Tapentadol-²-D-glucuronide solution

CAS: 1300037-86-8

Ref. 3D-ACC03786

Product Information

• Name: Tapentadol-²-D-glucuronide solution
• Brand: Biosynth
• Description: Tapentadol is a centrally acting analgesic agent that binds to the µ-opioid receptor. Tapentadol is metabolized in the liver by glucuronidation and sulfation. Tapentadol 2-D-glucuronide is an active metabolite of tapentadol and exhibits a higher affinity for µ-opioid receptors than tapentadol. The clinical relevance of this metabolite has not been studied, but concentrations of tapentadol 2-D-glucuronide in plasma may be useful for monitoring therapeutic effects and for assessing side effects such as respiratory depression. It is believed that tapentadol 2-D-glucuronide binds to opioid receptors in the brain, spinal cord, and peripheral nervous system, which accounts for its analgesic properties. The clinical development of tapentadol was designed to assess its safety and efficacy in pediatric patients (ages 6–17 years). Plasma concentrations were measured using liquid chromatography

Chemical properties

• Molecular weight: 397.46 g/mol
• Formula: C₂₀H₃₁NO₇
• Purity: Min. 95%