
- Dehydrocorticosterone
- Kendall's compound A
- See more synonyms
- Nsc-9702
- Pregn-4-ene-3,11,20-trione, 21-hydroxy-
- Δ<sup>4</sup>-Pregnen-21-ol-3,11,20-trione
- Δ<sup>4</sup>-Pregnene-21-ol-3,11,20-trione
11-Dehydrocorticosterone-13C3 is a synthetic glucocorticoid that is used as a nasal drug. It has been shown to inhibit the production of inflammatory cytokines, such as tumor necrosis factor and interleukin-1β, which are involved in the pathogenesis of autoimmune diseases. 11-Dehydrocorticosterone-13C3 binds to the glucocorticoid receptor with high affinity and specificity and possesses a hydroxyl group at C3 position. It is effective in inhibiting the production of proinflammatory cytokines in 3T3-L1 preadipocytes by blocking the function of nuclear factor kappa B (NFκB). It also inhibits the release of colony stimulating factors, such as granulocyte macrophage colony stimulating factor (GMCSF) and granulocyte colony stimulating factor (GCSF), from 3t3-l1 preadipocytes.
Chemical properties
Technical inquiry about: 3D-AAA07223 11-Dehydrocorticosterone-13C3
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