N-(Naphthalen-2-yl)acetamide

CAS: 581-97-5

Ref. 3D-AAA58197

Product Information

• Name: N-(Naphthalen-2-yl)acetamide
• Synonyms: 2-(Naphthalen-2-Yl)Acetamide, 2-Acetamidonaphthalene, 2-Acetylaminonaphthalene, Acetamide, N-2-naphthalenyl-, Acetamide, N-2-naphthalenyl- (9CI), Acetamide, N-2-naphthyl-, Ai3-16908, Brn 2208926, N-(2-Naphthyl)acetamide, N-(naphthalen-2-yl)acetamide, N-2-Naphthalenylacetamide, N-Acetoxy-2-naphthylamine, N-Acetyl-2-naphthylamine, N-Acetyl-beta-naphthylamine, N-Acetyl-β-naphthylamine, Nsc 3104, beta-Acetamidonaphthalide, β-Acetonaphthalide

Description

N-(Naphthalen-2-yl)acetamide is a synthetic compound that has been shown to have anti-cancer and anti-inflammatory properties. It is a prodrug of N-(naphthalen-2-yl)acetamide, the active form. The prodrug is hydrolyzed in vivo to the active form by the action of hydrochloric acid in mammalian cells. The prodrug also binds to amines and oligodeoxynucleotides and inhibits their synthesis. In addition, it inhibits calcium pantothenate, which is an essential cofactor for DNA synthesis. N-(Naphthalen-2-yl)acetamide also has been shown to inhibit tumor growth in animal models by blocking DNA synthesis and cell proliferation. The drug is metabolized into chloride ions that are toxic to cancer cells but not normal cells. The optimum pH for this reaction is 7.5.

• Brand: Biosynth

Chemical properties

• Molecular weight: 185.22 g/mol
• Formula: C₁₂H₁₁NO
• Purity: Min. 95%