Aspirin Impurity D

Ref. 3D-AAA53075

Product Information

• Name: Aspirin Impurity D
• Brand: Biosynth
• Description: Aspirin Impurity D is an impurity that occurs in the synthesis of aspirin. It is a by-product of the acid catalyzed esterification reaction between acetylsalicylic acid and acetic anhydride. This impurity is characterized by its solubility in organic solvents, high UV absorption at 230 nm, and chemical stability to acids. Aspirin Impurity D has been shown to cause autoimmune diseases in rats and cancer in mice when injected intraperitoneally with a dose of 0.5 mg/kg. The target tissue for this impurity is unknown, but it may be due to its lipophilic nature. Aspirin Impurity D can be detected by chromatography with a column of silica gel or alumina as stationary phase and a mobile phase consisting of methanol/chloroform/water (4:4:6).

Chemical properties

• Molecular weight: 300.26 g/mol
• Formula: C₁₆H₁₂O₆
• Purity: Min. 95%