2-Chloro-1-(4-chlorophenyl)ethanone

CAS: 937-20-2

Ref. 3D-AAA93720

Product Information

• Name: 2-Chloro-1-(4-chlorophenyl)ethanone
• Brand: Biosynth
• Description: 2-Chloro-1-(4-chlorophenyl)ethanone is a pyrazole derivative that inhibits the production of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), and IL-6. It also exhibits significant anti-inflammatory activity. 2-Chloro-1-(4-chlorophenyl)ethanone is synthesized from the Grignard reagent and chloroacetaldehyde. The synthesis proceeds in two steps: first, the Grignard reagent is added to chloroacetaldehyde in DMF at -78°C to form an organometallic intermediate; second, the organometallic intermediate reacts with an acid chloride to produce the desired product. This reaction can be catalyzed by aluminium chloride or zinc chloride. 2CPAE has a high solubility in organic solvents and surfactants such as sodium dodecyl

Chemical properties

• Molecular weight: 189.04 g/mol
• Formula: C₈H₆Cl₂O
• Purity: Min. 95%